InAADR: Drug-Protein-ADRs database

Drug Name:	Encainide (66778-36-7)
PubChem ID:	48041
SMILES:	CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC
InchiKey:	PJWPNDMDCLXCOM-UHFFFAOYSA-N
Therapeutic Category:	Anti-Arrhythmia Agents, Cardiovascular Agents, Membrane Transport Modulators, Sodium Channel Blockers, Voltage-Gated Sodium Channel Blockers

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug	Toxicity	Interaction Type	Mechanism	Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity	Interacting Protein	Mechanism	Reference
Constipation	Kappa-Type opioid receptor (P41145)	Not Available	Large-scale prediction and testing of drug activity on side-effect targets
Death	Kappa-Type opioid receptor (P41145)	Not Available	Large-scale prediction and testing of drug activity on side-effect targets
Mental Disorder	Kappa-Type opioid receptor (P41145)	Not Available	Large-scale prediction and testing of drug activity on side-effect targets
Respiratory Disorder	Kappa-Type opioid receptor (P41145)	Not Available	Large-scale prediction and testing of drug activity on side-effect targets
Somnolence	Kappa-Type opioid receptor (P41145)	Not Available	Large-scale prediction and testing of drug activity on side-effect targets

This panel provides drug-food interactions and their ADRs along with references

Food	Toxicity	Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite	Toxicity	Place of Metabolism	Mechanism	Reference

This panel provides information on drug category

Toxicity	Source
Abdominal Pain	ADReCS
Abnormal Dreams	ADReCS
Abnormal Gait	ADReCS
Anorexia	ADReCS
Antinuclear Antibody Positive	ADReCS
Arrhythmia	ADReCS
Arrhythmias Cardiac	MetaADEDB
Arthralgia	ADReCS
Asthenia	ADReCS
Ataxia	ADReCS
Atrioventricular Block	ADReCS
Blood Alkaline Phosphatase Increased	ADReCS
Blood Insulin Increased	ADReCS
Blood Pressure Fluctuation	ADReCS
Bradycardia	ADReCS
Cardiac Failure Congestive	ADReCS
Chest Pain	ADReCS
Confusional State	ADReCS
Constipation	ADReCS
Cough	ADReCS
Death	ADReCS
Diarrhoea	ADReCS
Diplopia	ADReCS
Dizziness	ADReCS
Dry Mouth	ADReCS
Dysgeusia	ADReCS
Dyspepsia	ADReCS
Dyspnoea	ADReCS
Electrocardiogram Qrs Complex Prolonged	ADReCS
Headache	ADReCS
Heart Arrest	MetaADEDB
Heart Failure	MetaADEDB
Hepatic Enzyme Increased	ADReCS
Hepatitis	ADReCS
Insomnia	ADReCS
Jaundice	ADReCS
Leukopenia	ADReCS
Malaise	ADReCS
Nausea	ADReCS
Nervousness	ADReCS
Oedema Peripheral	ADReCS
Pain	ADReCS
Pain In Extremity	ADReCS
Palpitations	ADReCS
Paraesthesia	ADReCS
Periorbital Oedema	ADReCS
Photophobia	ADReCS
Pyrexia	ADReCS
Rash	ADReCS
Sensory Disturbance	ADReCS
Somnolence	ADReCS
Syncope	ADReCS
Tachycardia	MetaADEDB
Tachycardia Supraventricular	MetaADEDB
Tachycardia Ventricular	MetaADEDB
Thrombocytopenia	ADReCS
Tinnitus	ADReCS
Transaminases Increased	ADReCS
Tremor	ADReCS
Ventricular Extrasystoles	ADReCS
Ventricular Tachycardia	ADReCS
Vision Blurred	ADReCS
Visual Impairment	ADReCS
Vomiting	ADReCS

Molecular Weight (dalton)	:	352.478
LogP	:	4.3644
Ring Count	:	2
Hydrogen Bond Acceptor Count	:	3
Hydrogen Bond Donor Count	:	1
Total Polar Surface Area	:	41.57