| Drug Name: | Azithromycin (83905-01-5) |
|---|---|
| PubChem ID: | 44317861 |
| SMILES: | CC[C@@H]1[C@@]([C@@H]([C@H](N(C[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)OC3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O |
| InchiKey: | MQTOSJVFKKJCRP-ZFJKUGCZSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 748.996 |
| LogP | : | 1.9007 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 14 |
| Hydrogen Bond Donor Count | : | 5 |
| Total Polar Surface Area | : | 180.08 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Disopyramide ((3737-09-5)) | Ventricular Fibrillation | Additive | Not fully established. An in vitro study using human liver microsomes indicated that azithromycin inhibits the metabolism (mono-N-dealkylation) of disopyramide which, in vivo, would be expected to reduce its loss from the body and increase its serum levels | Potentially fatal interaction between azithromycin and disopyramide |
| Rifabutin (72559-06-9) | Neutropenia | Additive | Rifabutin is enzyme inducers, which can increase the metabolism of other drugs by the liver, thereby reducing their serum levels.Rifabutin is also a substrate for cytochrome P450 isoenzyme CYP3A4. It has been suggested that lower body weight and concurrent clarithromycin may result in toxic rifabutin serum levels | Comparison of azithromycin and clarithromycin in their interactions with rifabutin in healthy volunteers |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category