InAADR

Drug Information

Drug Name: Levothyroxine (51-48-9)
PubChem ID: 5819
SMILES: C1=C(C=C(C(=C1I)OC2=CC(=C(C(=C2)I)O)I)I)C[C@@H](C(=O)O)N
InchiKey: XUIIKFGFIJCVMT-LBPRGKRZSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 776.872
LogP: 4.5573
Ring Count: 2
Hydrogen Bond Acceptor Count: 4
Hydrogen Bond Donor Count: 3
Total Polar Surface Area: 92.78

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit juice Delay The Absorption Food-Drug Interactions

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Cramp ADReCS
Abdominal Cramp MetaADEDB
Abdominal Discomfort MetaADEDB
Abdominal Pain ADReCS
Abdominal Pain MetaADEDB
Abnormal Behaviour MetaADEDB
Abnormal Cervical Smear MetaADEDB
Abnormal Ecg MetaADEDB
Abnormal Gait MetaADEDB
Abnormal Lfts MetaADEDB
Abscess Oral MetaADEDB
Accidental Overdose MetaADEDB
Aching Joints MetaADEDB
Aching Muscles MetaADEDB
Acid Reflux MetaADEDB
Actinomycosis MetaADEDB
Acute Kidney Injury MetaADEDB
Acute Leukaemia MetaADEDB
Acute Respiratory Failure MetaADEDB
Adrenal Neoplasm MetaADEDB
Affect Lability ADReCS
Afib MetaADEDB
Ageusia MetaADEDB
Allergic Dermatitis MetaADEDB
Alopecia ADReCS
Amyotrophy MetaADEDB
Anaemia MetaADEDB
Anaesthesia MetaADEDB
Anastomotic Ulcer MetaADEDB
Anemia MetaADEDB
Anemia Hemolytic Autoimmune MetaADEDB
Angina Pectoris ADReCS
Angina Unstable MetaADEDB
Angioedema ADReCS
Angiopathy MetaADEDB
Anorexia MetaADEDB
Anosmia MetaADEDB
Anuria MetaADEDB
Anxiety ADReCS
Aphonia MetaADEDB
Apoplexy MetaADEDB
Aptyalism MetaADEDB
Arrhythmia ADReCS
Arrhythmias Cardiac MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Arthralgia ADReCS
Arthritis MetaADEDB
Arthrodesis MetaADEDB
Arthropathy MetaADEDB
Arthropod Bite MetaADEDB
Assisted Fertilisation ADReCS
Asthenia ADReCS
Ataxia MetaADEDB
Atrial Tachycardia MetaADEDB
Atrioventricular Block MetaADEDB
Atrioventricular Block First Degree MetaADEDB
Atrophy MetaADEDB
Back Ache MetaADEDB
Balance Disorder MetaADEDB
Barrett Oesophagus MetaADEDB
Basal Cell Carcinoma MetaADEDB
Basedow Disease ADReCS
Benign Intracranial Hypertension ADReCS
Benign Vascular Neoplasm MetaADEDB
Beta Haemolytic Streptococcal Infection MetaADEDB
Blood Calcium Increased MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Pressure Increased ADReCS
Blood Sodium MetaADEDB
Blood Test Abnormal MetaADEDB
Blood Triglycerides MetaADEDB
Blurred Vision MetaADEDB
Body Height Abnormal ADReCS
Body Temperature Increased ADReCS
Bone Debridement MetaADEDB
Bone Density Decreased ADReCS
Bone Disorder MetaADEDB
Bone Pain MetaADEDB
Bone Scan Abnormal MetaADEDB
Bone Spur MetaADEDB
Bradypnoea MetaADEDB
Brain Concussion MetaADEDB
Brain Oedema MetaADEDB
Breast Cancer In Situ MetaADEDB
Bronchitis MetaADEDB
Bruise MetaADEDB
Bulging MetaADEDB
Burning Sensation MetaADEDB
Calcium Ionised Increased MetaADEDB
Calculus Bladder MetaADEDB
Cancer MetaADEDB
Cardiac Arrest ADReCS
Cardiac Decompensation MetaADEDB
Cardiac Enzymes Increased MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Congestive ADReCS
Cardiomegaly MetaADEDB
Cardiospasm MetaADEDB
Carotid Artery Stenosis MetaADEDB
Carotid Artery Stent Insertion MetaADEDB
Carpal Tunnel Syndrome MetaADEDB
Cataract MetaADEDB
Cell Marker Increased MetaADEDB
Cellulitis MetaADEDB
Cerebral Artery Embolism ADReCS
Cerebral Thrombosis MetaADEDB
Chest Pain MetaADEDB
Choking ADReCS
Choking Sensation MetaADEDB
Cholecystectomies MetaADEDB
Chondromalacia MetaADEDB
Chronic Kidney Disease MetaADEDB
Chronic Obstructive Airway Disease MetaADEDB
Chronic Obstructive Airways Disease Exacerbated MetaADEDB
Chronic Respiratory Failure MetaADEDB
Confabulation MetaADEDB
Confusional State ADReCS
Congenital Mitral Valve Incompetence MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Conjunctival Deposit MetaADEDB
Constipated MetaADEDB
Conversion Disorder MetaADEDB
Convulsion ADReCS
Coronary Artery Restenosis MetaADEDB
Cough MetaADEDB
Coughing Blood MetaADEDB
Crackles Lung MetaADEDB
Cramp Muscle MetaADEDB
Craniosynostosis ADReCS
Cutaneous Ulcer MetaADEDB
Death ADReCS
Dehydration ADReCS
Delirium MetaADEDB
Delirium Dementia Amnestic Cognitive Disorders MetaADEDB
Demyelination MetaADEDB
Dental Abscess MetaADEDB
Dental Care MetaADEDB
Dental Caries MetaADEDB
Dental Fistula MetaADEDB
Dental Operation MetaADEDB
Depressive Disorder Major MetaADEDB
Dermatitis ADReCS
Diabetes MetaADEDB
Diabetic Neuropathy MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diastolic Dysfunction MetaADEDB
Dilatation Atrial MetaADEDB
Discomfort ADReCS
Disorder Renal MetaADEDB
Disorientation ADReCS
Diverticular Perforation MetaADEDB
Dizziness MetaADEDB
Dizziness Exertional MetaADEDB
Drug Dose Omission MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Skin MetaADEDB
Duodenitis MetaADEDB
Dysphagia ADReCS
Dysphonia MetaADEDB
Dyspnea Exertional MetaADEDB
Dyspnoea ADReCS
Dysthymic Disorder MetaADEDB
Ear Ache MetaADEDB
Early Morning Awakening MetaADEDB
Easy Bruisability MetaADEDB
Ebv Infection MetaADEDB
Edema Extremities MetaADEDB
Effusion MetaADEDB
Ejection Fraction Decreased MetaADEDB
Electrocardiogram Qt Corrected Interval Prolonged MetaADEDB
Embolism ADReCS
Emotional Distress MetaADEDB
Encephalopathy MetaADEDB
Endodontic Procedure MetaADEDB
Enterococcal Infection MetaADEDB
Enzyme Abnormality MetaADEDB
Epiphyseal Disorder ADReCS
Epiphyses Premature Fusion ADReCS
Epiphysiolysis ADReCS
Excoriation MetaADEDB
Extremity Pain MetaADEDB
Eye Pain MetaADEDB
Facial Flushing MetaADEDB
Facial Palsy MetaADEDB
Fatigue ADReCS
Feeling Abnormal ADReCS
Femoral Neck Fracture MetaADEDB
Femur Fracture MetaADEDB
Fertilization SIDER
Fib MetaADEDB
Fibroids MetaADEDB
Fibroma MetaADEDB
Fibromyalgia MetaADEDB
Flat Affect MetaADEDB
Flu MetaADEDB
Fluid Loss SIDER
Flushing ADReCS
Food Allergy MetaADEDB
Food Poisoning MetaADEDB
Foot Deformity MetaADEDB
Fracture Nonunion MetaADEDB
Friedreich Ataxia MetaADEDB
Gagging SIDER
Gallbladder Diseases MetaADEDB
Ganglion MetaADEDB
Gastric Disorder ADReCS
Gastroenteritis Eosinophilic MetaADEDB
Gastrointestinal Disorder ADReCS
Gastrointestinal Pain ADReCS
Gastrointestinal Stoma Complication MetaADEDB
Generalised Anxiety Disorder MetaADEDB
Genital Burning Sensation MetaADEDB
Glucose Intolerance MetaADEDB
Glycosylated Haemoglobin Increased MetaADEDB
Goiter MetaADEDB
Goiter Nodular MetaADEDB
Graves Disease MetaADEDB
Haemorrhoids MetaADEDB
Hashimoto Disease MetaADEDB
Headache ADReCS
Heart Rate Increased MetaADEDB
Heat Intolerance ADReCS
Hemiparesis MetaADEDB
Hemoglobinuria MetaADEDB
Hepatitis MetaADEDB
Hernia Hiatal MetaADEDB
Hernia Repair MetaADEDB
Hip Fracture MetaADEDB
Hodgkin Disease MetaADEDB
Hospitalisation MetaADEDB
Hot Flash MetaADEDB
Hyperbaric Oxygen Therapy MetaADEDB
Hypercholesterolemia MetaADEDB
Hyperhidrosis ADReCS
Hyperkeratosis MetaADEDB
Hyperlipaemia MetaADEDB
Hypertension MetaADEDB
Hyperthyroxinemia MetaADEDB
Hypertonic Bladder MetaADEDB
Hypertrichosis MetaADEDB
Hypochromasia MetaADEDB
Hypoglycaemia ADReCS
Hypokalaemia MetaADEDB
Hypopituitarism MetaADEDB
Hyporeflexia MetaADEDB
Hypotension Orthostatic MetaADEDB
Hypothyroid MetaADEDB
Hypothyroidism MetaADEDB
Hypovolaemia MetaADEDB
Ill-Defined Disorder ADReCS
Immune System Disorder MetaADEDB
Impaired Gastric Emptying MetaADEDB
Incoherent MetaADEDB
Incorrect Drug Administration Duration MetaADEDB
Increased Appetite ADReCS
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Infectious Mononucleosis MetaADEDB
Infertility ADReCS
Infusion Site Mobility Decreased MetaADEDB
Injection Site Dermatitis MetaADEDB
Injection Site Erythema MetaADEDB
Injection Site Urticaria MetaADEDB
Insomnia ADReCS
Intention Tremor MetaADEDB
Intervertebral Disc Degeneration MetaADEDB
Intervertebral Disc Disorder MetaADEDB
Intervertebral Disc Herniation MetaADEDB
Intestinal Obstruction MetaADEDB
Intraventricular Haemorrhage MetaADEDB
Iron Deficiency Anaemia MetaADEDB
Irregular Menstrual Cycle MetaADEDB
Irritability ADReCS
Ischaemic Cardiomyopathy MetaADEDB
Itch MetaADEDB
Jaw Disorder MetaADEDB
Joint Instability MetaADEDB
Joint Range Of Motion Decreased MetaADEDB
Joint Stiffness MetaADEDB
Jugular Vein Thrombosis MetaADEDB
Kidney Diseases MetaADEDB
Klebsiella Infection MetaADEDB
Lacunar Infarction MetaADEDB
Ligament Injury MetaADEDB
Limb Discomfort MetaADEDB
Limb Injury MetaADEDB
Lip Disorder MetaADEDB
Liver Diseases MetaADEDB
Liver Failure Acute MetaADEDB
Liver Function Test Abnormal ADReCS
Local Swelling MetaADEDB
Loss Of Weight MetaADEDB
Low Turnover Osteopathy MetaADEDB
Lumbar Radiculopathy MetaADEDB
Lung Fibrosis MetaADEDB
Lymphadenectomy MetaADEDB
Lymphedema MetaADEDB
Lymphocyte Count Decreased MetaADEDB
Lymphoma MetaADEDB
Malaise ADReCS
Mass ADReCS
Menopausal Symptoms MetaADEDB
Menstruation Irregular ADReCS
Mental Status Changes MetaADEDB
Metamorphopsia MetaADEDB
Metastases To Lung MetaADEDB
Microcytosis MetaADEDB
Migraine MetaADEDB
Mood Altered MetaADEDB
Mood Swings ADReCS
Mouth Breathing MetaADEDB
Movement Disorder MetaADEDB
Mucocele MetaADEDB
Multiple Sclerosis MetaADEDB
Multiple Sclerosis Relapse MetaADEDB
Muscle Spasms ADReCS
Muscle Tightness MetaADEDB
Muscle Weakness MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Discomfort ADReCS
Myocardial Infarction ADReCS
Myoclonus MetaADEDB
Myxedema MetaADEDB
Nasal Congestion MetaADEDB
Nausea ADReCS
Necrosis MetaADEDB
Negative Thoughts MetaADEDB
Nephrogenic Fibrosing Dermopathy MetaADEDB
Nephrolithiasis MetaADEDB
Nephrotic Syndrome MetaADEDB
Nervousness ADReCS
Neumonia MetaADEDB
Neuropathy Peripheral MetaADEDB
Neutropenic Infection MetaADEDB
Nightmare MetaADEDB
Nodule MetaADEDB
Nodule Skin MetaADEDB
Oedema Mouth MetaADEDB
Oral Discomfort MetaADEDB
Oropharyngeal Pain MetaADEDB
Oropharyngeal Plaque MetaADEDB
Osteoarthritis MetaADEDB
Osteochondroma MetaADEDB
Osteomyelitis MetaADEDB
Pain ADReCS
Pain In Throat MetaADEDB
Palpitation MetaADEDB
Palpitations ADReCS
Paresthesia MetaADEDB
Peau DOrange MetaADEDB
Pharyngolaryngeal Pain MetaADEDB
Platelet Aggregation Increased MetaADEDB
Platelet Aggregation Inhibition MetaADEDB
Pneumonia Staphylococcal MetaADEDB
Pollakiuria MetaADEDB
Post Herpetic Neuralgia MetaADEDB
Post Procedural Infection MetaADEDB
Post Procedural Pain MetaADEDB
Postoperative Wound Infection MetaADEDB
Prostatomegaly MetaADEDB
Pruritus ADReCS
Pruritus Allergic MetaADEDB
Pseudotumor SIDER
Psoriasis MetaADEDB
Psychomotor Hyperactivity ADReCS
Psychosomatic Disease MetaADEDB
Pulmonary Valve Incompetence MetaADEDB
Pulse Pressure Increased ADReCS
Pyrexia ADReCS
Quality Of Life Decreased MetaADEDB
Rales MetaADEDB
Rash ADReCS
Reading Disorder MetaADEDB
Red Blood Cell Schistocytes Present MetaADEDB
Renal Cyst MetaADEDB
Renal Function Test Abnormal MetaADEDB
Renal Impairment MetaADEDB
Renal Insufficiency MetaADEDB
Respiratory Failure MetaADEDB
Retching ADReCS
Retrocollis MetaADEDB
Salivary Gland Inflammation MetaADEDB
Scar MetaADEDB
Scoliosis MetaADEDB
Seizures MetaADEDB
Septic Shock MetaADEDB
Serum Sickness ADReCS
Shock ADReCS
Sickness MetaADEDB
Sinus Operation MetaADEDB
Sinusitis MetaADEDB
Skin Desquamation MetaADEDB
Skin Fibrosis MetaADEDB
Skin Hypertrophy MetaADEDB
Skin Induration MetaADEDB
Skin Tightness MetaADEDB
Slipped Femoral Capital Epiphysis SIDER
Soliloquy MetaADEDB
Spinal Column Stenosis MetaADEDB
Spinal Compression Fracture MetaADEDB
Spinal Disorder MetaADEDB
Spinal Haemangioma MetaADEDB
Sputum Discoloured MetaADEDB
Staphylococcal Bacteraemia MetaADEDB
Staphylococcal Infection MetaADEDB
Stress Symptoms MetaADEDB
Subcutaneous Nodule MetaADEDB
Sweating MetaADEDB
Sweating Increased MetaADEDB
Tachycardia ADReCS
Tachycardia Atrioventricular Nodal Reentry MetaADEDB
Tachycardia Ventricular MetaADEDB
Temperature Intolerance ADReCS
Temperature Regulation Disorder MetaADEDB
Tension ADReCS
Terminal State MetaADEDB
Thyroid Diseases MetaADEDB
Thyroid Operation MetaADEDB
Thyrotoxicosis MetaADEDB
Tinnitus MetaADEDB
Tooth Extraction MetaADEDB
Tremor ADReCS
Troponin Increased MetaADEDB
Tubulointerstitial Nephritis MetaADEDB
Unresponsive To Stimuli MetaADEDB
Upper Airway Obstruction MetaADEDB
Urticaria ADReCS
Uterine Polyp MetaADEDB
Ventricular Fibrillation MetaADEDB
Viral Upper Respiratory Tract Infection MetaADEDB
Vitamin A Deficiency MetaADEDB
Vitreous Detachment MetaADEDB
Vitreous Disorder MetaADEDB
Vomiting ADReCS
Weakness MetaADEDB
Weight Decreased ADReCS
Weight Gain MetaADEDB
Wheezing ADReCS
Withdrawal Syndrome MetaADEDB
Wound Infection MetaADEDB
Wound Infection Bacterial MetaADEDB
X-Ray Dental MetaADEDB

InAADR: Drug-Protein-ADRs database