| Proteasome beta 6 subunit, putative [Q4QJ65] | |
|---|---|
| Systematic Name | LmjF.06.0140 [Leishmania major] |
| Gene Name | LMJF_06_0140 |
| Molecular Weight | 27967 Da |
| Protein Sequence Size | 247 |
| Function | |
| Charge | 2.5 |
| Isoelectric Point | 7 pH |
| Description | Proteasome beta 6 subunit, putative (20s proteasome beta 6 subunit, putative). |
| Subcellular Location | proteasome core complex (sensu Eukaryota)[Predict] |
| E. C. Number | 3.4.25.1 |
| Sequence | >tr|Q4QJ65|Q4QJ65_LEIMA Proteasome beta 6 subunit, putative (20s proteasome beta 6 subunit, putative) - Leishmania major. IEDHAEYGHSHYPQKLASSTLTLPKQGVKQQQWSPYHDNGGTTAAIAGKDFVILAGDTRL NGDYCLHSRHDQSKIFQLTPYTYMASNGMQADRLQLQQMLKYRVKWYQYNNGGKVPPTKA IAQLMSTMLYHRRFFPYYTFNMVVGLDEEGHGVCYSYDAVGSTEPFLYGTRGSAASFLEP VLDCLINRQHMTAQAPPEMTKEETLALLKNAFTGAAERDIYTGDSVSFFIITKDGVQRES FELRKD |
| DNA Sequence | >LmjF06.0140 |||proteasome beta 6 subunit, putative|Leishmania major|chr 6|||Manual ATGATCGAGG ACCACGCCGA GTACGGCCAC AGCCACTACC CCCAGAAGCT GGCCAGCTCTACCCTCACCC TGCCGAAGCA GGGGGTGAAG CAGCAGCAGT GGAGCCCCTA CCATGACAATGGCGGCACGA CGGCCGCTAT CGCTGGCAAG GACTTCGTCA TCCTCGCTGG TGACACTCGTCTGAACGGTG ACTACTGCCT TCACAGCCGC CATGATCAGA GCAAGATCTT CCAGCTGACGCCGTACACGT ATATGGCGAG CAACGGCATG CAGGCGGACC GACTGCAGCT CCAGCAGATGCTCAAGTACC GCGTCAAGTG GTACCAGTAC AACAACGGCG GTAAGGTGCC GCCGACCAAGGCGATTGCGC AGCTCATGTC CACGATGCTG TACCACCGTC GCTTCTTCCC TTACTACACATTCAATATGG TCGTTGGTCT GGATGAAGAG GGGCACGGCG TGTGCTACAG CTACGACGCCGTCGGCTCAA CGGAGCCCTT CCTGTACGGC ACCCGGGGTA GTGCGGCCAG CTTCTTGGAGCCGGTGCTCG ACTGCCTCAT CAACCGCCAG CATATGACCG CTCAGGCACC GCCGGAGATGACAAAGGAGG AGACGCTGGC GCTGCTCAAG AACGCCTTCA CCGGCGCAGC CGAGCGCGACATTTACACTG GCGACTCCGT CTCCTTCTTC ATCATCACGA AGGACGGCGT GCAGCGGGAGAGCTTCGAGC TGCGCAAGGA CTGA |
| Proteasome beta 6 subunit, putative Q4QJ65] | |
|---|---|
| Metabolite Information | |
| Molecular Function | threonine endopeptidase activity |
| Biochemical Pathway | ubiquitin-dependent protein catabolism |
| Regulatory Pathway | |
| KEGG Pathways | K02732 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | proteasome beta 1 subunit [Homo sapiens] | 43 | 3e-47 | 185 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YBL041w 20S proteasome subunit(beta6) | Saccharomyces cerevisiae | 39% | 2e-42 | 166 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00668 | Proteasome B-type subunits signature | 45-93; | PS00854 | |
| Acylation | N-myristoylation site | 41-46; 42-47; 153-158; 170-175; 173-178; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 69-72; 177-180; 201-204; | PS00006 | |
| Sulfation | Tyrosine sulfation site | 215-229; | PS00003 | |
| Proteasome beta 6 subunit, putative [Q4QJ65] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1iruM | |
| Percent Identity | 43% | |
| Target Region | 33-247 | |
| Template Region | 1-213 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 7791-18-6 | MAGNESIUM ION | 24.305 | Mg | [Mg+2] | 1iru |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/580971/Q4QJ65.pdb 2.0 215 = residues | | = | *| Ramachandran plot: 92.0% core 7.0% allow 0.5% gener 0.5% = disall | | = | +| All Ramachandrans: 5 labelled residues (out of 213) = | +| Chi1-chi2 plots: 3 labelled residues (out of 131) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 0 | *| Bond len/angle: 6.6 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.03 Covalent: -0.23 Overall: = -0.06 | | = | | M/c bond lengths: 99.2% within limits 0.8% highlighted = | | M/c bond angles: 92.2% within limits 7.8% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |