| RNA helicase, putative [Q4QC38] | |
|---|---|
| Systematic Name | LmjF.21.1552 [Leishmania major] |
| Gene Name | LMJF_21_1552 |
| Molecular Weight | 49488 Da |
| Protein Sequence Size | 435 |
| Function | |
| Charge | -2 |
| Isoelectric Point | 6.1455 pH |
| Description | RNA helicase, putative. |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4QC38|Q4QC38_LEIMA RNA helicase, putative - Leishmania major SSDLADFDGDDVRTTVVAAQPMGVGMGTHSAVALGGFQDFCLKSELANAIRENGFEHPSE VQHQALPKAMLGADILAQAKSGMGKTAVFVFALLEQVEKVPQGQKPYCQAVVLVHARELA YQIEQEFKRFSKYLPYATTGVFFGGIPEDENVKQLKKEVPAIIVGTPGRMKALIQNKAFD TTHVKWFVVDEFDRCLEDVKMRRDVQEIFMKLPKEKQVMMFSATMTDELRDVAKKFMKDA TEIYVDQRAKLTLHGLAQFYMNVTEPEKTRRLAEILDVVEFNQAIIFTSSVERCEALNRQ LQQMKFPSQAVHSRMSQEERLRVYESCKANNTRIMVATDLFGRGVDFDRINLVVQYDMAS EADSYLHRVGRAGRFGTKGLTIAFITTDEKEIKRENRTYTDGGIMKEVQERFEMKVEELT DINTQLNENQYMNK |
| DNA Sequence | >LmjF21.1552 |||RNA helicase, putative|Leishmania major|chr 21|||Manual ATGAGCAGCG ATCTTGCGGA CTTCGACGGC GATGATGTCA GGACCACCGT CGTGGCGGCACAGCCGATGG GCGTCGGAAT GGGCACCCAC AGCGCCGTCG CCCTCGGTGG CTTCCAGGACTTCTGCCTGA AGAGCGAGCT TGCGAACGCC ATCCGCGAGA ACGGCTTCGA GCACCCGTCGGAGGTGCAAC ACCAGGCGCT GCCCAAGGCG ATGCTCGGCG CTGACATTCT CGCCCAGGCCAAGTCGGGTA TGGGTAAGAC GGCCGTCTTC GTCTTTGCGC TGCTGGAGCA GGTGGAGAAGGTGCCGCAGG GACAGAAGCC GTACTGCCAG GCCGTCGTGC TGGTGCACGC CCGCGAGCTGGCCTACCAGA TTGAGCAGGA GTTCAAGCGC TTCAGCAAGT ACCTCCCGTA CGCCACCACAGGCGTCTTCT TCGGCGGCAT CCCGGAGGAC GAGAACGTGA AACAGCTGAA GAAGGAGGTGCCAGCGATCA TCGTCGGTAC GCCAGGCCGC ATGAAGGCGC TCATCCAGAA CAAGGCCTTTGACACGACGC ACGTGAAGTG GTTTGTGGTC GACGAGTTCG ACCGCTGCCT AGAAGACGTGAAGATGCGCC GTGACGTGCA GGAGATTTTC ATGAAGCTGC CGAAGGAGAA GCAGGTGATGATGTTCTCTG CCACGATGAC GGATGAGCTG CGCGATGTGG CAAAGAAGTT CATGAAGGACGCGACGGAGA TTTACGTGGA TCAGCGGGCA AAGCTGACCC TGCACGGTCT GGCGCAGTTCTACATGAACG TCACGGAGCC GGAGAAGACG CGCCGGCTGG CAGAGATCCT CGACGTTGTGGAGTTCAACC AGGCGATCAT CTTCACATCC TCGGTCGAGC GCTGCGAGGC GCTGAACCGCCAGCTACAGC AGATGAAGTT CCCGTCGCAG GCCGTGCATT CCCGCATGAG CCAGGAGGAGCGCCTGCGCG TGTACGAGAG CTGCAAGGCG AACAACACCC GCATCATGGT TGCCACCGACCTCTTCGGCC GCGGAGTCGA CTTTGACCGC ATCAACCTCG TTGTGCAGTA CGACATGGCCTCCGAGGCTG ACAGCTACCT TCACCGAGTC GGCCGCGCCG GCCGCTTCGG TACGAAGGGACTGACAATCG CCTTCATCAC GACAGACGAA AAGGAGATCA AGCGCGAGAA CCGCACCTACACGGATGGCG GCATCATGAA GGAGGTGCAG GAGCGCTTCG AGATGAAGGT CGAGGAGCTGACGGACATCA ACACCCAGCT GAACGAGAAC CAGTACATGA ACAAGTAA |
| RNA helicase, putative Q4QC38] | |
|---|---|
| Metabolite Information | |
| Molecular Function | ATP binding; ATP-dependent helicase activity; helicase activity; nucleic acid binding |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | HLA-B associated transcript 1 [Homo sapiens] | 50 | 1e-115 | 413 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YDR021w involved in maturation of 18S rRNA | Saccharomyces cerevisiae | 35% | 3e-61 | 229 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00017 | ATP/GTP-binding site motif A (P-loop) | 80-87; | PS00017 | |
| PDOC51195 | DEAD-box RNA helicase Q motif profile | 9.178 | 36-64 | PS51195 |
| PDOC51192 | Superfamilies 1 and 2 helicase domain profiles | 23.002 | 67-244 | PS51192 |
| PDOC51192 | Superfamilies 1 and 2 helicase domain profiles | 20.368 | 272-421 | PS51194 |
| Acylation | N-myristoylation site | 24-29; 28-33; 83-88; 141-146; 380-385; | PS00008 | |
| Glycosylation | N-glycosylation site | 263-266; 331-334; 397-400; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 129-132; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 225-228; 265-268; 290-293; 317-320; 361-364; 387-390; 399-402; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 270-272; 327-329; | PS00005 | |
| Sulfation | Tyrosine sulfation site | 238-252; | PS00003 | |
| RNA helicase, putative [Q4QC38] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 1xtkA | |
| Percent Identity | 53% | |
| Target Region | 40-235 | |
| Template Region | 49-382 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 60-24-2 | BETA-MERCAPTOETHANOL | 78.133 | C2 H6 O S | OCCS | 1xtk |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/285131/Q4QC38.pdb 2.0 396 = residues | | = | *| Ramachandran plot: 90.7% core 8.2% allow 0.8% gener 0.3% = disall | | = | +| All Ramachandrans: 9 labelled residues (out of 394) = | +| Chi1-chi2 plots: 1 labelled residues (out of 261) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.5 Bad contacts: = 10 | *| Bond len/angle: 6.9 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.10 Covalent: -0.12 Overall: = 0.02 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | | M/c bond angles: 94.4% within limits 5.6% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |