InAADR

Drug Information

Drug Name: Pazopanib (444731-52-6)
PubChem ID: 10113978
SMILES: CC1=C(C=C(C=C1)NC2=NC=CC(=N2)N(C)C3=CC4=NN(C(=C4C=C3)C)C)S(=O)(=O)N
InchiKey: CUIHSIWYWATEQL-UHFFFAOYSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 437.529
LogP: 3.13904
Ring Count: 4
Hydrogen Bond Acceptor Count: 8
Hydrogen Bond Donor Count: 2
Total Polar Surface Area: 119.03

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference
Grapefruit Juice Bone Marrow Toxicity Grapefruit-medication interactions: forbidden fruit or avoidable consequences?
Grapefruit Juice Torsade De Pointes Grapefruit-medication interactions: forbidden fruit or avoidable consequences?

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Distension PROTECT
Abdominal Pain ADReCS
Abdominal Pain PROTECT
Abdominal Pain PROTECT
Ageusia PROTECT
Alanine Aminotransferase PROTECT
Alanine Aminotransferase Increased ADReCS
Alkaline Phosphatase Increased ADReCS
Alopecia ADReCS
Amylase Increased PROTECT
Anal Haemorrhage PROTECT
Anorexia ADReCS
Arterial Thrombosis ADReCS
Arthralgia PROTECT
Aspartate Aminotransferase PROTECT
Aspartate Aminotransferase Abnormal ADReCS
Aspartate Aminotransferase Increased ADReCS
Asthenia ADReCS
Blood Albumin Decreased ADReCS
Blood Alkaline Phosphatase Increased ADReCS
Blood Bilirubin Increased ADReCS
Blood Cholesterol Abnormal PROTECT
Blood Creatinine Increased PROTECT
Blood Glucose Decreased ADReCS
Blood Glucose Increased ADReCS
Blood Magnesium Decreased ADReCS
Blood Phosphorus Decreased ADReCS
Blood Potassium Increased ADReCS
Blood Pressure Diastolic Increased PROTECT
Blood Pressure Increased PROTECT
Blood Pressure Systolic Increased PROTECT
Blood Sodium Decreased ADReCS
Blood Thyroid Stimulating Hormone Increased PROTECT
Blood Urea Increased PROTECT
Bradycardia PROTECT
Bronchial Haemorrhage PROTECT
Cardiac Disorder PROTECT
Cardiac Failure ADReCS
Cerebral Haemorrhage PROTECT
Cerebral Infarction PROTECT
Cerebrovascular Accident PROTECT
Cerebrovascular Disorder ADReCS
Chest Pain ADReCS
Chills ADReCS
Cough ADReCS
Decreased Appetite ADReCS
Deep Vein Thrombosis PROTECT
Dehydration PROTECT
Diarrhoea ADReCS
Dizziness ADReCS
Drug Toxicity ADReCS
Drug-Induced Liver Injury PROTECT
Dry Mouth PROTECT
Dry Skin ADReCS
Dysgeusia ADReCS
Dyspepsia ADReCS
Dysphonia ADReCS
Dyspnoea ADReCS
Ear Nose And Throat Examination Abnormal PROTECT
Electrocardiogram Qt Prolonged ADReCS
Embolism ADReCS
Embolism Venous PROTECT
Enterocutaneous Fistula PROTECT
Epistaxis ADReCS
Erythema PROTECT
Exfoliative Rash ADReCS
Eye Oedema PROTECT
Eyelash Discolouration PROTECT
Eyelid Oedema PROTECT
Face Oedema ADReCS
Fatigue ADReCS
Fistula PROTECT
Flatulence PROTECT
Flushing PROTECT
Frequent Bowel Movements PROTECT
Gamma-Glutamyltransferase Increased PROTECT
Gastric Haemorrhage PROTECT
Gastrointestinal Disorder ADReCS
Gastrointestinal Fistula ADReCS
Gastrointestinal Haemorrhage PROTECT
Gastrointestinal Pain ADReCS
Gastrointestinal Perforation PROTECT
Genital Haemorrhage ADReCS
Gingivitis PROTECT
Haematemesis PROTECT
Haematochezia PROTECT
Haematuria ADReCS
Haemolytic Uraemic Syndrome PROTECT
Haemoptysis ADReCS
Haemorrhage ADReCS
Haemorrhage Intracranial ADReCS
Haemorrhage Urinary Tract PROTECT
Haemorrhoidal Haemorrhage PROTECT
Hair Colour Changes ADReCS
Headache ADReCS
Hepatic Enzyme Increased PROTECT
Hepatic Failure PROTECT
Hepatic Function Abnormal PROTECT
Hepatotoxicity ADReCS
Hiccups PROTECT
Hot Flush PROTECT
Hyperalbuminaemia PROTECT
Hyperbilirubinaemia PROTECT
Hyperhidrosis PROTECT
Hypertension ADReCS
Hypertensive Crisis PROTECT
Hypoaesthesia PROTECT
Hypogeusia PROTECT
Hypomagnesaemia PROTECT
Hypophosphataemia PROTECT
Hypothyroidism ADReCS
Ileal Perforation PROTECT
Infection ADReCS
Insomnia ADReCS
Intestinal Perforation PROTECT
Ischaemic Stroke PROTECT
Jaundice PROTECT
Large Intestine Perforation PROTECT
Left Ventricular Dysfunction ADReCS
Lethargy PROTECT
Leukopenia ADReCS
Lipase Increased ADReCS
Liver Function Test Abnormal PROTECT
Localised Oedema PROTECT
Lung Disorder ADReCS
Lymphopenia ADReCS
Melaena PROTECT
Menorrhagia PROTECT
Metrorrhagia PROTECT
Mouth Haemorrhage PROTECT
Mouth Ulceration PROTECT
Mucosal Inflammation ADReCS
Mucous Membrane Disorder PROTECT
Muscle Spasms PROTECT
Musculoskeletal Pain ADReCS
Myalgia ADReCS
Myocardial Infarction ADReCS
Myocardial Ischaemia ADReCS
Nail Disorder ADReCS
Nausea ADReCS
Neutropenia ADReCS
Neutrophil Count Decreased PROTECT
Oedema ADReCS
Oedema Peripheral ADReCS
Oesophageal Haemorrhage PROTECT
Oropharyngeal Pain PROTECT
Palmar-Plantar Erythrodysaesthesia Syndrome ADReCS
Pancreatitis PROTECT
Paraesthesia PROTECT
Peripheral Sensory Neuropathy PROTECT
Peritonitis PROTECT
Photosensitivity Reaction PROTECT
Plantar Erythema PROTECT
Platelet Count Decreased PROTECT
Pneumothorax PROTECT
Posterior Reversible Encephalopathy Syndrome PROTECT
Proteinuria ADReCS
Pruritus PROTECT
Pruritus Generalised PROTECT
Pulmonary Embolism PROTECT
Pulmonary Haemorrhage PROTECT
Rash ADReCS
Rash Erythematous PROTECT
Rash Generalised PROTECT
Rash Macular PROTECT
Rash Papular PROTECT
Rash Pruritic PROTECT
Rash Vesicular PROTECT
Rectal Haemorrhage ADReCS
Restrictive Cardiomyopathy PROTECT
Retroperitoneal Haemorrhage PROTECT
Reversible Posterior Leukoencephalopathy Syndrome ADReCS
Rhinorrhoea PROTECT
Skin Depigmentation ADReCS
Skin Disorder ADReCS
Skin Exfoliation PROTECT
Skin Hypopigmentation ADReCS
Skin Ulcer PROTECT
Somnolence PROTECT
Stomatitis ADReCS
Thrombocytopenia ADReCS
Thrombosis PROTECT
Thrombotic Microangiopathy PROTECT
Thrombotic Thrombocytopenic Purpura PROTECT
Thyroid Function Test Abnormal PROTECT
Torsade De Pointes ADReCS
Transaminases Increased PROTECT
Transient Ischaemic Attack ADReCS
Tumour Pain ADReCS
Upper Gastrointestinal Haemorrhage PROTECT
Vaginal Haemorrhage PROTECT
Vision Blurred ADReCS
Vomiting ADReCS
Weight Decreased ADReCS
White Blood Cell Count Decreased PROTECT

InAADR: Drug-Protein-ADRs database