| Drug Name: | Baclofen (1134-47-0) |
|---|---|
| PubChem ID: | 2284 |
| SMILES: | C1=CC(=CC=C1C(CC(=O)O)CN)Cl |
| InchiKey: | KPYSYYIEGFHWSV-UHFFFAOYSA-N |
| Therapeutic Category: | Central Nervous System Agents, GABA Agents, GABA Agonists, GABA-B Receptor Agonists, Muscle Relaxants, Neuromuscular Agents, Neurotransmitter Agents, Peripheral Nervous System Agents |
| Molecular Weight (dalton) | : | 213.664 |
| LogP | : | 1.857 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 2 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 63.32 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Levodopa (59-92-7) | Confusion | Antagonistic | Not understood | Baclofen in Parkinson's disease |
| Levodopa (59-92-7) | Hallucinations! | Antagonistic | Not understood | Baclofen in Parkinson's disease |
| Levodopa (59-92-7) | Headache | Antagonistic | Not understood | Baclofen in Parkinson's disease |
| Levodopa (59-92-7) | Nausea | Antagonistic | Not understood | Baclofen in Parkinson's disease |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Threshold Normalization | Adenosine A1 receptor (P30542) | In SCS responding rats@ combination of a selective GABA(B) and an adenosine A1 receptor antaGOnist (CGP 55845@ CPT) in low@ ineffective doses abolished the SCS-induced threshold normalization [ ADR Type 1 ] | Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABA(B) and adenosine receptor activation |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category