| Drug Name: | Leuprolide acetate (74381-53-6) |
|---|---|
| PubChem ID: | 657181 |
| SMILES: | CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC2=CC=C(C=C2)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC3=CNC4=CC=CC=C43)NC(=O)[C@H](CC5=CN=CN5)NC(=O)[C@@H]6CCC(=O)N6 |
| InchiKey: | GFIJNRVAKGFPGQ-LIJARHBVSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 1209.42 |
| LogP | : | -1.4381 |
| Ring Count | : | 4 |
| Hydrogen Bond Acceptor Count | : | 14 |
| Hydrogen Bond Donor Count | : | 15 |
| Total Polar Surface Area | : | 431.54 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Thyroid Disorder | Thyroid peroxidase precursor (P07202) | Anti-TPO and anti-Tg antibodies gradually decreased during the clinical course@demonstrating the association of thyroid disorder with leuprolide injection. [ ADR Type 5 ] | Transient thyrotoxicosis and hypothyroidism following administration of the GnRH agonist leuprolide acetate |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category