InAADR

Drug Information

Drug Name: Desipramine (50-47-5)
PubChem ID: 2995
SMILES: CNCCCN1C2=CC=CC=C2CCC3=CC=CC=C31
InchiKey: HCYAFALTSJYZDH-UHFFFAOYSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 266.388
LogP: 3.5328
Ring Count: 2
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 15.27

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Long-Term Changes In Synaptic Function In The Brain Growth factor ARC (Q9WV31) Chronic treatment with antidepressant drugs induces Arc gene expression in specific regions across the rat forebrain@Up-regulation of Arc expression may be part of the process by which antidepressant drugs achieve long-term changes in synaptic function in the brain [ ADR Type 2 ] Antidepressant drug treatment induces Arc gene expression in the rat brain

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Cramp ADReCS
Abdominal Cramp SIDER
Abdominal Discomfort MetaADEDB
Abdominal Distension ADReCS
Abdominal Pain ADReCS
Abnormal Gait MetaADEDB
Accommodation Disorder ADReCS
Aching Joints MetaADEDB
Aching Muscles MetaADEDB
Acute Brain Syndrome MetaADEDB
Acute Coronary Syndrome ADReCS
Addiction SIDER
Adenitis SIDER
Adenocarcinoma MetaADEDB
Adrenal Suppression MetaADEDB
Affective Disorders Psychotic MetaADEDB
Agitation ADReCS
Agranulocytosis ADReCS
Alcohol Withdrawal Syndrome MetaADEDB
Alopecia ADReCS
Amnesia MetaADEDB
Anaemia MetaADEDB
Angiitis MetaADEDB
Angioedema MetaADEDB
Anorexia ADReCS
Anxiety ADReCS
Anxiety Disorders MetaADEDB
Aortic Thrombosis MetaADEDB
Aphasia MetaADEDB
Arrhythmia ADReCS
Arrhythmias Cardiac MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Aseptic Necrosis Bone MetaADEDB
Asthenia ADReCS
Ataxia ADReCS
Atrioventricular Block ADReCS
Attention Deficit Disorder With Hyperactivity MetaADEDB
Back Ache MetaADEDB
Basal Ganglia Diseases MetaADEDB
Biopsy Bone Marrow Abnormal MetaADEDB
Bipolar Disorder MetaADEDB
Black Hairy Tongue SIDER
Bladder Dilatation ADReCS
Bladder Distension ADReCS
Bladder Inflammation MetaADEDB
Bladder Retention MetaADEDB
Blepharoptosis MetaADEDB
Block Heart SIDER
Blood Alkaline Phosphatase Increased ADReCS
Blood Glucose Abnormal ADReCS
Blood Glucose Decreased MetaADEDB
Blood Glucose Fluctuation MetaADEDB
Blood Sodium MetaADEDB
Body Temperature MetaADEDB
Body Temperature Increased ADReCS
Bone Disorder MetaADEDB
Bone Marrow Transplant MetaADEDB
Bradycardia ADReCS
Brain Oedema MetaADEDB
Breast Enlargement ADReCS
Bronchial Spasm MetaADEDB
Bronchospasm ADReCS
Brugada Syndrome MetaADEDB
Bulging MetaADEDB
Bulimia MetaADEDB
Bulimia Nervosa MetaADEDB
Bundle-Branch Block MetaADEDB
Cardiac Arrest ADReCS
Cardiac Decompensation MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Congestive ADReCS
Cardiac Fibrillation ADReCS
Cartilage Development Disorder MetaADEDB
Catalepsy MetaADEDB
Cerebrovascular Accident ADReCS
Cholecystitis MetaADEDB
Cholinergic Crisis SIDER
Cholinergic Syndrome ADReCS
Choreoathetoid Movements SIDER
Choreoathetosis ADReCS
Cocaine-Related Disorders MetaADEDB
Colitis MetaADEDB
Colonic Neoplasms MetaADEDB
Coma ADReCS
Completed Suicide MetaADEDB
Confabulation MetaADEDB
Confusion MetaADEDB
Confusional State ADReCS
Congestive Cardiomyopathy MetaADEDB
Consciousness Disorders MetaADEDB
Constipated MetaADEDB
Constipation ADReCS
Convulsion ADReCS
Coordination Abnormal ADReCS
Cramp Muscle SIDER
Cross Sensitivity Reaction ADReCS
Death ADReCS
Death Sudden MetaADEDB
Debridement MetaADEDB
Decreased Appetite ADReCS
Decreased Libido MetaADEDB
Delirium MetaADEDB
Delusion ADReCS
Demyelination MetaADEDB
Dental Caries MetaADEDB
Dependence ADReCS
Depression ADReCS
Depressive Disorder MetaADEDB
Depressive Disorder Major MetaADEDB
Dermatitis ADReCS
Dermatitis Seborrheic MetaADEDB
Diabetes MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diarrhoea ADReCS
Discomfort ADReCS
Disorientation ADReCS
Distention SIDER
Disturbance In Sexual Arousal ADReCS
Diuresis SIDER
Dizziness ADReCS
Drowsiness SIDER
Drug Dependence ADReCS
Drug Dispensing Error MetaADEDB
Drug Fever ADReCS
Drug Screen Positive MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Mouth ADReCS
Dysgeusia ADReCS
Dyskinesia Drug-Induced MetaADEDB
Dyspepsia ADReCS
Dysphonia MetaADEDB
Dyspnea Exertional MetaADEDB
Dysthymic Disorder MetaADEDB
Effusion MetaADEDB
Ejaculation Disorder ADReCS
Ejection Fraction Decreased MetaADEDB
Electrocardiogram St Segment Elevation MetaADEDB
Electroencephalogram Abnormal ADReCS
Enlarged Spleen MetaADEDB
Eosinophilia ADReCS
Epigastric Distress SIDER
Erectile Dysfunction ADReCS
Eruption MetaADEDB
Excess Potassium MetaADEDB
Extrapyramidal Disorder ADReCS
Extrapyramidal Symptoms SIDER
Extremity Pain MetaADEDB
Face Oedema ADReCS
Face Pain MetaADEDB
Fall ADReCS
Fatigue ADReCS
Feeling Abnormal ADReCS
Flushing ADReCS
Formication MetaADEDB
Galactorrhoea ADReCS
Gastric Hyperplasia MetaADEDB
Gastrointestinal Pain ADReCS
Glycosylated Haemoglobin Increased MetaADEDB
Grand Mal Convulsion ADReCS
Gynaecomastia ADReCS
Haemosiderosis MetaADEDB
Hallucination ADReCS
Headache ADReCS
Heart Block MetaADEDB
Heart Diseases MetaADEDB
Hepatic Function Abnormal ADReCS
Hepatitis ADReCS
Hepatomegaly ADReCS
Hernia MetaADEDB
Hospitalisation MetaADEDB
Hyperacusis ADReCS
Hyperhidrosis ADReCS
Hyperkinesia ADReCS
Hypertension ADReCS
Hypertrophy ADReCS
Hypoaesthesia ADReCS
Hypokinesia MetaADEDB
Hypomania ADReCS
Hypopituitarism MetaADEDB
Hypotension ADReCS
Hypotension Orthostatic MetaADEDB
Hypothermia MetaADEDB
Hypovolaemia MetaADEDB
Idiosyncratic Drug Reaction MetaADEDB
Ileus ADReCS
Ileus Paralytic ADReCS
Ill-Defined Disorder ADReCS
Impotence ADReCS
Impulse-Control Disorder MetaADEDB
Inappropriate Adh Syndrome MetaADEDB
Inappropriate Antidiuretic Hormone Secretion ADReCS
Incoherent MetaADEDB
Infarction ADReCS
Infection Urinary Tract MetaADEDB
Infection Viral MetaADEDB
Infectious Mononucleosis MetaADEDB
Injection Site Pruritus MetaADEDB
Insomnia ADReCS
Intervertebral Disc Disorder MetaADEDB
Intervertebral Disc Operation MetaADEDB
Intoxication SIDER
Intraocular Pressure Increased ADReCS
Jaundice ADReCS
Jaw Operation MetaADEDB
Joint Effusion MetaADEDB
Leucopenia MetaADEDB
Leukopenia MetaADEDB
Libido Decreased ADReCS
Libido Disorder ADReCS
Light Sensitivity MetaADEDB
Lightheadedness SIDER
Liver Function Test Abnormal ADReCS
Localised Oedema MetaADEDB
Long Qt Syndrome MetaADEDB
Loss Of Weight MetaADEDB
Lumbar Vertebral Fracture MetaADEDB
Lymphadenitis ADReCS
Malaise ADReCS
Malignant Syndrome Nos SIDER
Mental Disorders MetaADEDB
Mental Impairment MetaADEDB
Micturition Disorder ADReCS
Middle Ear Inflammation MetaADEDB
Migraine MetaADEDB
Miosis MetaADEDB
Mood Altered MetaADEDB
Mood Disorders MetaADEDB
Multiple Myeloma MetaADEDB
Muscarinic Effects SIDER
Muscle Hypertonia MetaADEDB
Muscle Spasms ADReCS
Muscular Weakness ADReCS
Mydriasis ADReCS
Myocardial Infarction ADReCS
Myocarditis MetaADEDB
Myoclonus ADReCS
Nausea ADReCS
Nerve Degeneration MetaADEDB
Neumonia MetaADEDB
Neuralgia MetaADEDB
Neuroleptic Malignant Syndrome ADReCS
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Nightmare ADReCS
Nocturia ADReCS
Nocturnal Enuresis MetaADEDB
Nodal Arrhythmia ADReCS
Nodal Tachycardia SIDER
Numbness SIDER
Ocular Icterus MetaADEDB
Oedema ADReCS
Opioid-Related Disorders MetaADEDB
Osteomyelitis MetaADEDB
Pain MetaADEDB
Palpitations ADReCS
Pancreatic Enzymes Increased ADReCS
Panic Disorder MetaADEDB
Paraesthesia ADReCS
Parkinson Disease MetaADEDB
Parotid Gland Enlargement ADReCS
Parotid Swelling SIDER
Peripheral Nervous System Diseases MetaADEDB
Peripheral Sensory Neuropathy ADReCS
Personality Disorders MetaADEDB
Petechiae ADReCS
Phosphatase Alkaline Increased SIDER
Photosensitivity Reaction ADReCS
Pigmentation Disorder MetaADEDB
Plasmacytoma MetaADEDB
Platelet Count MetaADEDB
Poisoning ADReCS
Pollakiuria ADReCS
Polyuria ADReCS
Prescribed Overdose MetaADEDB
Pressure Of Speech ADReCS
Product Taste Abnormal ADReCS
Prostatomegaly MetaADEDB
Pruritus ADReCS
Pruritus Generalised MetaADEDB
Psychomotor Skills Impaired MetaADEDB
Psychoses Substance-Induced MetaADEDB
Psychotic Disorder ADReCS
Pulmonary Thrombosis MetaADEDB
Purpura ADReCS
Pyrexia ADReCS
Radicular Pain MetaADEDB
Raised Liver Function Tests SIDER
Rash ADReCS
Rash Generalised MetaADEDB
Restlessness ADReCS
Road Traffic Accident MetaADEDB
Salivary Hypersecretion ADReCS
Salivation SIDER
Seizures SIDER
Sensory Loss ADReCS
Sexual Dysfunctions Psychological MetaADEDB
Shock ADReCS
Sialoadenitis ADReCS
Skin Discolouration MetaADEDB
Skin Plaque MetaADEDB
Sleep Disorders MetaADEDB
Sleep Initiation And Maintenance Disorders MetaADEDB
Sleep Walking MetaADEDB
Somnolence ADReCS
Spinal Column Stenosis MetaADEDB
Spinal Disorder MetaADEDB
Spinal Fracture MetaADEDB
Spinal Osteoarthritis MetaADEDB
Stem Cell Transplant MetaADEDB
Stereotypic Movement Disorder MetaADEDB
Stomatitis ADReCS
Stroke ADReCS
Stuttering MetaADEDB
Substance Withdrawal Syndrome MetaADEDB
Sudden Death ADReCS
Sweating SIDER
Swelling ADReCS
Syncope MetaADEDB
Tachycardia ADReCS
Tachycardia Sinus MetaADEDB
Tachycardia Ventricular MetaADEDB
Taste Peculiar SIDER
Tendon Disorder MetaADEDB
Testicular Diseases MetaADEDB
Testicular Swelling ADReCS
Thrombocytopenia ADReCS
Tic Disorders MetaADEDB
Tingling Sensation SIDER
Tinnitus ADReCS
Tongue Discolouration ADReCS
Tonic-Clonic Seizures SIDER
Tooth Extraction MetaADEDB
Torsades De Pointes MetaADEDB
Tracheobronchitis MetaADEDB
Tremor ADReCS
Urinary Retention ADReCS
Urinary Tract Disorder ADReCS
Urinary Tract Malformation ADReCS
Urine Output Increased ADReCS
Urticaria ADReCS
Vascular Purpura ADReCS
Ventricular Extrasystoles ADReCS
Ventricular Fibrillation ADReCS
Ventricular Tachycardia ADReCS
Vision Blurred ADReCS
Vomiting ADReCS
Weakness SIDER
Weight Abnormal ADReCS
Weight Fluctuation MetaADEDB
Weight Gain MetaADEDB
Weight Increased ADReCS
Wrong Technique In Drug Usage Process MetaADEDB

InAADR: Drug-Protein-ADRs database