InAADR

Drug Information

Drug Name: Cyclosporine (59865-13-3)
PubChem ID: 123134270
SMILES: CC[C@H]1C(=O)N(CC(=O)N([C@@H](C(=O)N[C@H](C(=O)N([C@H](C(=O)N[C@H](C(=O)N[C@@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N([C@H](C(=O)N1)[C@@H]([C@H](C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C
InchiKey: PMATZTZNYRCHOR-RYZPDLMBSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 1202.63
LogP: 3.269
Ring Count: 0
Hydrogen Bond Acceptor Count: 12
Hydrogen Bond Donor Count: 5
Total Polar Surface Area: 278.8

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Doxorubicin (23214-92-8) Neurotoxicity Synergistic Uncertain,One reason may be that the ciclosporin affects the P-glycoprotein of the biliary tract so that the clearance of these anthracyclines in the bile is reduced Neurological symptoms and coma associated with doxorubicin administration during chronic cyclosporin therapy
Etoposide (33419-42-0) Hepatotoxicity Synergistic ciclosporin decreases the metabolism of the etoposide by inhibiting its metabolism by cytochrome P450 isoenzymes6 and inhibiting P-glycoprotein mediated efflux from the hepatocyte, A Study on the Metabolism of Etoposide and Possible Interactions with Antitumor or Supporting Agents by Human Liver Microsomes
Etoposide (33419-42-0) Mental Confusion Synergistic ciclosporin decreases the metabolism of the etoposide by inhibiting its metabolism by cytochrome P450 isoenzymes6 and inhibiting P-glycoprotein mediated efflux from the hepatocyte, A Study on the Metabolism of Etoposide and Possible Interactions with Antitumor or Supporting Agents by Human Liver Microsomes
Etoposide (33419-42-0) Toxicity Renal Synergistic ciclosporin decreases the metabolism of the etoposide by inhibiting its metabolism by cytochrome P450 isoenzymes6 and inhibiting P-glycoprotein mediated efflux from the hepatocyte, A Study on the Metabolism of Etoposide and Possible Interactions with Antitumor or Supporting Agents by Human Liver Microsomes
Irinotecan (97682-44-5) Diarrhea Synergistic The effects of ciclosporin on irinotecan may be due to inhibition of irinotecan and SN-38-related biliary transporters A phase I trial of pharmacologic modulation of irinotecan with cyclosporine and phenobarbital

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Bone Loss Osteocalcin (P02818) Parathyroid hormone (PTH) and osteocalcin (BGP) increased by 90% and 800% respectively between pretransplantation values and 18 months after transplantation,which suggest Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation. [ ADR Type 2 ] Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation
Bone Loss Parathyroid hormone (P01270) Parathyroid hormone (PTH) and osteocalcin (BGP) increased by 90% and 800% respectively between pretransplantation values and 18 months after transplantation,which suggest Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation [ ADR Type 2 ] Cyclosporine induces high bone turnover and may contribute to bone loss after heart transplantation
Csa-Induced Scarring In The Kidney Transforming growth factor beta (P01137) Transforming growth factor (TGF)-beta was shown to be upregulated along with matrix proteins in a model of CsA nephrotoxicity(CsA-induced scarring in the kidney) [ ADR Type 2 ] Cyclosporine nephropathy: pathophysiology and clinical impact
Hypertension Endothelin-1 (P05305) Chronic NEP inhibition may prevent the CysA-induced hypertension by decreasing local endothelin-1 synthesis. [ ADR Type 1 ] Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension
Hypertension Neprilysin (P08473) CysA increased plasma plasma neutral endopeptidase activity@indicating that chronic NEP inhibition may prevent the CysA-induced hypertension. [ ADR Type 1 ] Effects of chronic neutral endopeptidase inhibition in rats with cyclosporine-induced hypertension
Microangiopathic Hemolysis (Maha) Von Willebrand factor (P04275) Cyclosporine modulate von Willebrand factor release from cultured human endothelial cells,which is associated with microangiopathic hemolysis (MAHA). [ ADR Type 2 ] A Cyclosporine and cremaphor modulate von Willebrand factor release from cultured human endothelial cells
Nephrotoxicity Calcineurin (P63098) Cyclosporine A and FK506 nephrotoxicity may reflect renal-specific functions of calcineurin [ ADR Type 2 ] Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin
Thrombosis Thrombomodulin (P07204) Decrease in endothelial cell-dependent protein C activation induced by thrombomodulin by treatment with cyclosporine@thereby increasing the risk of thrombosis. [ ADR Type 2 ] Decrease in endothelial cell-dependent protein C activation induced by thrombomodulin by treatment with cyclosporine
Thrombotic Complications Of Bone Marrow Von Willebrand factor (P04275) Cyclosporine modulate von Willebrand factor release from cultured human endothelial cells,which is associated with thrombotic complications of bone marrow and renal transplantation [ ADR Type 2 ] A Cyclosporine and cremaphor modulate von Willebrand factor release from cultured human endothelial cells
Thrombotic Complications Of Renal Transplantation Von Willebrand factor (P04275) Cyclosporine modulate von Willebrand factor release from cultured human endothelial cells,which is associated with thrombotic complications of bone marrow and renal transplantation [ ADR Type 2 ] A Cyclosporine and cremaphor modulate von Willebrand factor release from cultured human endothelial cells

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Discomfort ADReCS
Abdominal Distension ADReCS
Abdominal Infection MetaADEDB
Abdominal Pain ADReCS
Abdominal Pain ADReCS
Abducens Nerve Diseases MetaADEDB
Abnormal Gait MetaADEDB
Abnormal Sensation In Eye MetaADEDB
Abscess ADReCS
Abscess Neck MetaADEDB
Acarodermatitis MetaADEDB
Accident MetaADEDB
Aching Joints MetaADEDB
Aching Muscles MetaADEDB
Acne ADReCS
Activities Of Daily Living Impaired MetaADEDB
Acute Coronary Syndrome ADReCS
Acute Graft Versus Host Disease MetaADEDB
Acute Graft Versus Host Disease In Intestine MetaADEDB
Acute Graft Versus Host Disease In Liver MetaADEDB
Acute Kidney Injury MetaADEDB
Acute Myeloblastic Leukemia MetaADEDB
Acute Pulmonary Oedema MetaADEDB
Acute Respiratory Distress Syndrome MetaADEDB
Acute Tubular Necrosis ADReCS
Addison Disease MetaADEDB
Adrenal Insufficiency MetaADEDB
Adynamic Ileus MetaADEDB
Affect Lability ADReCS
Agitation ADReCS
Alanine Aminotransferase Increased MetaADEDB
Alkalosis Hypochloraemic MetaADEDB
Allergic Dermatitis MetaADEDB
Alopecia ADReCS
Alpha Tumour Necrosis Factor Increased MetaADEDB
Altered State Of Consciousness ADReCS
Anaemia ADReCS
Anaemia Of Chronic Disease MetaADEDB
Anaesthesia MetaADEDB
Anaphylactic Shock ADReCS
Anaphylactoid Reaction ADReCS
Anemia MetaADEDB
Anemia Aplastic MetaADEDB
Anemia Hemolytic MetaADEDB
Anemia Hemolytic Autoimmune MetaADEDB
Angiitis MetaADEDB
Angioedema ADReCS
Angioplasty MetaADEDB
Anhedonia MetaADEDB
Anorexia ADReCS
Anti-Erythropoietin Antibody Positive MetaADEDB
Anticonvulsant Drug Level Increased MetaADEDB
Antithrombin Iii Decreased MetaADEDB
Anuria MetaADEDB
Anxiety ADReCS
Aplasia Pure Red Cell MetaADEDB
Arrhythmia ADReCS
Arterial Occlusive Disease MetaADEDB
Arterial Thrombosis Limb MetaADEDB
Arthralgia ADReCS
Arthritis Rheumatoid MetaADEDB
Arthropathy ADReCS
Ascites MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Aspergillosis MetaADEDB
Asthenia ADReCS
Asystole MetaADEDB
Ataxia ADReCS
Atonic Seizures MetaADEDB
Atrophy MetaADEDB
Autoimmune Hepatitis MetaADEDB
Automatism MetaADEDB
Autonomic Neuropathy ADReCS
Azotaemia ADReCS
Azotemia MetaADEDB
Back Ache MetaADEDB
Back Disorder MetaADEDB
Bacterial Infection ADReCS
Bacterial Pneumonia MetaADEDB
Bacterial Toxaemia MetaADEDB
Behcet Syndrome MetaADEDB
Bence Jones Protein Urine MetaADEDB
Benign Intracranial Hypertension ADReCS
Beta 2 Microglobulin Increased MetaADEDB
Biopsy Bone Abnormal MetaADEDB
Biopsy Liver MetaADEDB
Biopsy Lung MetaADEDB
Bipolar Disorder MetaADEDB
Bladder Inflammation MetaADEDB
Blepharoptosis MetaADEDB
Blindness ADReCS
Blindness Cortical ADReCS
Blood Albumin Increased MetaADEDB
Blood Amylase Increased MetaADEDB
Blood Beta-D-Glucan Increased MetaADEDB
Blood Bilirubin Increased MetaADEDB
Blood Blister MetaADEDB
Blood Chloride Decreased MetaADEDB
Blood Creatine Increased MetaADEDB
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Creatinine MetaADEDB
Blood Creatinine Increased ADReCS
Blood Culture Positive MetaADEDB
Blood Disorder ADReCS
Blood Immunoglobulin G Increased MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Pressure Systolic Increased MetaADEDB
Blood Stem Cell Transplant Failure MetaADEDB
Blood Triglycerides Increased ADReCS
Blood Urea Increased MetaADEDB
Blood Uric Acid Increased ADReCS
Body Temperature Increased ADReCS
Bone Debridement MetaADEDB
Bone Marrow Depression MetaADEDB
Bone Marrow Disorder MetaADEDB
Bone Marrow Failure MetaADEDB
Bone Marrow Toxicity MetaADEDB
Bone Marrow Transplant MetaADEDB
Brain Diseases MetaADEDB
Brain Diseases Metabolic MetaADEDB
Brain Herniation MetaADEDB
Brain Injuries MetaADEDB
Brain Oedema MetaADEDB
Breast Neoplasms MetaADEDB
Breast Pain ADReCS
Breath Sounds Abnormal ADReCS
Bronchial Haemorrhage MetaADEDB
Bronchial Ulceration MetaADEDB
Bronchitis ADReCS
Bronchoalveolar Lavage MetaADEDB
Bronchopneumonia MetaADEDB
Bronchospasm ADReCS
Bullous Eruption ADReCS
Burn Oesophageal MetaADEDB
Bursitis ADReCS
C-Reactive Protein Increased MetaADEDB
Caesarean Section MetaADEDB
Calcinosis MetaADEDB
Calcium Ionised Increased MetaADEDB
Candida Infection MetaADEDB
Candidiasis ADReCS
Candidiasis Of Mouth MetaADEDB
Capillary Leak Syndrome MetaADEDB
Carbohydrate Antigen 125 Increased MetaADEDB
Carcinoma Squamous Cell MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Acute MetaADEDB
Cardiac Flutter MetaADEDB
Cardiac Operation MetaADEDB
Cardioactive Drug Level MetaADEDB
Cardiomyopathies MetaADEDB
Cardiotoxicity MetaADEDB
Cardiovascular Disorder ADReCS
Catalepsy MetaADEDB
Cataract ADReCS
Catheterisation Cardiac MetaADEDB
Cd4 Lymphocytes Decreased MetaADEDB
Cell Transformation Neoplastic MetaADEDB
Cellulitis ADReCS
Central Nervous System Infections MetaADEDB
Cerebellar Ataxia ADReCS
Cerebral Artery Stenosis MetaADEDB
Cerebral Hemorrhage MetaADEDB
Cerebral Infarct MetaADEDB
Cerebral Ischaemia MetaADEDB
Cerebrovascular Disorders MetaADEDB
Cerebrovascular Spasm MetaADEDB
Chemotherapeutic Drug Level Increased MetaADEDB
Chest Pain ADReCS
Chest Tube Insertion MetaADEDB
Chills ADReCS
Cholangiolitis MetaADEDB
Cholangitis Sclerosing MetaADEDB
Cholecystectomies MetaADEDB
Cholelithiasis MetaADEDB
Cholestasis MetaADEDB
Chromosome Abnormality MetaADEDB
Chronic Allograft Nephropathy MetaADEDB
Chronic Graft Versus Host Disease MetaADEDB
Chronic Kidney Disease MetaADEDB
Chronic Lymphocytic Leukaemia Recurrent MetaADEDB
Chronic Lymphocytic Leukaemia Transformation MetaADEDB
Chronic Ulcerative Colitis MetaADEDB
Clostridial Infection MetaADEDB
Clostridium Difficile Toxin Test Positive MetaADEDB
Clotting MetaADEDB
Cmv Infection MetaADEDB
Cognition Disorders MetaADEDB
Colectomy Total MetaADEDB
Coma ADReCS
Complications Of Transplanted Kidney MetaADEDB
Complications Of Transplanted Liver MetaADEDB
Compression Fracture MetaADEDB
Concomitant Disease Progression MetaADEDB
Condition Aggravated MetaADEDB
Confusion MetaADEDB
Confusional State ADReCS
Congenital Nephrotic Syndrome Finnish Type MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Congenital Vesicoureteric Reflux MetaADEDB
Congestive Cardiomyopathy MetaADEDB
Conjunctival Deposit MetaADEDB
Conjunctival Hyperaemia ADReCS
Conjunctivitis ADReCS
Constipation ADReCS
Convulsion ADReCS
Coronary Artery Bypass MetaADEDB
Coronary Artery Restenosis MetaADEDB
Cough ADReCS
Cryptogenic Organising Pneumonia MetaADEDB
Csf Granulocyte Count Abnormal MetaADEDB
Csf Neutrophil Count Increased MetaADEDB
Cutaneous Candidiasis MetaADEDB
Cyst ADReCS
Cystitis MetaADEDB
Cytolytic Hepatitis ADReCS
Cytomegalovirus Antibody Positive MetaADEDB
Cytomegalovirus Antigen MetaADEDB
Cytomegalovirus Colitis MetaADEDB
Cytomegalovirus Syndrome ADReCS
Cytomegalovirus Test Positive MetaADEDB
Cytomegalovirus Viraemia MetaADEDB
Deafness ADReCS
Death ADReCS
Decreased Appetite ADReCS
Decreased Libido MetaADEDB
Delirium MetaADEDB
Demyelination MetaADEDB
Dental Alveolar Anomaly MetaADEDB
Dental Examination MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Depression ADReCS
Depressive Disorder MetaADEDB
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Device Related Infection MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus ADReCS
Diabetic Hyperosmolar Coma MetaADEDB
Diabetic Ulcer MetaADEDB
Dialysis MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diastolic Dysfunction MetaADEDB
Dilatation Ventricular MetaADEDB
Discomfort ADReCS
Disease Recurrence MetaADEDB
Dislocation MetaADEDB
Disorder Lung MetaADEDB
Disorder Of Globe MetaADEDB
Disorder Peripheral Vascular MetaADEDB
Disorder Renal MetaADEDB
Disorders Of Excessive Somnolence MetaADEDB
Disorders Of Lipid Metabolism MetaADEDB
Disorientation ADReCS
Disseminated Intravascular Coagulation MetaADEDB
Disturbance In Attention ADReCS
Disturbance In Sexual Arousal ADReCS
Diverticulosis MetaADEDB
Dizziness ADReCS
Drowsiness MetaADEDB
Drug Exposure During Pregnancy MetaADEDB
Drug Ineffective ADReCS
Drug Interaction MetaADEDB
Drug Interaction Potentiation MetaADEDB
Drug Resistance MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Mouth ADReCS
Dry Skin ADReCS
Duodenal Ulcer Perforation MetaADEDB
Duodenitis MetaADEDB
Dysgeusia ADReCS
Dysmenorrhea MetaADEDB
Dyspepsia ADReCS
Dysphagia ADReCS
Dyspnoea ADReCS
Dysstasia MetaADEDB
Dysuria ADReCS
Ear Ache MetaADEDB
Ear Disorder ADReCS
Ear Haemorrhage MetaADEDB
Eating Disorder MetaADEDB
Ebv Infection MetaADEDB
Eczema ADReCS
Edema Extremities MetaADEDB
Edentulous MetaADEDB
Ejection Fraction Decreased MetaADEDB
Electromyogram Abnormal MetaADEDB
Elevated Erythrocyte Sedimentation Rate MetaADEDB
Emotional Distress MetaADEDB
Enanthema ADReCS
Encephalitis MetaADEDB
Encephalitis Cytomegalovirus MetaADEDB
Encephalitis Viral MetaADEDB
Encephalopathy ADReCS
Endotracheal Intubation MetaADEDB
Engraftment Syndrome MetaADEDB
Enlarged Liver MetaADEDB
Enteritis MetaADEDB
Enterococcal Infection MetaADEDB
Epidermal Necrolysis Toxic MetaADEDB
Epistaxis ADReCS
Epstein-Barr Virus Associated Lymphoproliferative Disorder MetaADEDB
Eructation ADReCS
Erythema Dyschromicum Perstans MetaADEDB
Erythema Migrans MetaADEDB
Erythrodermic Psoriasis MetaADEDB
Erythropenia MetaADEDB
Escherichia Infection MetaADEDB
Escherichia Urinary Tract Infection MetaADEDB
Exanthema MetaADEDB
Excess Potassium MetaADEDB
Excessive Thirst MetaADEDB
Exfoliative Rash MetaADEDB
Extremity Necrosis MetaADEDB
Eye Diseases MetaADEDB
Eye Pain ADReCS
Eye Pruritus MetaADEDB
Eyelid Diseases MetaADEDB
Face Pain MetaADEDB
Facial Paralysis MetaADEDB
Fanconi Syndrome MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue ADReCS
Fatty Liver MetaADEDB
Febrile Neutropenia MetaADEDB
Feeding Tube Insertion MetaADEDB
Feeling Abnormal ADReCS
Feeling Hot ADReCS
Fever MetaADEDB
Fib MetaADEDB
Fibroadenoma Of Breast ADReCS
Fibrosis MetaADEDB
Fibrous Histiocytoma MetaADEDB
Finger Amputation MetaADEDB
Flatulence ADReCS
Fluid Overload MetaADEDB
Flushing ADReCS
Folliculitis ADReCS
Food Interaction MetaADEDB
Fungaemia MetaADEDB
Fungal Disease MetaADEDB
Fungal Infection ADReCS
Fungal Test Positive MetaADEDB
Gastric Ulcer ADReCS
Gastritis ADReCS
Gastroenteritis ADReCS
Gastroenteritis Clostridial MetaADEDB
Gastroenteritis Rotavirus MetaADEDB
Gastrointestinal Diseases MetaADEDB
Gastrointestinal Disorder ADReCS
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Pain ADReCS
Gastrointestinal Stromal Tumour MetaADEDB
General Physical Health Deterioration MetaADEDB
Genital Discharge ADReCS
Gingival Bleeding ADReCS
Gingival Disorder ADReCS
Gingival Hyperplasia ADReCS
Gingival Hypertrophy MetaADEDB
Gingival Overgrowth MetaADEDB
Gingivitis ADReCS
Globulinuria MetaADEDB
Glomerulosclerosis Focal Segmental MetaADEDB
Glossitis ADReCS
Glucose Intolerance MetaADEDB
Goitre ADReCS
Gout ADReCS
Gouty Tophus MetaADEDB
Graft Infection MetaADEDB
Graft Loss ADReCS
Graft Vs Host Disease MetaADEDB
Grip Strength MetaADEDB
Guillain-Barre Syndrome MetaADEDB
Gynaecomastia ADReCS
Haematoma Evacuation MetaADEDB
Haematuria ADReCS
Haemodialysis MetaADEDB
Haemoglobin ADReCS
Haemoglobin Increased MetaADEDB
Haemolysis MetaADEDB
Haemolytic Anaemia ADReCS
Haemolytic Uraemic Syndrome ADReCS
Haemorrhage ADReCS
Haemosiderosis MetaADEDB
Hallucinations MetaADEDB
Headache ADReCS
Hearing Disorders MetaADEDB
Hearing Impaired ADReCS
Hearing Loss Sensorineural MetaADEDB
Heart Diseases MetaADEDB
Heart Sounds Abnormal ADReCS
Heart Transplant MetaADEDB
Helicobacter Infection MetaADEDB
Helicobacter Pylori Identification Test Positive MetaADEDB
Hematoma Subdural MetaADEDB
Hematuria MetaADEDB
Hemianopia MetaADEDB
Hemiplegia MetaADEDB
Hemoglobinuria Paroxysmal MetaADEDB
Hemolytic-Uremic Syndrome MetaADEDB
Hemorrhage MetaADEDB
Hemostatic Disorders MetaADEDB
Hepatic Atrophy MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Enzyme Abnormal MetaADEDB
Hepatic Failure MetaADEDB
Hepatic Function Abnormal ADReCS
Hepatic Trauma MetaADEDB
Hepatic Veno-Occlusive Disease MetaADEDB
Hepatitis MetaADEDB
Hepatitis B Chronic MetaADEDB
Hepatitis B Positive MetaADEDB
Hepatitis C MetaADEDB
Hepatocellular Damage MetaADEDB
Hepatocellular Injury ADReCS
Hepatosplenomegaly MetaADEDB
Hepatotoxicity ADReCS
Herpes Simplex ADReCS
Herpes Simplex Serology Positive MetaADEDB
Herpes Virus Infection ADReCS
Herpes Zoster ADReCS
Herpes Zoster Disseminated MetaADEDB
Hiccough MetaADEDB
Hiccups ADReCS
Hip Fracture MetaADEDB
Hirsutism ADReCS
Histiocytosis Haematophagic MetaADEDB
Hot Flush ADReCS
Human Herpesvirus 6 Infection MetaADEDB
Hyperaemia ADReCS
Hyperaesthesia ADReCS
Hyperalbuminaemia MetaADEDB
Hyperbilirubinaemia ADReCS
Hyperbilirubinemia MetaADEDB
Hypercholesterolemia MetaADEDB
Hyperglycaemia ADReCS
Hyperhidrosis ADReCS
Hyperkalaemia ADReCS
Hyperkalemia MetaADEDB
Hyperkeratosis ADReCS
Hyperlipaemia MetaADEDB
Hyperlipidaemia ADReCS
Hyperlipidemias MetaADEDB
Hyperparathyroidism MetaADEDB
Hyperpigmentation MetaADEDB
Hyperplasia ADReCS
Hyperprolactinemia MetaADEDB
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertension Renal MetaADEDB
Hypertrichosis ADReCS
Hypertriglyceridaemia ADReCS
Hypertriglyceridemia MetaADEDB
Hypertrophy ADReCS
Hypertrophy Left Ventricular MetaADEDB
Hyperuricaemia ADReCS
Hyperuricemia MetaADEDB
Hypoaesthesia ADReCS
Hypocholesterolaemia ADReCS
Hypoglycaemia ADReCS
Hypokalaemia MetaADEDB
Hypomagnesaemia ADReCS
Hypopituitarism MetaADEDB
Hypoproteinaemia MetaADEDB
Hyporeflexia MetaADEDB
Hypotrichosis ADReCS
Hypoxia MetaADEDB
Ill-Defined Disorder ADReCS
Immune System Diseases MetaADEDB
Immunosuppressant Drug Level MetaADEDB
Immunosuppressant Drug Level Decreased MetaADEDB
Immunosuppression MetaADEDB
Impatience MetaADEDB
Impetigo MetaADEDB
Incisional Hernia MetaADEDB
Incontinence ADReCS
Increased Appetite ADReCS
Increased White Blood Cell Count MetaADEDB
Induced Labour MetaADEDB
Infarction ADReCS
Infected Skin Ulcer MetaADEDB
Infection ADReCS
Infection Susceptibility Increased MetaADEDB
Infection Urinary Tract MetaADEDB
Influenza ADReCS
Infusion Related Reaction MetaADEDB
Infusion Site Mobility Decreased MetaADEDB
Insomnia ADReCS
Intentional Drug Misuse MetaADEDB
Interleukin Level Increased MetaADEDB
Interleukin-2 Receptor Increased MetaADEDB
Intestinal Diseases MetaADEDB
Intestinal Perforation MetaADEDB
Intestinal Resection MetaADEDB
Intestinal Ulcer Perforation MetaADEDB
Intra-abdominal haematoma MetaADEDB
Intra-Abdominal Haemorrhage MetaADEDB
Intracranial Pressure Increased ADReCS
Intraocular Lens Implant MetaADEDB
Intubation MetaADEDB
Iris Disorder MetaADEDB
Ischaemia ADReCS
Jaw Fracture MetaADEDB
Jaw Operation MetaADEDB
Jc Virus Infection MetaADEDB
Joint Abscess MetaADEDB
Joint Contracture MetaADEDB
Joint Crepitation MetaADEDB
Joint Range Of Motion Decreased MetaADEDB
Kaposi Sarcoma MetaADEDB
Keratoconjunctivitis Sicca MetaADEDB
Kidney Diseases MetaADEDB
Kidney Fibrosis MetaADEDB
Kidney Neoplasms MetaADEDB
Kidney Transplant MetaADEDB
Kidney Transplant Rejection MetaADEDB
Kidney Tubular Necrosis Acute MetaADEDB
Klebsiella Infection MetaADEDB
Knee Deformity MetaADEDB
Kyphoscoliosis MetaADEDB
Lacrimation Increased ADReCS
Leg Cramps ADReCS
Lentigo Maligna Stage Unspecified MetaADEDB
Lethargy ADReCS
Leucopenia MetaADEDB
Leukoaraiosis MetaADEDB
Leukocyturia MetaADEDB
Leukoencephalopathies MetaADEDB
Leukoencephalopathy Progressive Multifocal MetaADEDB
Leukopenia ADReCS
Leukopenia Neonatal MetaADEDB
Leukorrhea ADReCS
Libido Decreased ADReCS
Libido Increased ADReCS
Lichen Planus MetaADEDB
Life Support MetaADEDB
Limb Operation MetaADEDB
Liver Diseases MetaADEDB
Liver Failure Acute MetaADEDB
Liver Injury ADReCS
Liver Transplant MetaADEDB
Local Swelling MetaADEDB
Logorrhoea MetaADEDB
Loss Of Weight MetaADEDB
Lung Consolidation MetaADEDB
Lung Edema MetaADEDB
Lung Infiltration MetaADEDB
Lung Transplant MetaADEDB
Lymphadenopathy ADReCS
Lymphoma ADReCS
Lymphoproliferative Disorder ADReCS
Malaise ADReCS
Malnourished MetaADEDB
Marasmus MetaADEDB
Mechanical Ventilation MetaADEDB
Meningitides MetaADEDB
Meningococcal Sepsis MetaADEDB
Menopausal Symptoms ADReCS
Menstrual Disorder ADReCS
Mental Disability ADReCS
Mental Disorders MetaADEDB
Mesenteric Occlusion MetaADEDB
Metabolic Acidosis MetaADEDB
Metal Metabolism Inborn Errors MetaADEDB
Microangiopathic Haemolytic Anaemia ADReCS
Microangiopathy ADReCS
Micturition Urgency ADReCS
Middle Ear Inflammation MetaADEDB
Migraine ADReCS
Mitochondrial Myopathy Acquired MetaADEDB
Mitral Valve Replacement MetaADEDB
Mood Swings ADReCS
Mouth Ulcer MetaADEDB
Movement Disorders MetaADEDB
Mucormycosis MetaADEDB
Mucosal Inflammation MetaADEDB
Mucositis MetaADEDB
Multi-Organ Failure MetaADEDB
Multifocal Leukoencephalopathy MetaADEDB
Muscle Contractions Involuntary ADReCS
Muscle Fatigue MetaADEDB
Muscle Spasms ADReCS
Muscle Weakness MetaADEDB
Muscular Diseases MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Stiffness ADReCS
Myalgia ADReCS
Myasthenia Gravis MetaADEDB
Mycobacterium Chelonei Infection MetaADEDB
Mycobacterium Tuberculosis Infection MetaADEDB
Myeloblastoma MetaADEDB
Myelodysplasia MetaADEDB
Myeloma Recurrence MetaADEDB
Myocardial Infarction ADReCS
Myoglobin Blood Increased MetaADEDB
Myopathy ADReCS
Myopathy Toxic MetaADEDB
Myositis ADReCS
Nail Disorder ADReCS
Nasopharyngitis MetaADEDB
Nausea ADReCS
Necrosis ADReCS
Neoplasm ADReCS
Neoplasm Malignant ADReCS
Nephritis Interstitial MetaADEDB
Nephrocalcinosis MetaADEDB
Nephrogenic Fibrosing Dermopathy MetaADEDB
Nephropathy Toxic ADReCS
Nephrosis Lipoid MetaADEDB
Nephrotic Syndrome MetaADEDB
Nerve Degeneration MetaADEDB
Nervous System Diseases MetaADEDB
Nervousness ADReCS
Neumonia MetaADEDB
Neuralgia MetaADEDB
Neuromuscular Diseases MetaADEDB
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Neurotoxicity Syndromes MetaADEDB
Neutropenia MetaADEDB
Neutrophilia MetaADEDB
Night Sweats ADReCS
Nightmare ADReCS
No Therapeutic Response MetaADEDB
Nocturia ADReCS
Nodule On Extremity MetaADEDB
Non-Hodgkin Lymphoma MetaADEDB
Non-Obstructive Cardiomyopathy MetaADEDB
Nuclear Magnetic Resonance Imaging Brain Abnormal MetaADEDB
Obesity MetaADEDB
Obstruction ADReCS
Obstructive Airways Disorder MetaADEDB
Oedema ADReCS
Oedema Due To Cardiac Disease MetaADEDB
Oesophagitis ADReCS
Oliguria MetaADEDB
Onychoclasis ADReCS
Oophorectomy MetaADEDB
Ophthalmoplegia MetaADEDB
Optic Disc Edema MetaADEDB
Optic Neuritis ADReCS
Oral Disorder ADReCS
Oropharyngeal Pain MetaADEDB
Osteoarthritis ADReCS
Osteolysis MetaADEDB
Osteomyelitis MetaADEDB
Osteopenia MetaADEDB
Osteosclerosis MetaADEDB
Ovarian Neoplasms MetaADEDB
Pain ADReCS
Pain Intractable MetaADEDB
Pain Of Skin MetaADEDB
Pancreatitis ADReCS
Pancreatitis Chronic MetaADEDB
Papilloedema ADReCS
Paraesthesia ADReCS
Paralysis MetaADEDB
Paraproteinaemia MetaADEDB
Paresis ADReCS
Paresthesia MetaADEDB
Paronychia MetaADEDB
Parvovirus B19 Serology Positive MetaADEDB
Pathogen Resistance MetaADEDB
Pelvic Haematoma MetaADEDB
Pemphigus MetaADEDB
Penile Oedema MetaADEDB
Peptic Ulcer ADReCS
Peripheral Arterial Occlusive Disease MetaADEDB
Peripheral Ischaemia ADReCS
Peripheral Nervous System Diseases MetaADEDB
Personality Change MetaADEDB
Petechia MetaADEDB
Pharyngeal Erythema MetaADEDB
Pharyngitis ADReCS
Pigmentation Disorder ADReCS
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pleural Fibrosis MetaADEDB
Pneumocystis Jiroveci Pneumonia MetaADEDB
Pneumonia ADReCS
Pneumonia Cytomegaloviral MetaADEDB
Pneumonia Fungal MetaADEDB
Pollakiuria ADReCS
Polyneuropathy ADReCS
Polyuria ADReCS
Portal Vein Occlusion MetaADEDB
Portal Vein Thrombosis MetaADEDB
Post Procedural Discomfort MetaADEDB
Posterior Leukoencephalopathy Syndrome MetaADEDB
Postoperative Complications MetaADEDB
Precancerous Conditions MetaADEDB
Precursor Cell Lymphoblastic Leukemia-Lymphoma MetaADEDB
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma MetaADEDB
Premature Baby MetaADEDB
Premature Labour MetaADEDB
Procedural Pain MetaADEDB
Proteinuria MetaADEDB
Protozoan Infections Animal MetaADEDB
Pruritus ADReCS
Pseudarthrosis MetaADEDB
Pseudomonas Infection MetaADEDB
Psoriasis MetaADEDB
Psychomotor Skills Impaired MetaADEDB
Pulmonary Alveolar Haemorrhage MetaADEDB
Pulmonary Congestion MetaADEDB
Pulmonary Embolism MetaADEDB
Pulmonary Hypertension MetaADEDB
Purpura ADReCS
Purpura Thrombocytopenic Idiopathic MetaADEDB
Purpura Thrombotic Thrombocytopenic MetaADEDB
Purulent Discharge MetaADEDB
Pustular Psoriasis MetaADEDB
Pyelonephritis ADReCS
Pyrexia ADReCS
Quadriplegia MetaADEDB
Rash ADReCS
Rectal Haemorrhage ADReCS
Recurrence MetaADEDB
Red Blood Cell Schistocytes Present MetaADEDB
Renal Abscess ADReCS
Renal Disorder ADReCS
Renal Failure ADReCS
Renal Haematoma MetaADEDB
Renal Impairment ADReCS
Renal Insufficiency MetaADEDB
Renal Tubular Atrophy MetaADEDB
Renal Tubular Disorder ADReCS
Renal Tubular Necrosis ADReCS
Reperfusion Injury MetaADEDB
Respiratory Disorder ADReCS
Respiratory Failure MetaADEDB
Respiratory Tract Infection ADReCS
Reticulocyte Count Increased MetaADEDB
Retinal Vein Occlusion MetaADEDB
Rhabdomyolysis ADReCS
Rhinitis ADReCS
Rib Fracture MetaADEDB
Salivary Gland Enlargement ADReCS
Scar MetaADEDB
Scleroderma MetaADEDB
Scleroderma Localized MetaADEDB
Scleroderma Renal Crisis MetaADEDB
Scoliosis MetaADEDB
Seizures MetaADEDB
Sensation Of Foreign Body ADReCS
Sensory Loss MetaADEDB
Sepsis ADReCS
Sepsis Syndrome MetaADEDB
Septic Shock MetaADEDB
Serotonin Syndrome MetaADEDB
Shock MetaADEDB
Sinusitis ADReCS
Skin Cancer ADReCS
Skin Desquamation MetaADEDB
Skin Discolouration ADReCS
Skin Disorder ADReCS
Skin Hypertrophy MetaADEDB
Skin Induration MetaADEDB
Skin Infection ADReCS
Skin Plaque MetaADEDB
Skin Swelling MetaADEDB
Skin Tightness MetaADEDB
Skin Ulcer ADReCS
Small For Dates Baby MetaADEDB
Small Intestinal Haemorrhage MetaADEDB
Soft Tissue Disorder MetaADEDB
Somnolence ADReCS
Spermatic Cord Torsion MetaADEDB
Spermatozoa Progressive Motility Abnormal MetaADEDB
Spermatozoa Progressive Motility Decreased MetaADEDB
Spinal Compression Fracture MetaADEDB
Spinal X-Ray MetaADEDB
Spondyloarthropathy MetaADEDB
Status Epilepticus MetaADEDB
Stem Cell Transplant MetaADEDB
Stenotrophomonas Infection MetaADEDB
Steroid Withdrawal Syndrome MetaADEDB
Stomatitis ADReCS
Stomatitis Aphthous MetaADEDB
Streptococcal Bacteraemia MetaADEDB
Subcutaneous Nodule MetaADEDB
Subileus MetaADEDB
Substance Withdrawal Syndrome MetaADEDB
Synovial Cyst ADReCS
Systemic Mycosis MetaADEDB
Tendon Disorder ADReCS
Tension ADReCS
Therapeutic Response Decreased MetaADEDB
Thrombectomy MetaADEDB
Thrombocytopenia ADReCS
Thromboembolism MetaADEDB
Thrombosis ADReCS
Thrombosis In Device MetaADEDB
Thrombotic Microangiopathies MetaADEDB
Tinea Blanca MetaADEDB
Tinnitus ADReCS
Toe Amputation MetaADEDB
Tongue Disorder ADReCS
Tonsillitis ADReCS
Tooth Disorder ADReCS
Toxoplasmosis MetaADEDB
Tracheal Ulcer MetaADEDB
Tracheobronchitis MetaADEDB
Tracheostomy MetaADEDB
Transplant Failure ADReCS
Treatment Noncompliance MetaADEDB
Tremor ADReCS
Trichorrhexis ADReCS
Tuberculin Test Positive MetaADEDB
Tuberculosis Test Positive MetaADEDB
Ulcer ADReCS
Upper Gastrointestinal Haemorrhage ADReCS
Upper Respiratory Tract Infection ADReCS
Upper Respiratory Tract Inflammation MetaADEDB
Urinary Casts MetaADEDB
Urinary Incontinence ADReCS
Urinary Tract Infection ADReCS
Urinary Tract Infection Enterococcal MetaADEDB
Urinary Tract Infection Pseudomonal MetaADEDB
Urine Abnormality ADReCS
Urine Analysis Abnormal ADReCS
Urine Ketone Body Present MetaADEDB
Urine Output Increased ADReCS
Urosepsis MetaADEDB
Urticaria ADReCS
Uterine Haemorrhage ADReCS
Uveitis MetaADEDB
Uveitis Posterior MetaADEDB
Vacuolar Myopathy MetaADEDB
Varicella Zoster Virus Serology Positive MetaADEDB
Vascular Diseases MetaADEDB
Vascular Purpura ADReCS
Vein Disorder MetaADEDB
Venoocclusive Disease MetaADEDB
Venous Thrombosis MetaADEDB
Vertigo ADReCS
Vestibular Disorder ADReCS
Viral Dna Test Positive MetaADEDB
Viral Infection ADReCS
Vision Blurred ADReCS
Vision Disorders MetaADEDB
Visual Acuity Reduced ADReCS
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vocal Cord Paresis MetaADEDB
Vomiting ADReCS
Walking Aid User MetaADEDB
Wegener Granulomatosis MetaADEDB
Weight Decreased ADReCS
Weight Increased ADReCS
X-Linked Lymphoproliferative Syndrome ADReCS
Xerophthalmia MetaADEDB

InAADR: Drug-Protein-ADRs database