| Drug Name: | Tacrolimus (104987-11-3) |
|---|---|
| PubChem ID: | 5282315 |
| SMILES: | C[C@@H]1C[C@@H]([C@@H]2[C@H](C[C@H]([C@@](O2)(C(=O)C(=O)N3CCCC[C@H]3C(=O)O[C@@H]([C@@H]([C@H](CC(=O)[C@@H](/C=C(/C1)C)CC=C)O)C)/C(=C/[C@@H]4CC[C@H]([C@@H](C4)OC)O)/C)O)C)OC)OC.O |
| InchiKey: | NWJQLQGQZSIBAF-MLAUYUEBSA-N |
| Therapeutic Category: | Immunologic Factors, Immunosuppressive Agents |
| Molecular Weight (dalton) | : | 822.046 |
| LogP | : | 3.8143 |
| Ring Count | : | 0 |
| Hydrogen Bond Acceptor Count | : | 12 |
| Hydrogen Bond Donor Count | : | 3 |
| Total Polar Surface Area | : | 209.86 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Nephrotoxicity | Calcineurin (P63098) | Cyclosporine A and FK506 nephrotoxicity may reflect renal-specific functions of calcineurin [ ADR Type 2 ] | Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|---|---|
| Grapefruit Juice | Nephrotoxicity | Grapefruit-medication interactions: forbidden fruit or avoidable consequences? |
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category