InAADR

Drug Information

Drug Name: Mexiletine (31828-71-4)
PubChem ID: 4178
SMILES: CC1=C(C(=CC=C1)C)OCC(C)N
InchiKey: VLPIATFUUWWMKC-UHFFFAOYSA-N
Therapeutic Category: Anti-Arrhythmia Agents, Cardiovascular Agents, Membrane Transport Modulators, Sodium Channel Blockers, Voltage-Gated Sodium Channel Blockers

Computed Drug Properties

Molecular Weight (dalton): 179.263
LogP: 2.02944
Ring Count: 1
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 1
Total Polar Surface Area: 35.25

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference
Morphine (57-27-2) Myocardial Infarction Antagonistic Uncertain A trial of intravenous and oral mexiletine in acute myocardial infarction

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Increasing Mexiletine Toxicity CYP2D6 (P10635) Fluoxetine competitively inhibits CYP2D6 activity@thus reduces mexiletine clearnace and increases mexiletine toxicity [ ADR Type 4 ] Comment: potential risk of valproic acid therapy in patients who are HIV-positive
Proarrhythmia CYP2D6 (P10635) Proarrhythmic and other toxic effects [ ADR Type 2 ] Drugs in special patient groups: clinical importance of genomics in drug effects In: Carruthers GS, Hoffmann BB,Melmon KL, Nierenberg DW
Sudden Cardiac Death Potassium voltage-gated channel subfamily E member 1 (P15382) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death Potassium voltage-gated channel subfamily H member 2 (Q12809) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death Potassium voltage-gated channel subfamily KQT member 1 (P51787) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II
Sudden Cardiac Death Sodium channel protein type 5 subunit alpha (Q14524) Sudden cardiac death due to long-QT syndrome [ ADR Type 2 ] Genetic and molecular basis of cardiac arrhythmias: impact on clinical management parts I and II

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Cramp ADReCS
Abdominal Discomfort ADReCS
Abdominal Distension MetaADEDB
Abdominal Pain ADReCS
Abnormal Behaviour MetaADEDB
Abnormal Faeces MetaADEDB
Abnormal Sleep-Related Event ADReCS
Abscess Limb MetaADEDB
Accelerated Idioventricular Rhythm MetaADEDB
Acute Hepatic Failure MetaADEDB
Acute Promyelocytic Leukaemia MetaADEDB
Acute Yellow Liver Atrophy SIDER
Adenopathy MetaADEDB
Administration Site Pain MetaADEDB
Adynamic Ileus MetaADEDB
Ageusia MetaADEDB
Agranulocytoses MetaADEDB
Agranulocytosis ADReCS
Alanine Aminotransferase Increased MetaADEDB
Albumin Urine Present MetaADEDB
Alcohol Consumption MetaADEDB
Alcohol Interaction MetaADEDB
Alcohol Poisoning MetaADEDB
Allergies MetaADEDB
Alopecia ADReCS
Altered State Of Consciousness MetaADEDB
Amentia MetaADEDB
Amnesia ADReCS
Anaemia MetaADEDB
Anaesthesia MetaADEDB
Angina MetaADEDB
Angina Pectoris ADReCS
Anorexia MetaADEDB
Antibody Test MetaADEDB
Antinuclear Antibody Positive ADReCS
Appetite Disorder ADReCS
Arrhythmia Supraventricular ADReCS
Arrhythmias Cardiac MetaADEDB
Arteriosclerosis MetaADEDB
Arteriovenous Fistula MetaADEDB
Arthralgia ADReCS
Arthrodesis MetaADEDB
Ascites MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Aspiration Pneumonia MetaADEDB
Asthenia ADReCS
Asystole MetaADEDB
Ataxia ADReCS
Atrial Arrhythmia SIDER
Atrial Ectopic Beats MetaADEDB
Atrioventricular Block ADReCS
Atrioventricular Conduction Time Shortened ADReCS
Axillary Pain MetaADEDB
Bacterial Toxaemia MetaADEDB
Basedow Disease MetaADEDB
Bladder Cancer MetaADEDB
Bleeding Hemorrhoids MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Chloride Decreased MetaADEDB
Blood Cholinesterase Decreased MetaADEDB
Blood Creatine Phosphokinase Increased MetaADEDB
Blood Disorder MetaADEDB
Blood Dyscrasia ADReCS
Blood Glucose Decreased MetaADEDB
Blood Immunoglobulin E MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Phosphorus Increased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Pressure Diastolic Decreased MetaADEDB
Blood Pressure Inadequately Controlled MetaADEDB
Blood Urea Increased MetaADEDB
Blood Uric Acid MetaADEDB
Body Temperature Increased ADReCS
Bradycardia ADReCS
Brain Natriuretic Peptide Increased MetaADEDB
Breast Cancer Male MetaADEDB
Breast Cellulitis MetaADEDB
Breast Discomfort MetaADEDB
Breast Pain MetaADEDB
Bundle Branch Block Left MetaADEDB
Burning Sensation Mucosal MetaADEDB
C-Reactive Protein Increased MetaADEDB
Cancer Pain MetaADEDB
Carcinoid Syndrome MetaADEDB
Cardiac Ablation MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Failure ADReCS
Cardiac Failure Chronic MetaADEDB
Cardiac Failure Congestive ADReCS
Cardiac Hypertrophy MetaADEDB
Cardiac Valve Disease MetaADEDB
Cardio-Respiratory Arrest MetaADEDB
Cardioactive Drug Level MetaADEDB
Cardioactive Drug Level Increased MetaADEDB
Cardiogenic Shock ADReCS
Cardiomyopathy MetaADEDB
Carotid Artery Stenosis MetaADEDB
Cartilage Development Disorder MetaADEDB
Cell Marker Increased MetaADEDB
Central Nervous System Diseases MetaADEDB
Cerebral Disorder MetaADEDB
Cerebral Infarct MetaADEDB
Cerebral Thrombosis MetaADEDB
Cervicobrachial Syndrome MetaADEDB
Chemotherapeutic Drug Level Increased MetaADEDB
Chest Pain ADReCS
Chest X-Ray Abnormal MetaADEDB
Choking Sensation MetaADEDB
Chronic Kidney Disease MetaADEDB
Clavicle Fracture MetaADEDB
Condition Aggravated MetaADEDB
Confusional State ADReCS
Congenital Mitral Valve Incompetence MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Congestive Cardiomyopathy MetaADEDB
Constipation ADReCS
Conversion Disorder MetaADEDB
Convulsion ADReCS
Coordination Abnormal ADReCS
Coronary Artery Restenosis MetaADEDB
Coronary Artery Stenosis MetaADEDB
Crackles Lung MetaADEDB
Cramp Muscle SIDER
Csf Monocyte Count Increased MetaADEDB
Csf Neutrophil Count Increased MetaADEDB
Cutaneous Ulcer MetaADEDB
Cytomegalovirus Colitis MetaADEDB
Cytomegalovirus Enterocolitis MetaADEDB
Decubitus Ulcer MetaADEDB
Delusion MetaADEDB
Dental Pain MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Dermatitis Exfoliative ADReCS
Device Malfunction MetaADEDB
Diabetes Mellitus Insulin-Dependent MetaADEDB
Diabetic Autonomic Neuropathy MetaADEDB
Diabetic Retinopathy MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Diplopia MetaADEDB
Discomfort ADReCS
Disease Of Liver MetaADEDB
Disease Recurrence MetaADEDB
Disorder Lung MetaADEDB
Disorder Renal MetaADEDB
Disseminated Intravascular Coagulation MetaADEDB
Distress Gastrointestinal SIDER
Disturbance In Sexual Arousal ADReCS
Diverticulitis Intestinal Haemorrhagic MetaADEDB
Diverticulum Intestinal Haemorrhagic MetaADEDB
Dizziness ADReCS
Dizziness Exertional MetaADEDB
Drowsiness SIDER
Drug Eruptions MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug Toxicity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Dry Mouth ADReCS
Dry Skin ADReCS
Dysgeusia ADReCS
Dysgraphia MetaADEDB
Dyslipidaemia MetaADEDB
Dyspepsia ADReCS
Dysphagia ADReCS
Dysphoria MetaADEDB
Dyspnea Exertional MetaADEDB
Dyspnoea ADReCS
Dysstasia MetaADEDB
Economic Problem MetaADEDB
Eczema MetaADEDB
Ejection Fraction Decreased MetaADEDB
Electrocardiogram Qt Corrected Interval Prolonged MetaADEDB
Electrocardiogram Qt Prolonged MetaADEDB
Electrocardiogram T Wave Inversion MetaADEDB
Encephalitis Allergic MetaADEDB
Encephalitis Herpes MetaADEDB
Enterobacter Infection MetaADEDB
Eosinophil Count Increased MetaADEDB
Eosinophilia MetaADEDB
Erectile Dysfunction ADReCS
Eruption MetaADEDB
Erythema MetaADEDB
Erythromelalgia MetaADEDB
Extensor Plantar Response MetaADEDB
Extrasystoles MetaADEDB
Extrasystoles Ventricular MetaADEDB
Fatigue ADReCS
Feeding Tube Insertion MetaADEDB
Feeling Abnormal ADReCS
Fever MetaADEDB
Fibrin Degradation Products Increased MetaADEDB
Fibrosis ADReCS
Fungal Disease MetaADEDB
Gamma-Glutamyltransferase Increased MetaADEDB
Gastric Ulcer MetaADEDB
Gastrointestinal Diseases MetaADEDB
Gastrointestinal Haemorrhage ADReCS
Gastrointestinal Pain ADReCS
Gastrointestinal Stromal Tumour MetaADEDB
Gaze Palsy MetaADEDB
General Physical Health Deterioration MetaADEDB
Generalised Erythema MetaADEDB
Glossitis MetaADEDB
Glucose Urine MetaADEDB
Glycosylated Haemoglobin Increased MetaADEDB
Granulocytosis MetaADEDB
Gynaecomastia MetaADEDB
Haemodialysis MetaADEDB
Haemoglobin ADReCS
Haemolytic Anaemia MetaADEDB
Haemorrhage ADReCS
Haemorrhagic Hepatic Cyst MetaADEDB
Hallucination ADReCS
Headache ADReCS
Heart Failure MetaADEDB
Heart Injury MetaADEDB
Heartburn ADReCS
Helicobacter Pylori Identification Test Positive MetaADEDB
Hepatic Function Abnormal ADReCS
Hepatic Lesion MetaADEDB
Hepatic Necrosis ADReCS
Hepatitis ADReCS
Hepatitis Fulminant MetaADEDB
Herpes Zoster MetaADEDB
Hiccups ADReCS
Hot Flush ADReCS
Human Herpes Virus 6 Serology Positive MetaADEDB
Human Herpesvirus 6 Infection MetaADEDB
Hyperalgesia MetaADEDB
Hypercapnia MetaADEDB
Hyperhidrosis ADReCS
Hyperkinesis MetaADEDB
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertrophic Cardiomyopathy MetaADEDB
Hyperventilation MetaADEDB
Hypoaesthesia ADReCS
Hypoglobulinaemia MetaADEDB
Hypotension ADReCS
Ichthyosis MetaADEDB
Idiopathic Thrombocytopenic Purpura MetaADEDB
Ild MetaADEDB
Ileal Stenosis MetaADEDB
Ill-Defined Disorder ADReCS
Immune System Disorder MetaADEDB
Inadequate Diet MetaADEDB
Increased White Blood Cell Count MetaADEDB
Influenza Like Illness MetaADEDB
Injury Asphyxiation MetaADEDB
Intestinal Haemorrhage MetaADEDB
Ischaemic Cardiomyopathy MetaADEDB
Kidney Failure MetaADEDB
Klebsiella Infection MetaADEDB
Large Intestinal Ulcer MetaADEDB
Laryngeal Disorder ADReCS
Leucopenia MetaADEDB
Leukopenia ADReCS
Leukopenia Neonatal MetaADEDB
Leukoplakia Of Mouth MetaADEDB
Libido Decreased ADReCS
Lightheadedness SIDER
Lip Erosion MetaADEDB
Lipase MetaADEDB
Liver Function Test Abnormal ADReCS
Long Qt Syndrome MetaADEDB
Loss Of Consciousness ADReCS
Lung Adenocarcinoma MetaADEDB
Lung Cancer Metastatic MetaADEDB
Lung Infiltration ADReCS
Lung Neoplasm Malignant MetaADEDB
Lyell MetaADEDB
Lymph Node Palpable MetaADEDB
Lymphocyte Count Decreased MetaADEDB
Lymphocyte Morphology Abnormal MetaADEDB
Lymphocyte Stimulation Test Positive MetaADEDB
Lymphocytosis MetaADEDB
Malaise ADReCS
Malignant Neoplasm Progression MetaADEDB
Malnourished MetaADEDB
Markedly Reduced Dietary Intake MetaADEDB
Memory Loss SIDER
Meningitis Viral MetaADEDB
Menopausal Symptoms ADReCS
Mental Disorder ADReCS
Mesenteric Vascular Insufficiency MetaADEDB
Metastases To Liver MetaADEDB
Mouth Bleeding MetaADEDB
Mucocutaneous Rash MetaADEDB
Mucosal Erosion MetaADEDB
Mucous Membrane Disorder ADReCS
Multiple Injuries MetaADEDB
Multiple Sclerosis Relapse MetaADEDB
Muscle Spasms ADReCS
Muscle Weakness MetaADEDB
Muscular Weakness ADReCS
Musculoskeletal Discomfort ADReCS
Mycobacterium Tuberculosis Infection MetaADEDB
Myelitis MetaADEDB
Myelodysplasia MetaADEDB
Myelofibrosis ADReCS
Myeloid Metaplasia ADReCS
Myoclonic Epilepsy MetaADEDB
Myoclonus MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Necrosis ADReCS
Nervousness ADReCS
Neumonia MetaADEDB
Neuralgia MetaADEDB
Neutropenia ADReCS
No Reaction On Previous Exposure To Drug MetaADEDB
Non-Small Cell Lung Cancer MetaADEDB
Numbness SIDER
Nystagmus ADReCS
Oculomucocutaneous Syndrome MetaADEDB
Oedema ADReCS
Oesophageal Disorder ADReCS
Oesophageal Ulcer ADReCS
Opportunistic Infection MetaADEDB
Optic Neuritis MetaADEDB
Organising Pneumonia MetaADEDB
Orthopnea MetaADEDB
Osteochondrodysplasias MetaADEDB
Pain ADReCS
Palmar-Plantar Erythrodysaesthesia Syndrome MetaADEDB
Palpitations ADReCS
Pancreatitis ADReCS
Paraesthesia ADReCS
Paraesthesia Oral MetaADEDB
Pemphigus MetaADEDB
Peptic Ulcer ADReCS
Periodontitis MetaADEDB
Peritoneal Dialysis MetaADEDB
Pharyngeal Disorder ADReCS
Pharyngitis ADReCS
Physical Disability MetaADEDB
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Pneumatosis Cystoides Intestinalis MetaADEDB
Pneumocystis Carinii Pneumonia MetaADEDB
Pneumonia Cytomegaloviral MetaADEDB
Poor Peripheral Circulation MetaADEDB
Post Procedural Pain MetaADEDB
Protein Total Decreased MetaADEDB
Prothrombin Level Decreased MetaADEDB
Prothrombin Time MetaADEDB
Pruritus MetaADEDB
Psychiatric Symptom MetaADEDB
Psychomotor Agitation MetaADEDB
Psychotic Disorder ADReCS
Pulmonary Alveolar Haemorrhage MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Artery Dilatation MetaADEDB
Pulmonary Congestion MetaADEDB
Pulmonary Fibrosis ADReCS
Pulmonary Toxicity ADReCS
Pyelectasia MetaADEDB
Pyelonephritis MetaADEDB
Pyrexia ADReCS
Rash ADReCS
Rash Generalised MetaADEDB
Renal Impairment MetaADEDB
Respiratory Disorder MetaADEDB
Respiratory Failure MetaADEDB
Retinal Bleeding MetaADEDB
Retinal Tear MetaADEDB
Salivary Gland Disorder ADReCS
Sclc MetaADEDB
Seizures SIDER
Sensorium Decreased ADReCS
Sensory Loss ADReCS
Shock ADReCS
Shock Haemorrhagic MetaADEDB
Signs And Symptoms Digestive MetaADEDB
Skin Desquamation MetaADEDB
Skin Erosion MetaADEDB
Skin Test Positive MetaADEDB
Sleep Apnea MetaADEDB
Sleep Initiation And Maintenance Disorders MetaADEDB
Small Intestinal Obstruction MetaADEDB
Snoring MetaADEDB
Soliloquy MetaADEDB
Somnolence ADReCS
Speech Disorder ADReCS
Speech Impairment Nos SIDER
Spinal Column Stenosis MetaADEDB
Sputum Culture Positive MetaADEDB
Sputum Retention MetaADEDB
Staring MetaADEDB
Stevens-Johnson Syndrome ADReCS
Subdural Haemorrhage MetaADEDB
Sudden Death MetaADEDB
Sweating Increased SIDER
Syncope ADReCS
Syphilis MetaADEDB
Systemic Lupus Erythematosus ADReCS
Tachycardia MetaADEDB
Tachycardia Ventricular MetaADEDB
Taste Altered SIDER
Tension ADReCS
Therapy Non-Responder MetaADEDB
Thrombocytopenia ADReCS
Thrombophlebitis MetaADEDB
Thrombotic Stroke MetaADEDB
Tinnitus ADReCS
Toe Operation MetaADEDB
Torsades De Pointes MetaADEDB
Toxic Encephalopathy MetaADEDB
Tremor ADReCS
Trismus MetaADEDB
Tumour Lysis Syndrome MetaADEDB
Ulcer ADReCS
Unresponsive To Stimuli MetaADEDB
Upper Gastrointestinal Bleeding MetaADEDB
Upper Gastrointestinal Haemorrhage SIDER
Urinary Hesitation ADReCS
Urinary Retention ADReCS
Urinary Sediment Abnormal MetaADEDB
Venous Pressure Jugular Increased MetaADEDB
Ventricular Arrhythmia ADReCS
Ventricular Dysfunction Left MetaADEDB
Ventricular Fibrillation MetaADEDB
Ventricular Flutter MetaADEDB
Ventricular Premature Complexes MetaADEDB
Virus Serology Test Positive MetaADEDB
Vision Blurred ADReCS
Vision Disorders MetaADEDB
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vith Nerve Disorder MetaADEDB
Vitreous Detachment MetaADEDB
Vitreous Haemorrhage MetaADEDB
Vomiting ADReCS
Waist Circumference Increased MetaADEDB
Weakness SIDER
Wound Infection MetaADEDB

InAADR: Drug-Protein-ADRs database