| TanCanDB: A Knowledge-base for Tankyrase Cancer Target | |
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| Tankyrases are members of the human poly (ADP-ribose) polymerase (PARP) protein superfamily also called as Diphtheria toxins-like ADP-ribosyltransferases (ARTDs). These tankyrases play a vital role in the Wnt/β-catenin signaling pathway. TNKS is a potential target for therapeutic intervention against various caners, heritable disease (cherubism) and implications in the replication of herpes simplex virus (HSV). Several studies suggest that TNKSs have gained increased attention as a drug target because of their role in the regulation of telomere length, lung fibreogenesis, assembly of mitotic spindle and mylination. Therefore inhibition of TNKS activity appears to be a potential target for cancer therapy |  |
| Here, we present, the TanCanDB (Tankyrase Cancer) Database, to get access to all the information related to tankyrases crystal structures, their inhibitors, literatures and researchers working on them to common people easily in a user-friendly interface. TanCanDB is a freely available assortment of tankyrases associated data that facilitate the study in the field of tankyrases, PARP and cancer drug designing. TanCanDB provides bioassays, and patents associated with PARP and TNKSs. Various customizable options are available for searching information. | |