| Drug Name: | Mannitol (69-65-8) |
|---|---|
| PubChem ID: | 6251 |
| SMILES: | C([C@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O)O |
| InchiKey: | FBPFZTCFMRRESA-KVTDHHQDSA-N |
| Therapeutic Category: | Diuretics, Flavoring Agents, Food Additives, Natriuretic Agents, Sweetening Agents |
| Molecular Weight (dalton) | : | 182.172 |
| LogP | : | -3.5854 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 6 |
| Hydrogen Bond Donor Count | : | 6 |
| Total Polar Surface Area | : | 121.38 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Losartan (114798-26-4) | Renal Failure | Antagonistic | Not Understood | Mannitol-induced toxicity in a diabetic patient receiving losartan |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Apoptosis | Caspase-3 (P42574) | Mannitol induces the activation of caspases-3 and -9 in a time course similar to the dephosphorylation and degradation of FAK@which may lead to apoptosis [ ADR Type 2 ] | Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt |
| Apoptosis | Caspase-9 (P55211) | Mannitol induces the activation of caspases-3 and -9 in a time course similar to the dephosphorylation and degradation of FAK@which may lead to apoptosis [ ADR Type 2 ] | Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt |
| Apoptosis | Focal adhesion kinase (FAK) (Q05397) | One of the pathways of mannitol-mediated apoptosis is through the degradation of FAK and Akt and that IGF-I protects the cells from apoptosis by blocking the activation of caspases@ which may be responsible for the loss of FAK and Akt. [ ADR Type 2 ] | Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt |
| Apoptosis | RAC-alpha serine/threonine-protein kinase (P31749) | One of the pathways of mannitol-mediated apoptosis is through the degradation of FAK and Akt and that IGF-I protects the cells from apoptosis by blocking the activation of caspases@ which may be responsible for the loss of FAK and Akt [ ADR Type 2 ] | Insulin-like growth factor I prevents mannitol-induced degradation of focal adhesion kinase and Akt |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category