InAADR

Drug Information

Drug Name: Atovaquone (95233-18-4)
PubChem ID: 74989
SMILES: C1CC(CCC1C2=CC=C(C=C2)Cl)C3=C(C4=CC=CC=C4C(=O)C3=O)O
InchiKey: BSJMWHQBCZFXBR-UHFFFAOYSA-N
Therapeutic Category: Anti-Infective Agents, Antimalarials, Antiparasitic Agents, Antiprotozoal Agents, Enzyme Inhibitors

Computed Drug Properties

Molecular Weight (dalton): 366.844
LogP: 5.3485
Ring Count: 2
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 54.37

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Etoposide (33419-42-0) Acute Myeloid Leukaemia Synergistic Unclear The effect of atovaquone on etoposide pharmacokinetics in children with acute lymphoblastic leukemia

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Discomfort MetaADEDB
Abdominal Mass MetaADEDB
Abdominal Pain ADReCS
Abdominal Pain MetaADEDB
Abnormal Laboratory Findings MetaADEDB
Abnormal Lfts MetaADEDB
Acid Reflux MetaADEDB
Acquired Immune Deficiency Syndrome MetaADEDB
Acquired Night Blindness MetaADEDB
Activated Partial Thromboplastin Time Prolonged MetaADEDB
Acute Graft Versus Host Disease MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Myeloid Leukaemia Recurrent MetaADEDB
Acute Myocardial Infarction MetaADEDB
Acute Pancreatitis MetaADEDB
Acute Respiratory Failure MetaADEDB
Addison Disease MetaADEDB
Adenocarcinoma MetaADEDB
Adrenal Insufficiency MetaADEDB
Adrenal Neoplasm MetaADEDB
Aids-Related Opportunistic Infections MetaADEDB
Alanine Aminotransferase Increased ADReCS
Allergic Dermatitis MetaADEDB
Allergic Reaction ADReCS
Allergies MetaADEDB
Altered State Of Consciousness MetaADEDB
Alveolitis MetaADEDB
Amnesia MetaADEDB
Amylase Increased SIDER
Anaemia ADReCS
Anal Atresia MetaADEDB
Anger MetaADEDB
Angiitis MetaADEDB
Angioedema ADReCS
Anhidrosis MetaADEDB
Anion Gap Increased MetaADEDB
Anorectal Disorder MetaADEDB
Anorexia ADReCS
Anti-Hbc Igg Antibody Positive MetaADEDB
Anxiety ADReCS
Appendectomy MetaADEDB
Appendicitis MetaADEDB
Aptyalism MetaADEDB
Arteriosclerosis Coronary Artery MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Aspartate Aminotransferase Increased ADReCS
Aspiration Pleural Cavity MetaADEDB
Asthenia ADReCS
Asthma MetaADEDB
Atelectasis MetaADEDB
Atrial Tachycardia MetaADEDB
Atrophy MetaADEDB
Autoimmune Disorder MetaADEDB
Babesiosis MetaADEDB
Bacteraemia MetaADEDB
Bacterial Toxaemia MetaADEDB
Biliary Fibrosis MetaADEDB
Bilirubin Conjugated Increased MetaADEDB
Bk Virus Infection MetaADEDB
Blast Cell Crisis MetaADEDB
Blepharoptosis MetaADEDB
Blood Albumin Decreased MetaADEDB
Blood Alkaline Phosphatase Increased ADReCS
Blood Amylase Increased ADReCS
Blood Bilirubin Increased MetaADEDB
Blood Count Abnormal MetaADEDB
Blood Creatinine Increased ADReCS
Blood Culture Positive MetaADEDB
Blood Electrolytes Abnormal MetaADEDB
Blood Parathyroid Hormone Increased MetaADEDB
Blood Phosphorus Increased MetaADEDB
Blood Sodium MetaADEDB
Body Temperature Increased ADReCS
Bone Debridement MetaADEDB
Bone Disorder MetaADEDB
Bone Erosion MetaADEDB
Bone Fragmentation MetaADEDB
Bone Inflammation MetaADEDB
Bone Marrow Failure MetaADEDB
Bone Operation MetaADEDB
Bone Pain MetaADEDB
Bone Spur MetaADEDB
Brain Abscess MetaADEDB
Brain Oedema MetaADEDB
Bronchoalveolar Lavage MetaADEDB
Bronchopneumonia MetaADEDB
Bronchospasm ADReCS
Bulging MetaADEDB
Bundle Branch Block Right MetaADEDB
Burning Sensation Mucosal MetaADEDB
Bursitis MetaADEDB
Calculus Urinary MetaADEDB
Candidiasis Of Mouth MetaADEDB
Cardiac Decompensation MetaADEDB
Catheterisation Cardiac MetaADEDB
Cellulitis MetaADEDB
Central Line Infection MetaADEDB
Cerebral Toxoplasmosis MetaADEDB
Cervicalgia MetaADEDB
Chapped Lips MetaADEDB
Chest Tube Insertion MetaADEDB
Chill MetaADEDB
Cholangiolitis MetaADEDB
Chromatopsia MetaADEDB
Chronic Hepatic Failure MetaADEDB
Chronic Kidney Disease MetaADEDB
Chronic Ulcerative Colitis MetaADEDB
Circumstance Or Information Capable Of Leading To Medication Error MetaADEDB
Cmv Infection MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Constipation ADReCS
Convulsions Grand Mal MetaADEDB
Coombs Direct Test Positive MetaADEDB
Cor Pulmonale Acute MetaADEDB
Cor Pulmonale Chronic MetaADEDB
Cough ADReCS
Cough Increased ADReCS
Coughing Blood MetaADEDB
Creatinine Increased SIDER
Creatinine Renal Clearance Decreased MetaADEDB
Crest Syndrome MetaADEDB
Cryptococcosis MetaADEDB
Culture Positive MetaADEDB
Culture Stool Positive MetaADEDB
Cytolytic Hepatitis MetaADEDB
Cytomegalovirus Chorioretinitis MetaADEDB
Decreased Appetite ADReCS
Deep Vein Thromboses MetaADEDB
Deglutition Disorder MetaADEDB
Delusion MetaADEDB
Dental Abscess MetaADEDB
Dental Caries MetaADEDB
Dental Operation MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Device Failure MetaADEDB
Diabetes MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Dislocation MetaADEDB
Disorder Lung MetaADEDB
Disorder Renal MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Disseminated Lupus Erythematosus MetaADEDB
Diverticulum MetaADEDB
Dizziness ADReCS
Drug Hypersensitivity MetaADEDB
Dysgeusia ADReCS
Dyspepsia ADReCS
Dyspnoea ADReCS
Ear Ache MetaADEDB
Eating Disorder MetaADEDB
Echocardiogram Abnormal MetaADEDB
Edema Extremities MetaADEDB
Elevated Triglycerides MetaADEDB
Emesis MetaADEDB
Empyema MetaADEDB
Encephalitis MetaADEDB
End Stage Aids MetaADEDB
Endodontic Procedure MetaADEDB
Energy Increased MetaADEDB
Enlarged Spleen MetaADEDB
Enteritis MetaADEDB
Enterococcal Infection MetaADEDB
Eosinophil Count Increased MetaADEDB
Epistaxis MetaADEDB
Eruption MetaADEDB
Erysipelas MetaADEDB
Erythema ADReCS
Erythema Migrans MetaADEDB
Erythema Multiforme ADReCS
Escherichia Infection MetaADEDB
Essential Thrombocythaemia MetaADEDB
Euphoric Mood MetaADEDB
Excessive Salivation MetaADEDB
Excoriation MetaADEDB
External Ear Infection MetaADEDB
Eye Disorder SIDER
Eye Laser Surgery MetaADEDB
Facial Neuralgia MetaADEDB
Fallot Tetralogy MetaADEDB
Fatigue MetaADEDB
Febrile Neutropenia MetaADEDB
Feeding Tube Insertion MetaADEDB
Feeling Cold MetaADEDB
Fibroids MetaADEDB
Flank Pain MetaADEDB
Flu MetaADEDB
Fluid Overload MetaADEDB
Foot Deformity MetaADEDB
Foot Fracture MetaADEDB
Fractured Pelvis Nos MetaADEDB
Gastroduodenitis MetaADEDB
Gastroenteritis Viral MetaADEDB
Gastrointestinal Disorder SIDER
Gastrointestinal Pain ADReCS
Geotrichum Infection MetaADEDB
Gingival Infection MetaADEDB
Gingival Pain MetaADEDB
Graft Versus Host Disease MetaADEDB
Granulocytosis MetaADEDB
Granuloma MetaADEDB
Haemangioma MetaADEDB
Haemangioma Of Liver MetaADEDB
Haemochromatosis MetaADEDB
Haemoglobinuria MetaADEDB
Haemolytic Anaemia MetaADEDB
Haemophilus Sepsis MetaADEDB
Haemorrhage Intracranial MetaADEDB
Haemorrhage Rectum MetaADEDB
Haemorrhagic Hepatic Cyst MetaADEDB
Haemosiderosis MetaADEDB
Headache ADReCS
Heart Rate Increased MetaADEDB
Henoch-Schonlein Purpura MetaADEDB
Hepatic Atrophy MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Enzyme Abnormal MetaADEDB
Hepatic Failure ADReCS
Hepatitis ADReCS
Hepatitis B Surface Antigen Positive MetaADEDB
Hepatobiliary Disease SIDER
Hepatotoxicity MetaADEDB
Herpes Zoster Ophthalmic MetaADEDB
High Blood Pressure MetaADEDB
Hiv Disease MetaADEDB
Hiv Infection ADReCS
Hiv Wasting Syndrome MetaADEDB
Hospice Care MetaADEDB
Humerus Fracture MetaADEDB
Hydronephrosis MetaADEDB
Hydroureter MetaADEDB
Hyperglycaemia ADReCS
Hyperhidrosis ADReCS
Hyperkalaemia ADReCS
Hyperlipaemia MetaADEDB
Hypermagnesaemia MetaADEDB
Hypersensitivity ADReCS
Hypoaesthesia MetaADEDB
Hypoaesthesia Oral MetaADEDB
Hypoalbuminaemia MetaADEDB
Hypogammaglobulinaemia MetaADEDB
Hypoglycaemia ADReCS
Hypokalaemia MetaADEDB
Hypomagnesaemia MetaADEDB
Hypomania MetaADEDB
Hyponatraemia ADReCS
Hypophagia MetaADEDB
Hypophosphataemia MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Immune Reconstitution Syndrome MetaADEDB
Immune System Disorder SIDER
Impingement Syndrome MetaADEDB
Impulse-Control Disorder MetaADEDB
Inappropriate Affect MetaADEDB
Incoherent MetaADEDB
Increased Platelet Count MetaADEDB
Infection ADReCS
Influenza ADReCS
Injection Site Dermatitis MetaADEDB
Insomnia ADReCS
Intention Tremor MetaADEDB
Intravascular Haemolysis MetaADEDB
Keratopathy ADReCS
Kidney Failure MetaADEDB
Kidney Infection MetaADEDB
Laboratory Test Abnormal ADReCS
Laryngeal Disorder MetaADEDB
Lethargy MetaADEDB
Leukopenia Neonatal MetaADEDB
Lip Pain MetaADEDB
Lipase MetaADEDB
Loss Of Weight MetaADEDB
Lumbar Spinal Stenosis MetaADEDB
Lung Infection Pseudomonal MetaADEDB
Lyme Disease MetaADEDB
Lymphocytes Decreased MetaADEDB
Malaria MetaADEDB
Malocclusion MetaADEDB
Mental Status Changes MetaADEDB
Metastases To Spine MetaADEDB
Metastatic Neoplasm MetaADEDB
Methaemoglobinaemia ADReCS
Milia MetaADEDB
Mixed Connective Tissue Disease MetaADEDB
Mouth Ulcer MetaADEDB
Movement Disorder MetaADEDB
Musculoskeletal Discomfort ADReCS
Myalgia ADReCS
Mycobacterium Avium Complex Infection MetaADEDB
Nasal Congestion MetaADEDB
Nausea ADReCS
Nephrectomy MetaADEDB
Nephropathy Toxic MetaADEDB
Nervous Tension MetaADEDB
Neumonia MetaADEDB
Neuropathy Peripheral MetaADEDB
Neutropenia ADReCS
Non-Hodgkin Lymphoma MetaADEDB
Oculogyration MetaADEDB
Oliguria MetaADEDB
Oral Candidiasis ADReCS
Osteitis Deformans MetaADEDB
Osteoarthritis MetaADEDB
Osteolysis MetaADEDB
Osteomyelitis MetaADEDB
Osteopenia MetaADEDB
Osteoporosis MetaADEDB
Pachymeningitis MetaADEDB
Pain ADReCS
Palpitation MetaADEDB
Pancreatitis ADReCS
Pathogen Resistance MetaADEDB
Pedal Pulse Absent MetaADEDB
Pelvic Floor Muscle Weakness MetaADEDB
Periodontal Disease MetaADEDB
Periodontitis MetaADEDB
Pharmaceutical Product Complaint MetaADEDB
Phlebitis MetaADEDB
Phosphatase Alkaline Increased SIDER
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pneumococcal Sepsis MetaADEDB
Pneumocystis Infections MetaADEDB
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia Cytomegaloviral MetaADEDB
Pneumonia Fungal MetaADEDB
Pneumonia Pneumocystis MetaADEDB
Pneumothorax MetaADEDB
Polymyositis MetaADEDB
Poor Dental Condition MetaADEDB
Portal Hypertension MetaADEDB
Primary Effusion Lymphoma MetaADEDB
Proctitis Herpes MetaADEDB
Product Quality Issue MetaADEDB
Protein Total Increased MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Pruritus ADReCS
Pulmonary Alveolar Haemorrhage MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Mass MetaADEDB
Pulpitis Dental MetaADEDB
Pyelonephritis MetaADEDB
Pyrexia ADReCS
Rales MetaADEDB
Rash ADReCS
Rash Generalised MetaADEDB
Renal Atrophy MetaADEDB
Renal Impairment ADReCS
Renal Tubular Necrosis MetaADEDB
Respiratory Failure MetaADEDB
Retrograde Portal Vein Flow MetaADEDB
Rhabdomyolysis MetaADEDB
Rhinitis ADReCS
Sacroiliitis MetaADEDB
Scab MetaADEDB
Scan Bone Marrow Abnormal MetaADEDB
Schizophrenia MetaADEDB
Scleroderma MetaADEDB
Sensory Loss MetaADEDB
Sepsis Syndrome MetaADEDB
Sinusitis ADReCS
Sjogren Syndrome MetaADEDB
Skin Exfoliation ADReCS
Spinal Osteoarthritis MetaADEDB
Staphylococcal Bacteraemia MetaADEDB
Stevens-Johnson Syndrome ADReCS
Stress Fracture MetaADEDB
Sweating SIDER
T-Cell Lymphoma MetaADEDB
Throat Tightness ADReCS
Thrombocytopenia ADReCS
Thrombophlebitis MetaADEDB
Thrombotic Microangiopathy MetaADEDB
Tongue Disorder MetaADEDB
Tooth Disease MetaADEDB
Tooth Extraction MetaADEDB
Tooth Injury MetaADEDB
Toxoplasmosis MetaADEDB
Tracheobronchitis MetaADEDB
Transient Ischaemic Attack MetaADEDB
Tympanic Membrane Disorder MetaADEDB
Urethral Dilatation MetaADEDB
Urethral Disorder SIDER
Urinary Tract Disorder SIDER
Urosepsis MetaADEDB
Urticaria ADReCS
Uterine Enlargement MetaADEDB
Vaginal Disorder MetaADEDB
Venoocclusive Disease MetaADEDB
Venoocclusive Liver Disease MetaADEDB
Venous Thrombosis Limb MetaADEDB
Viral Haemorrhagic Cystitis MetaADEDB
Vitreous Detachment MetaADEDB
Vocal Cord Disorder MetaADEDB
Vomiting ADReCS
Wound Infection Staphylococcal MetaADEDB
X-Ray Limb MetaADEDB
Xanthopsia MetaADEDB

InAADR: Drug-Protein-ADRs database