| Drug Name: | Lisinopril (83915-83-7) |
|---|---|
| PubChem ID: | 22887897 |
| SMILES: | C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O.O |
| InchiKey: | BAVDEDVBIHTHJQ-UVJOBNTFSA-N |
| Therapeutic Category: | Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Cardiotonic Agents, Cardiovascular Agents, Enzyme Inhibitors, Protease Inhibitors, Protective Agents |
| Molecular Weight (dalton) | : | 423.51 |
| LogP | : | 0.4105 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 4 |
| Total Polar Surface Area | : | 164.46 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Pergolide (66104-22-1) | Hypotension | Antagonistic | All dopamine agonists causes hypotensive reactions during the first few days of treatment | Pergolide-induced hypotension |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Bradycardia | Angiotensin-converting enzyme precursor (P12821) | Renoprotective effects@ blood-pressure reduction@ reduction in left ventricular mass@ endothelial function [ ADR Type 1 ] | Angiotensin-converting enzyme (ACE) inhibition in type 2, diabetic patients-- interaction with ACE insertion/deletion polymorphism Kidney |
| Cough | B2 bradykinin receptor (P30411) | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough [ ADR Type 2 ] | Bradykinin B(2) receptor gene polymorphism is associated with angiotensin-converting enzyme inhibitor-related cough |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|---|---|
| garlic | Hypotension | Stockley’s drug interactions 8th edition; Stockley’s drug interactions 2008 pocket companion |
| Lo salt (a salt substitute containing 34.6 g potassium in every 100 g) | Arrhythmia | Stockley’s drug interactions 8th edition; Stockley’s drug interactions 2008 pocket companion |
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category