| Drug Name: | Cephalothin (153-61-7) |
|---|---|
| PubChem ID: | 6024 |
| SMILES: | CC(=O)OCC1=C(N2[C@@H]([C@@H](C2=O)NC(=O)CC3=CC=CS3)SC1)C(=O)O |
| InchiKey: | XIURVHNZVLADCM-IUODEOHRSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 396.446 |
| LogP | : | 0.5923 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 7 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 113.01 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Gentamicin (1403-66-3) | Nephrotoxicity | Additive | Uncertain. The nephrotoxic effects of gentamicin is well documented, and some (mostly older) cephalosporins are known to be nephrotoxic, especially in high dose. However, it appears that doses that are well tolerated separately can be nephrotoxic when given together | Cephalothin plus an aminoglycoside is more nephrotoxic than methicillin plus an aminoglycoside |
| Colistin (1264-72-8) | Renal Failure | Additive | Not known | Adverse effects of sodium colistimethate Manifestations and specific reaction rates during 317 courses of therapy |
| Furosemide (54-31-9) | Nephrotoxicity | Antagonistic | Cefalotin is nephrotoxic, but why this should be increased by furosemide is not understood. It may possibly be related to a reduction in its clearance | Nephrotoxicity and acute renal failure associated with cephalothin and cephaloridine |
| Probenecid (57-66-9) | Nephrotoxicity | Antagonistic | Probenecid inhibits the excretion of most cephalosporins by the kidney tubules by successfully competing for the excretory mechanisms. Thus the cephalosporin is retained in the body and its serum levels rise. The extent of the rise cannot always be fully accounted for by this mechanism alone and it is suggested that some change in tissue distribution may sometimes have a part to play. | Probenecid: an unexplained effect on cephalosporin pharmacology |
| Tobramycin (32986-56-4) | Nephrotoxicity | Additive | Uncertain. The nephrotoxic effects of tobramycin is well documented, and some (mostly older) cephalosporins are known to be nephrotoxic, especially in high dose. However, it appears that doses that are well tolerated separately can be nephrotoxic when given together | Clinical and pharmacokinetic characteristics of aminoglycoside nephrotoxicity in 201 critically ill patients |
| Warfarin (81-81-2) | Hypoprothrombinaemia | Additive | Cephalosporins with an N-methylthiotetrazole side-chain can, like the oral anticoagulants, act as vitamin K antagonists to reduce the production of some blood clotting factors. They can therefore cause bleeding on their own. | Influence of cephalosporin antibiotics on blood coagulation and platelet function |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category