InAADR

Drug Information

Drug Name: Temsirolimus (162635-04-3)
PubChem ID: 122362113
SMILES: C[C@@H]1CC[C@H]2C[C@@H](C(=CC=C/C=C[C@H](C[C@H](C(=O)[C@@H]([C@@H](/C(=C[C@H](C(=O)C[C@H](OC(=O)[C@@H]3CCCCN3C(=O)C(=O)[C@@]1(O2)O)[C@H](C)C[C@@H]4CC[C@H]([C@@H](C4)OC)OC(=O)C(C)(CO)CO)C)/C)O)OC)C)C)C)OC
InchiKey: CBPNZQVSJQDFBE-YTZPCQKPSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 1030.3
LogP: 5.7224
Ring Count: 0
Hydrogen Bond Acceptor Count: 16
Hydrogen Bond Donor Count: 4
Total Polar Surface Area: 241.96

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Adhesions MetaADEDB
Abdominal Distension ADReCS
Abdominal Pain ADReCS
Abnormal Movements MetaADEDB
Abnormal Vision MetaADEDB
Abscess ADReCS
Acetonaemia MetaADEDB
Acne ADReCS
Activities Of Daily Living Impaired MetaADEDB
Acute Respiratory Failure MetaADEDB
Adrenal Gland Cancer Metastatic MetaADEDB
Adrenal Neoplasm MetaADEDB
Adynamic Ileus MetaADEDB
Ageusia ADReCS
Alanine Aminotransferase MetaADEDB
Alanine Aminotransferase Increased SIDER
Albumin Low SIDER
Allergic Reaction ADReCS
Allergies MetaADEDB
Anaemia ADReCS
Anal Abscess MetaADEDB
Anal Candidiasis PROTECT
Anal Fissure MetaADEDB
Anal Fistula MetaADEDB
Anal Haemorrhage PROTECT
Anaphylactic Reaction PROTECT
Anger MetaADEDB
Angina MetaADEDB
Angina Unstable MetaADEDB
Angioedema ADReCS
Anhedonia MetaADEDB
Anorexia ADReCS
Anuria MetaADEDB
Anxiety PROTECT
Aortic Aneurysm SIDER
Aortic Calcification MetaADEDB
Aortic Dissection SIDER
Aphthous Stomatitis ADReCS
Arthralgia ADReCS
Aspartate Aminotransferase Abnormal ADReCS
Aspartate Aminotransferase Increased ADReCS
Aspiration Pleural Cavity MetaADEDB
Asthenia ADReCS
Asthmatic Crisis MetaADEDB
Asystole MetaADEDB
Ataxia MetaADEDB
Atrial Thrombosis MetaADEDB
Atrophy MetaADEDB
Back Pain ADReCS
Bacteraemia MetaADEDB
Bacterial Infection PROTECT
Bacterial Test Positive MetaADEDB
Bacterial Toxaemia MetaADEDB
Base Excess Decreased MetaADEDB
Bladder Pain ADReCS
Bladder Spasm MetaADEDB
Blood Albumin Decreased ADReCS
Blood Alkaline Phosphatase Increased ADReCS
Blood Bilirubin Increased ADReCS
Blood Cholesterol Abnormal MetaADEDB
Blood Cholesterol Increased ADReCS
Blood Creatine Phosphokinase Mb Increased MetaADEDB
Blood Creatinine Increased ADReCS
Blood Glucose Increased ADReCS
Blood In Urine MetaADEDB
Blood Magnesium Decreased MetaADEDB
Blood Phosphorus Decreased ADReCS
Blood Potassium Decreased ADReCS
Blood Potassium Increased ADReCS
Blood Sodium MetaADEDB
Blood Testosterone Decreased MetaADEDB
Blood Triglycerides MetaADEDB
Blood Triglycerides Increased ADReCS
Body Temperature Increased ADReCS
Bone Cancer Metastatic MetaADEDB
Bone Density Decreased MetaADEDB
Brain Death MetaADEDB
Brain Herniation MetaADEDB
Bronchitis ADReCS
Bulbar Palsy MetaADEDB
Ca++ Increased SIDER
Calcium Low SIDER
Candida Infection PROTECT
Carbon Monoxide Diffusing Capacity Decreased MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Disorder ADReCS
Cardiac Enlargement MetaADEDB
Cardiac Function Test Abnormal MetaADEDB
Cardiac Tamponade MetaADEDB
Cardio-Respiratory Arrest MetaADEDB
Cardiotoxicity MetaADEDB
Cataract PROTECT
Cellulitis ADReCS
Central Nervous System Lesion MetaADEDB
Cerebral Ischaemia MetaADEDB
Cerebrospinal Fistula MetaADEDB
Cervicobrachial Syndrome ADReCS
Chest Pain ADReCS
Chills ADReCS
Cholecystitis MetaADEDB
Cholecystitis Acute MetaADEDB
Colitis MetaADEDB
Colitis Erosive MetaADEDB
Complex Regional Pain Syndrome ADReCS
Computerised Tomogram MetaADEDB
Condition Aggravated MetaADEDB
Conjunctivitis ADReCS
Connective Tissue Disorder SIDER
Constipation ADReCS
Convulsion ADReCS
Convulsions Grand Mal MetaADEDB
Cough ADReCS
Creatinine Increased SIDER
Csf Protein MetaADEDB
Cutaneous Ulcer MetaADEDB
Cyanosis MetaADEDB
Cyst MetaADEDB
Cystitis ADReCS
Cystitis Noninfective ADReCS
Death ADReCS
Decreased Appetite ADReCS
Deep Vein Thromboses MetaADEDB
Deep Vein Thrombosis ADReCS
Deglutition Disorder MetaADEDB
Dehydration PROTECT
Depression ADReCS
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Dermatitis Exfoliative ADReCS
Diabetes MetaADEDB
Diabetes Mellitus PROTECT
Diabetes Mellitus Insulin-Dependent MetaADEDB
Diarrhoea ADReCS
Disease Progression MetaADEDB
Disorder Lung MetaADEDB
Dizziness PROTECT
Drug Hypersensitivity PROTECT
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Skin ADReCS
Duodenal Perforation PROTECT
Dysgeusia ADReCS
Dysphagia PROTECT
Dyspnoea ADReCS
Dysuria ADReCS
Early Satiety MetaADEDB
Ecchymosis PROTECT
Eczema ADReCS
Effusion ADReCS
Electrocardiogram St-T Change MetaADEDB
Elevated Erythrocyte Sedimentation Rate MetaADEDB
Embolism ADReCS
Embolism Pulmonary MetaADEDB
Embolism Venous ADReCS
Embolus SIDER
Empyema MetaADEDB
Enterococcal Sepsis MetaADEDB
Epistaxis ADReCS
Erythema ADReCS
Erythema Migrans MetaADEDB
Escherichia Sepsis MetaADEDB
Escherichia Urinary Tract Infection MetaADEDB
Exfoliative Rash PROTECT
Extravasation ADReCS
Eye Disorder SIDER
Eye Haemorrhage PROTECT
Face Oedema ADReCS
Face Pain MetaADEDB
Fatigue PROTECT
Febrile Neutropenia PROTECT
Folliculitis ADReCS
Fungal Infection PROTECT
Fungal Skin Infection PROTECT
Fungal Test Positive MetaADEDB
Furuncle MetaADEDB
Gastric Hyperplasia MetaADEDB
Gastric Ulcer Haemorrhage MetaADEDB
Gastritis PROTECT
Gastrointestinal Disorder SIDER
Gastrointestinal Haemorrhage PROTECT
Gastrointestinal Pain ADReCS
General Physical Condition MetaADEDB
Generalised Oedema PROTECT
Gingival Bleeding PROTECT
Gingivitis ADReCS
Globulinuria MetaADEDB
Glomerular Filtration Rate Decreased MetaADEDB
Glossitis ADReCS
Glucose Increased SIDER
Glucose Tolerance Impaired ADReCS
Granulocytosis MetaADEDB
Haematoma Infection MetaADEDB
Haematuria ADReCS
Haemodynamic Instability MetaADEDB
Haemoglobin Decreased ADReCS
Haemorrhage Intracranial PROTECT
Haemorrhage Rectum MetaADEDB
Haemorrhoidal Haemorrhage PROTECT
Haemorrhoids MetaADEDB
Headache ADReCS
Hepatitis B MetaADEDB
Herpes Nos SIDER
Herpes Simplex ADReCS
Herpes Simplex Serology Positive MetaADEDB
Herpes Virus Infection ADReCS
Herpes Zoster ADReCS
Hypercalcaemia ADReCS
Hypercapnia MetaADEDB
Hypercholesterolaemia ADReCS
Hyperglycaemia ADReCS
Hyperlipaemia MetaADEDB
Hyperlipidaemia ADReCS
Hypersensitivity ADReCS
Hypertension ADReCS
Hypertriglyceridaemia ADReCS
Hypoalbuminaemia MetaADEDB
Hypocalcaemia ADReCS
Hypokalaemia PROTECT
Hypomagnesaemia MetaADEDB
Hypophosphataemia ADReCS
Hypoxia MetaADEDB
Ild MetaADEDB
Immunosuppression MetaADEDB
Impaired Healing ADReCS
Infection ADReCS
Infection Upper Respiratory MetaADEDB
Infestation SIDER
Infestation Nos SIDER
Inflammation ADReCS
Influenza PROTECT
Infusion Related Reaction MetaADEDB
Insomnia ADReCS
Inspiratory Capacity Decreased MetaADEDB
International Normalised Ratio Increased MetaADEDB
Interstitial Lung Disease ADReCS
Interstitial Pneumonia SIDER
Intervertebral Disc Disorder MetaADEDB
Intestinal Perforation ADReCS
Intestinal Ulcer Perforation MetaADEDB
Intracranial Tumour Haemorrhage MetaADEDB
Kidney Failure MetaADEDB
Klebsiella Infection MetaADEDB
Lacrimal Disorder ADReCS
Lacrimation SIDER
Lacrimation Increased ADReCS
Laryngeal Haemorrhage MetaADEDB
Laryngitis PROTECT
Left Atrial Dilatation MetaADEDB
Left Ventricular Dysfunction MetaADEDB
Leucopenia MetaADEDB
Leukopenia ADReCS
Lip Haemorrhage PROTECT
Liver Abscess MetaADEDB
Loose Tooth MetaADEDB
Loss Of Proprioception MetaADEDB
Lung Abscess MetaADEDB
Lung Disorder ADReCS
Lymphadenopathy Mediastinal MetaADEDB
Lymphocyte Count Decreased ADReCS
Lymphopenia ADReCS
Mastication Disorder MetaADEDB
Mediastinal Disorder SIDER
Meningitides MetaADEDB
Metastases To Central Nervous System MetaADEDB
Metastases To Gastrointestinal Tract MetaADEDB
Metastases To Liver MetaADEDB
Metastases To Spine MetaADEDB
Metastases To The Mediastinum MetaADEDB
Mouth Haemorrhage PROTECT
Mouth Pain MetaADEDB
Mouth Ulcer MetaADEDB
Mouth Ulceration ADReCS
Mucosal Inflammation ADReCS
Multi-Organ Failure MetaADEDB
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort ADReCS
Myalgia ADReCS
Myoclonic Epilepsy MetaADEDB
Nail Disorder ADReCS
Nausea ADReCS
Nephrectomy MetaADEDB
Nephrotic Syndrome MetaADEDB
Nervous System Disorder SIDER
Neumonia MetaADEDB
Neuropathy Peripheral MetaADEDB
Neutropenia ADReCS
Neutrophil Count Decreased ADReCS
Non-Small Cell Lung Cancer MetaADEDB
Oedema ADReCS
Oedema Genital PROTECT
Oedema Peripheral ADReCS
Ophthalmic Herpes Zoster PROTECT
Oral Candidiasis PROTECT
Oral Herpes PROTECT
Oral Pain ADReCS
Osteomyelitis MetaADEDB
Ovarian Cancer Recurrent MetaADEDB
Pain ADReCS
Pancreatitis MetaADEDB
Paraesthesia PROTECT
Paraneoplastic Cerebellar Degeneration MetaADEDB
Paresis Cranial Nerve MetaADEDB
Pericardial Effusion ADReCS
Perineal Fistula MetaADEDB
Periostitis MetaADEDB
Peripheral Ischaemia MetaADEDB
Periproctitis MetaADEDB
Perirectal Abscess MetaADEDB
Peritonitis MetaADEDB
Petechiae PROTECT
Peyronie Disease MetaADEDB
Pharyngitis ADReCS
Phosphatase Alkaline Increased SIDER
Phosphorus Low SIDER
Platelet Count Decreased ADReCS
Pleural Disorder ADReCS
Pleural Effusion ADReCS
Pneumonia ADReCS
Pneumonitis PROTECT
Pollakiuria ADReCS
Postoperative Wound Infection PROTECT
Potassium Increased SIDER
Potassium Low SIDER
Proctalgia MetaADEDB
Proctitis MetaADEDB
Protein Total Decreased MetaADEDB
Prothrombin Time Prolonged MetaADEDB
Prurigo ADReCS
Pruritus ADReCS
Pruritus Generalised PROTECT
Pulmonary Embolism ADReCS
Pulmonary Hypertension MetaADEDB
Purulence MetaADEDB
Pyrexia ADReCS
Rash ADReCS
Rash Generalised PROTECT
Rash Macular PROTECT
Rash Maculo-Papular ADReCS
Rash Papular PROTECT
Rash Pruritic PROTECT
Rash Pustular ADReCS
Rectal Haemorrhage PROTECT
Reflex Sympathetic Dystrophy SIDER
Renal Cancer Metastatic MetaADEDB
Renal Failure ADReCS
Renal Injury MetaADEDB
Respiratory Failure MetaADEDB
Respiratory Tract Infection ADReCS
Retroperitoneal Haematoma MetaADEDB
Rhabdomyolysis ADReCS
Rhinitis ADReCS
Scrotal Oedema PROTECT
Sepsis PROTECT
Septic Shock PROTECT
Serum Creatinine Increased SIDER
Sinus Disorder MetaADEDB
Sinusitis PROTECT
Soft Tissue Disorder MetaADEDB
Soft Tissue Necrosis MetaADEDB
Somnolence PROTECT
Spinal Compression Fracture MetaADEDB
Spinal Cord Compression MetaADEDB
Stevens-Johnson Syndrome PROTECT
Stomatitis ADReCS
Streptococcal Bacteraemia MetaADEDB
Subileus MetaADEDB
Sudden Death MetaADEDB
Swelling ADReCS
Thrombocytopenia ADReCS
Thromboembolism ADReCS
Thrombophlebitis ADReCS
Thrombosis ADReCS
Troponin I Increased MetaADEDB
Troponin Increased MetaADEDB
Type Iii Immune Complex Mediated Reaction MetaADEDB
Ulcer ADReCS
Upper Respiratory Tract Infection ADReCS
Urethral Disorder SIDER
Urinary Tract Disorder SIDER
Urinary Tract Infection ADReCS
Urosepsis MetaADEDB
Venous Thromboembolism SIDER
Venous Thrombosis ADReCS
Vertebroplasty MetaADEDB
Vesiculobullous Rash SIDER
Viral Infection PROTECT
Vomiting ADReCS
Weight Decreased ADReCS
White Blood Cell Count Decreased ADReCS
Wound Infection PROTECT

InAADR: Drug-Protein-ADRs database