| Drug Name: | Tramadol (27203-92-5) |
|---|---|
| PubChem ID: | 33741 |
| SMILES: | CN(C)C[C@H]1CCCC[C@@]1(C2=CC(=CC=C2)OC)O |
| InchiKey: | TVYLLZQTGLZFBW-ZBFHGGJFSA-N |
| Therapeutic Category: | Analgesics, Central Nervous System Agents, Central Nervous System Depressants, Narcotics, Peripheral Nervous System Agents, Sensory System Agents |
| Molecular Weight (dalton) | : | 263.381 |
| LogP | : | 2.6346 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 32.7 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Clomipramine (303-49-1) | Serotonin Syndrome | Antagonistic | Not Understood | Seizures reported with tramadol |
| Pseudoephedrine (90-82-4) | Ischaemic Colitis | Antagonistic | Not Clear | Probable ischemic colitis caused by pseudoephedrine with tramadol as a possible contributing factor |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Dry Mouth | Angiotensin-converting enzyme precursor (P12821) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
| Seizures | CYP2D6 (P10635) | Doxepin competitively inhibits CYP2D6 activity@thus it increases the level of tramadol in blood and increases the risk of seizures [ ADR Type 4 ] | Identification of tramadol and its metabolites in blood from drug-related deaths and drug-impaired drivers |
| Vision Blurred | Type-1 angiotensin II receptor (P30556) | Not Available | Large-scale prediction and testing of drug activity on side-effect targets |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category