InAADR

Drug Information

Drug Name: Topotecan (119413-54-6)
PubChem ID: 60700
SMILES: CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=C(C5=C4)CN(C)C)O)O
InchiKey: UCFGDBYHRUNTLO-QHCPKHFHSA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 421.453
LogP: 1.8468
Ring Count: 3
Hydrogen Bond Acceptor Count: 8
Hydrogen Bond Donor Count: 2
Total Polar Surface Area: 104.89

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Distension MetaADEDB
Abdominal Pain ADReCS
Accidental Poisoning MetaADEDB
Acquired Oesophageal Web MetaADEDB
Acute Leukaemia SIDER
Acute Respiratory Distress Syndrome SIDER
Adenopathy MetaADEDB
Adenotonsillectomy MetaADEDB
Adverse Drug Effect MetaADEDB
Adynamic Ileus MetaADEDB
Agranulocytoses MetaADEDB
Alanine Aminotransferase Increased SIDER
Allergic Reaction ADReCS
Alopecia ADReCS
Amaurosis Fugax MetaADEDB
Anaemia ADReCS
Anal Discomfort MetaADEDB
Anal Haemorrhage MetaADEDB
Anaphylactic Reaction PROTECT
Anaphylactic Shock ADReCS
Anaphylactoid Reaction ADReCS
Anemia MetaADEDB
Angioedema ADReCS
Angiopathy ADReCS
Anhidrosis MetaADEDB
Anorexia ADReCS
Aortic Aneurysm SIDER
Aortic Dissection SIDER
Arterial Injury MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arthralgia ADReCS
Ascites MetaADEDB
Aspartate Aminotransferase Decreased MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Aspartate Aminotransferase Increased SIDER
Aspergillosis MetaADEDB
Aspiration Pleural Cavity MetaADEDB
Asthenia ADReCS
Atelectasis MetaADEDB
Atrial Flutter MetaADEDB
Atrial Tachycardia MetaADEDB
Attention Deficit/Hyperactivity Disorder MetaADEDB
Back Pain ADReCS
Bacterial Test Positive MetaADEDB
Bacterial Toxaemia MetaADEDB
Basophil Count Decreased MetaADEDB
Basophil Count Increased MetaADEDB
Bedridden MetaADEDB
Bence Jones Protein Urine MetaADEDB
Bile Duct Obstruction MetaADEDB
Bile Duct Stent Insertion MetaADEDB
Bladder Inflammation MetaADEDB
Bleeding Vaginal MetaADEDB
Blood Albumin Decreased MetaADEDB
Blood Albumin Increased MetaADEDB
Blood Alkaline Phosphatase Decreased MetaADEDB
Blood Amylase Increased MetaADEDB
Blood Bilirubin Increased ADReCS
Blood Calcium MetaADEDB
Blood Chloride Decreased MetaADEDB
Blood Chloride Increased MetaADEDB
Blood Creatine Increased MetaADEDB
Blood Creatinine Decreased MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Culture Positive MetaADEDB
Blood Electrolytes Abnormal MetaADEDB
Blood Gases Abnormal MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase Decreased MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Magnesium Decreased MetaADEDB
Blood Phosphorus MetaADEDB
Blood Phosphorus Increased MetaADEDB
Blood Potassium Decreased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Sodium MetaADEDB
Blood Sodium Increased MetaADEDB
Blood Urea Increased MetaADEDB
Body Temperature Increased ADReCS
Bone Disorder ADReCS
Bone Marrow Depression MetaADEDB
Bone Marrow Disorder MetaADEDB
Bone Marrow Failure MetaADEDB
Bone Marrow Transplant MetaADEDB
Bone Pain ADReCS
Bone Scan Abnormal MetaADEDB
Bone Trimming MetaADEDB
Bronchial Secretion Retention MetaADEDB
Bronchiectasis MetaADEDB
Bronchitis MetaADEDB
Bruise MetaADEDB
Bulging MetaADEDB
Bullous Eruption ADReCS
C-Reactive Protein Increased MetaADEDB
C1 Esterase Inhibitor Decreased MetaADEDB
Cachectic MetaADEDB
Caecitis MetaADEDB
Capillary Disorder MetaADEDB
Carcinoma Non-Small-Cell Lung MetaADEDB
Carcinoma Renal Cell MetaADEDB
Cardiac Arrest ADReCS
Catheter Site Erythema MetaADEDB
Catheter Site Infection MetaADEDB
Central Venous Catheterisation MetaADEDB
Cerebellar Syndrome MetaADEDB
Cerebral Disorder MetaADEDB
Cerumen Removal MetaADEDB
Cervix Carcinoma Recurrent MetaADEDB
Chest Pain ADReCS
Chills ADReCS
Choking MetaADEDB
Choking Sensation MetaADEDB
Cholecystitis MetaADEDB
Chronic Tonsillitis MetaADEDB
Circumstance Or Information Capable Of Leading To Medication Error MetaADEDB
Cold Extremities MetaADEDB
Colitis ADReCS
Colonic Obstruction MetaADEDB
Colorectal Cancer MetaADEDB
Condition Aggravated MetaADEDB
Confabulation MetaADEDB
Constipated MetaADEDB
Constipation ADReCS
Continuous Haemodiafiltration MetaADEDB
Coronary Artery Stenosis MetaADEDB
Cough ADReCS
Cramp Muscle SIDER
Csf Lymphocyte Count Increased MetaADEDB
Csf Monocyte Count Decreased MetaADEDB
Csf Monocyte Count Increased MetaADEDB
Culture Positive MetaADEDB
Deafness MetaADEDB
Death ADReCS
Debridement MetaADEDB
Decreased Appetite ADReCS
Dehydration MetaADEDB
Dental Pain MetaADEDB
Depressed Level Of Consciousness MetaADEDB
Dermatitis ADReCS
Dermatitis Bullous ADReCS
Diabetic Acidosis MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Differential White Blood Cell Count Abnormal MetaADEDB
Dilatation Intrahepatic Duct Acquired MetaADEDB
Discomfort ADReCS
Disease Progression MetaADEDB
Diverticulum MetaADEDB
Dizziness Exertional MetaADEDB
Drug Dispensing Error MetaADEDB
Drug Toxicity MetaADEDB
Dysaesthesia MetaADEDB
Dysgeusia MetaADEDB
Dysmenorrhoea ADReCS
Dyspareunia ADReCS
Dyspnoea ADReCS
Dyspnoea Exacerbated MetaADEDB
Ear Ache MetaADEDB
Ear Discomfort MetaADEDB
Ear Pain ADReCS
Eating Disorder MetaADEDB
Eczema MetaADEDB
Effusion ADReCS
Electrocardiogram T Wave Inversion MetaADEDB
Electrolyte Disorder MetaADEDB
Embolism ADReCS
Embolism Pulmonary MetaADEDB
Endophthalmitis MetaADEDB
Engraftment Syndrome MetaADEDB
Enterocolitis Infectious MetaADEDB
Enterocutaneous Fistula MetaADEDB
Enterovesical Fistula MetaADEDB
Eosinophil Count Decreased MetaADEDB
Epistaxis MetaADEDB
Eruption SIDER
Erysipelas MetaADEDB
Escherichia Infection MetaADEDB
Escherichia Urinary Tract Infection MetaADEDB
Esophagitis MetaADEDB
Excess Potassium MetaADEDB
Exfoliative Rash MetaADEDB
Exploratory Operation MetaADEDB
Extravasation ADReCS
Eyelid Function Disorder MetaADEDB
Facial Palsy MetaADEDB
Faecaloma MetaADEDB
Failure To Thrive MetaADEDB
Fatigue ADReCS
Febrile Bone Marrow Aplasia MetaADEDB
Febrile Infection MetaADEDB
Febrile Neutropenia ADReCS
Feeding Tube Insertion MetaADEDB
Feeling Abnormal ADReCS
Fever MetaADEDB
Flank Pain MetaADEDB
Floaters MetaADEDB
Gallbladder Non-Functioning MetaADEDB
Gallbladder Perforation MetaADEDB
Gangrene MetaADEDB
Gardnerella Infection MetaADEDB
Gastric Polyps MetaADEDB
Gastric Ulcer Haemorrhage MetaADEDB
Gastroenteritis Cryptosporidial MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Diseases MetaADEDB
Gastrointestinal Disorder SIDER
Gastrointestinal Motility Disorder MetaADEDB
Gastrointestinal Pain ADReCS
Gastrointestinal Toxicity MetaADEDB
General Physical Health Deterioration MetaADEDB
Genital Burning Sensation MetaADEDB
Glioblastoma MetaADEDB
Glucose Urine MetaADEDB
Haematemesis MetaADEDB
Haematotoxicity MetaADEDB
Haemoglobin ADReCS
Haemoglobin Abnormal MetaADEDB
Haemorrhage ADReCS
Haemorrhage Rectum MetaADEDB
Haemorrhagic Anaemia MetaADEDB
Headache ADReCS
Hematologic Diseases MetaADEDB
Hepatic Cancer Metastatic MetaADEDB
Hepatic Enzyme Increased ADReCS
Hepatic Pain ADReCS
Hepatitis B Positive MetaADEDB
Hepatobiliary Disease SIDER
Hernia Hiatal MetaADEDB
Hiccough MetaADEDB
High Density Lipoprotein Decreased MetaADEDB
Hydronephrosis MetaADEDB
Hyperbilirubinaemia ADReCS
Hyperchloraemia MetaADEDB
Hyperhidrosis ADReCS
Hyperlipaemia MetaADEDB
Hypersensitivity ADReCS
Hypoalbuminaemia MetaADEDB
Hypokalaemia MetaADEDB
Hypomagnesaemia MetaADEDB
Hypophagia MetaADEDB
Hypoproteinaemia MetaADEDB
Hypotension MetaADEDB
Hypotension Orthostatic MetaADEDB
Hypovolaemia MetaADEDB
Hypoxia MetaADEDB
Ileitis MetaADEDB
Ill-Defined Disorder ADReCS
Immune System Disorder SIDER
Impaired Self-Care MetaADEDB
Increased Platelet Count MetaADEDB
Infection ADReCS
Infection Viral MetaADEDB
Infestation SIDER
Infestation Nos SIDER
Infrequent Bowel Movements MetaADEDB
Interstitial Lung Disease ADReCS
Intestinal Mucosal Hypertrophy MetaADEDB
Intestinal Obstruction ADReCS
Kawasaki Disease MetaADEDB
Left Ventricular Hypertrophy MetaADEDB
Lethargy ADReCS
Leucopenia MetaADEDB
Leukemia MetaADEDB
Leukocyturia MetaADEDB
Leukopenia ADReCS
Leukopenia Neonatal MetaADEDB
Lipase MetaADEDB
Lipids Increased MetaADEDB
Local Swelling MetaADEDB
Loss Of Weight MetaADEDB
Lung Cancer Metastatic MetaADEDB
Lung Disorder ADReCS
Lung Neoplasm Malignant MetaADEDB
Lymphocyte Count Decreased MetaADEDB
Lymphoma Non-Hodgkin MetaADEDB
Lymphopenia MetaADEDB
Malaise ADReCS
Malignant Ascites MetaADEDB
Malnourished MetaADEDB
Mechanical Ventilation MetaADEDB
Mediastinal Disorder SIDER
Melanoma MetaADEDB
Mental Status Changes MetaADEDB
Metastases To Central Nervous System MetaADEDB
Metastases To Heart MetaADEDB
Metastases To Liver MetaADEDB
Metastases To Pancreas MetaADEDB
Metastases To Thyroid MetaADEDB
Middle Ear Inflammation MetaADEDB
Mixed Liver Injury MetaADEDB
Monoplegia MetaADEDB
Mucosal Inflammation PROTECT
Multi-Organ Failure MetaADEDB
Multiple Myeloma MetaADEDB
Muscle Spasms ADReCS
Musculoskeletal Discomfort ADReCS
Myalgia ADReCS
Myelodysplastic Syndromes MetaADEDB
Myelopathy MetaADEDB
Myelosuppression SIDER
Nail Disorder MetaADEDB
Nausea ADReCS
Neck Mass MetaADEDB
Necrotising Fasciitis Streptococcal MetaADEDB
Neoplasm ADReCS
Neoplasm Malignant ADReCS
Neoplasms MetaADEDB
Nervous System Disorder SIDER
Neumonia MetaADEDB
Neuralgia ADReCS
Neuroblastoma MetaADEDB
Neuropathy ADReCS
Neuropathy Peripheral ADReCS
Neutropenia ADReCS
Neutropenic Colitis ADReCS
Neutropenic Infection MetaADEDB
Neutrophil Count Abnormal MetaADEDB
Neutrophil Count Decreased MetaADEDB
Neutrophil Toxic Granulation Present MetaADEDB
Obstruction ADReCS
Obstructive Airways Disorder MetaADEDB
Oesophageal Cancer Metastatic MetaADEDB
Optic Neuropathy MetaADEDB
Oral Fungal Infection MetaADEDB
Osteoporosis MetaADEDB
Ovarian Cancer ADReCS
Ovarian Cancer Metastatic MetaADEDB
Ovarian Cancer Recurrent MetaADEDB
Ovarian Carcinoma SIDER
Ovarian Epithelial Cancer Stage Iv ADReCS
Ovarian Neoplasms MetaADEDB
Pain ADReCS
Painful Respiration MetaADEDB
Pancreatic Duct Dilatation MetaADEDB
Pancytopenia ADReCS
Paraesthesia ADReCS
Pelvic Pain ADReCS
Performance Status Decreased MetaADEDB
Peritonitis MetaADEDB
Pharyngeal Inflammation MetaADEDB
Pharyngitis ADReCS
Pharyngitis Streptococcal MetaADEDB
Platelet Count MetaADEDB
Platelet Count Abnormal MetaADEDB
Platelet Disorder MetaADEDB
Pleural Disorder ADReCS
Pleural Effusion ADReCS
Pleuritic Pain ADReCS
Pneumonia ADReCS
Pneumonia Viral MetaADEDB
Pneumothorax Traumatic MetaADEDB
Po2 Decreased MetaADEDB
Portal Vein Occlusion MetaADEDB
Protein Total Decreased MetaADEDB
Pruritus ADReCS
Pseudomonas Infection MetaADEDB
Pseudophakia MetaADEDB
Pulmonary Embolism ADReCS
Pulmonary Hilum Mass MetaADEDB
Pulmonary Thrombosis MetaADEDB
Pyelonephritis MetaADEDB
Pyrexia ADReCS
Radiation Pneumonitis MetaADEDB
Radiation Skin Injury MetaADEDB
Radiotherapy MetaADEDB
Rash ADReCS
Rash Erythematous ADReCS
Rash Maculo-Papular ADReCS
Respiratory Depth Decreased MetaADEDB
Respiratory Distress ADReCS
Respiratory Failure ADReCS
Retrograde Amnesia MetaADEDB
Rhabdomyosarcoma MetaADEDB
Rhinitis MetaADEDB
Rigors SIDER
Sclc MetaADEDB
Scleroderma Localized MetaADEDB
Scoliosis MetaADEDB
Second Primary Malignancy SIDER
Sepsis ADReCS
Sinus Disorder MetaADEDB
Sinus Rhythm MetaADEDB
Small Cell Lung Carcinoma MetaADEDB
Spinning Sensation MetaADEDB
Splenic Haemorrhage MetaADEDB
Squamous Cell Carcinoma Of The Cervix MetaADEDB
Stent Occlusion MetaADEDB
Stent Removal MetaADEDB
Stomatitis ADReCS
Streptococcal Infection MetaADEDB
Subileus MetaADEDB
Surgery MetaADEDB
Sweating SIDER
Tetany MetaADEDB
Thrombocytopenia ADReCS
Tongue Biting MetaADEDB
Tooth Hypoplasia MetaADEDB
Tooth Infection MetaADEDB
Tumour Haemorrhage PROTECT
Tumour Pain ADReCS
Ureteral Stent Insertion MetaADEDB
Urethritis MetaADEDB
Urge Incontinence MetaADEDB
Urinary Sediment Present MetaADEDB
Urinary Tract Disorder MetaADEDB
Urine Odour Abnormal MetaADEDB
Urobilin Urine Present MetaADEDB
Urticaria ADReCS
Vascular Neoplasm MetaADEDB
Venous Thrombosis Limb MetaADEDB
Very Low Density Lipoprotein Increased MetaADEDB
Vestibular Disorder MetaADEDB
Vomiting ADReCS
Weight Increased ADReCS
White Blood Cell Count Abnormal MetaADEDB
White Blood Cell Disorder MetaADEDB
Wound MetaADEDB

InAADR: Drug-Protein-ADRs database