| Drug Name: | Uracil Mustard (66-75-1) |
|---|---|
| PubChem ID: | 6194 |
| SMILES: | C1=C(C(=O)NC(=O)N1)N(CCCl)CCCl |
| InchiKey: | IDPUKCWIGUEADI-UHFFFAOYSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 252.101 |
| LogP | : | 0.3472 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 68.96 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
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This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Apoptosis | Poly [ADP-ribose] polymerase (Q9ZP54) | A significant correlation (r = 0.94) was observed between the compounds# ability to inhibit poly(ADP-ribose) polymerase (PADPRP) and the compounds# ability to reduce HD- induced cell death@ suggesting that poly(ADP-ribose) polymerase (PADPRP) plays a role in HD-induced cell death. [ ADR Type 1 ] | Effects of specific inhibitors of cellular functions on sulfur mustard-induced cell death |
| Cell Death | GPI-linked NAD (P)(+)--arginine ADP-ribosyltransferase (P52961) | In cultured human epidermal cells exposure to the vesicant sulfur mustard (HD) causes a decrease of the NAD+ content@this NAD+ loss is due to activation of the enzyme NAD:protein ADP-ribosyltransferase (ADPRT) and may lead to eventually cell death. [ ADR Type 1 ] | NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard |
| Delayed Inflammatory Skin Response | Granulocyte-macrophage colony-stimulating factor (P04141) | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta, GM-CSF, and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure,which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin |
| Delayed Inflammatory Skin Response | Interleukin-6 precursor (P05231) | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta@ GM-CSF@ and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure@which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin |
| Disturbance Of Energy Metabolism | GPI-linked NAD (P)(+)--arginine ADP-ribosyltransferase (P52961) | In cultured human epidermal cells exposure to the vesicant sulfur mustard (HD) causes a decrease of the NAD+ content@this NAD+ loss is due to activation of the enzyme NAD:protein ADP-ribosyltransferase (ADPRT) and may lead to disturbance of energy metabolism [ ADR Type 1 ] | NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard |
| Glycolysis Inhibition | GPI-linked NAD (P)(+)--arginine ADP-ribosyltransferase (P52961) | In cultured human epidermal cells exposure to the vesicant sulfur mustard (HD) causes a decrease of the NAD+ content@this NAD+ loss is due to activation of the enzyme NAD:protein ADP-ribosyltransferase (ADPRT) and may lead to glycolysis inhibition [ ADR Type 1 ] | NAD+ levels and glucose uptake of cultured human epidermal cells exposed to sulfur mustard |
| Severe Tissue Injury | Granulocyte-macrophage colony-stimulating factor (P04141) | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta, GM-CSF, and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure,which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin |
| Skin Tissue Injury | Interleukin-1 beta (P01584) | An increase in IL-1beta mRNA levels was first observed at 3 hours. IL-1beta, GM-CSF, and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure,which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury). [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin |
| Tissue Injury | Interleukin-6 precursor (P05231) | An increase in IL-1beta mRNA levels was first observed at 3 hours IL-1beta@ GM-CSF@ and IL-6 mRNA levels were dramatically increased at 6-24 hours postexposure@which is associated with HD-induced skin pathogenesis(delayed inflammatory skin response and severe tissue injury) [ ADR Type 5 ] | Alterations in inflammatory cytokine gene expression in sulfur mustard-exposed mouse skin |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category
| Toxicity | Source |
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