InAADR

Drug Information

Drug Name: Peplomycin (PLM) (70384-29-1)
PubChem ID: 71751515
SMILES: CC1=C(N=C(N=C1N)C(CC(=O)N)NCC(C(=O)N)N)C(=O)NC(C(C2=CN=CN2)O[C@H]3[C@H]([C@H]([C@@H]([C@@H](O3)CO)O)O)O[C@@H]4[C@H]([C@H]([C@@H]([C@H](O4)CO)O)OC(=O)N)O)C(=O)NC(C)C(C(C)C(=O)NC(C(C)O)C(=O)NCCC5=NC(=CS5)C6=NC(=CS6)C(=O)NCCCN[C@H](C)C7=CC=CC=C7)O.OS(=O)(=O)
InchiKey: ZHHIHQFAUZZMTG-PZSJMQSLSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 1555.69
LogP: -7.15988
Ring Count: 5
Hydrogen Bond Acceptor Count: 34
Hydrogen Bond Donor Count: 23
Total Polar Surface Area: 693.47

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Pulmonary Fibrosis Collagen (P02452) Up-regulated RO and collagen generation are the causative factors of PLM-induced pulmonary fibrosis. [ ADR Type 2 ] Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
Pulmonary Fibrosis Granulocyte-macrophage colony-stimulating factor (P04141) In vitro, peplomycin(PLM) up-regulated the release of interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts,which are the causative factors of PLM-induced pulmonary fibrosis [ ADR Type 2 ] Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
Pulmonary Fibrosis Interleukin-1 beta (P01584) In vitro, peplomycin(PLM) up-regulated the release of interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts,which are the causative factors of PLM-induced pulmonary fibrosis. [ ADR Type 2 ] Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
Pulmonary Fibrosis Interleukin-6 precursor (P05231) In vitro@ peplomycin(PLM) up-regulated the release of interleukin-1 beta@ interleukin-6@ tumor necrosis factor alpha@ and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts@which are the causative factors of PLM-induced pulmonary fibrosis [ ADR Type 2 ] Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
Pulmonary Fibrosis Superoxide dismutase (P00441) In vitro, peplomycin(PLM) up-regulated the release of interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts,which are the causative factors of PLM-induced pulmonary fibrosis. [ ADR Type 2 ] Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts
Pulmonary Fibrosis Tumor necrosis factor precursor (P01375) In vitro, peplomycin(PLM) up-regulated the release of interleukin-1 beta, interleukin-6, tumor necrosis factor alpha, and granulocyte-macrophage colony-stimulating factor both from human cells and from RAM and pulmonary fibroblasts,which are the causative factors of PLM-induced pulmonary fibrosis. [ ADR Type 2 ] Contrasting influence of peplomycin and azelastine hydrochloride (Azeptin) on reactive oxygen generation in polymorphonuclear leukocytes, cytokine generation in lymphocytes, and collagen synthesis in fibroblasts

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source

InAADR: Drug-Protein-ADRs database