| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C7] | |
|---|---|
| Systematic Name | LmjF.34.0790 [Leishmania major] |
| Gene Name | LMJF_34_0790 |
| Molecular Weight | 34680 Da |
| Protein Sequence Size | 304 |
| Function | |
| Charge | -10 |
| Isoelectric Point | 4.6232 pH |
| Description | Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 3.1.3.16 |
| Sequence | >tr|Q4Q3C7|Q4Q3C7_LEIMA Serine/threonine-protein phosphatase PP1, putative (EC 3.1.3.16) - Leishmania major. ASSTSPSSSAVPQTLIEKLLTVRGASTQRQVLIKEEDIRVVLENVREIFMSQPMLLEIRP PVRVCGDTHGQYYDLLRIYEKCGFPPYSNYLFLGDYVDRGKQSVETIVLQFCYKIVYPEN FFLLRGNHECASINKMYGFFDDVKRRYNIKLFKAFTDVFNTMPVCCVISEKIICMHGGLS PDLTDLTAINEILRPCDVPDRGILCDLLWADPENEVRGFLESDRGVSYLFGEDIVNDFLD MVDMDLIVRAHQVVQRGYEFFASRQLVTVFSAPNYCGEFDNDAAVMTIDDKLQCSFLIIP AAK |
| DNA Sequence | >LmjF34.0790 |||serine/threonine-protein phosphatase PP1, putative|Leishmania major|chr 34|||Manual ATGGCGAGCT CTACCTCGCC CTCCTCCTCC GCAGTGCCGC AGACGCTAAT AGAAAAACTGCTGACGGTCC GTGGTGCCTC CACACAACGC CAAGTGCTCA TCAAGGAGGA GGATATACGAGTGGTGTTGG AGAATGTCCG AGAGATCTTC ATGTCGCAGC CGATGCTCCT CGAGATCCGCCCGCCTGTGC GCGTGTGCGG GGACACGCAC GGACAGTACT ACGACCTGCT GCGCATCTACGAGAAGTGCG GCTTCCCCCC ATACTCGAAC TACCTGTTCC TCGGCGACTA CGTTGACCGCGGCAAGCAGA GCGTCGAGAC GATTGTCTTG CAGTTCTGCT ACAAGATTGT GTACCCCGAGAACTTCTTTC TTCTGCGCGG CAACCACGAG TGCGCTAGCA TCAACAAGAT GTACGGTTTTTTCGATGATG TGAAGCGGCG GTATAACATC AAGCTGTTCA AGGCGTTCAC GGATGTGTTCAACACGATGC CCGTGTGCTG CGTGATTAGC GAGAAGATCA TCTGCATGCA CGGTGGCCTTAGTCCTGACC TGACCGATCT TACCGCCATT AACGAGATTC TTCGTCCGTG CGACGTGCCTGATCGCGGCA TCCTGTGCGA TCTGCTGTGG GCGGACCCAG AAAACGAAGT TCGCGGCTTCCTGGAGAGCG ACCGCGGCGT GAGCTACCTG TTCGGCGAGG ACATTGTGAA CGACTTCCTGGACATGGTGG ACATGGACCT GATTGTGCGC GCGCACCAGG TTGTGCAACG CGGCTATGAGTTCTTTGCGA GCCGTCAGCT TGTGACCGTG TTCTCTGCGC CGAACTACTG CGGTGAGTTTGACAACGACG CTGCCGTGAT GACCATCGAC GACAAGCTGC AGTGCTCCTT CCTGATTATTCCAGCTGCGA AGTAG |
| Serine/threonine-protein phosphatase PP1, putative Q4Q3C7] | |
|---|---|
| Metabolite Information | protein amino acid dephosphorylation |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | protein phosphatase 1, catalytic subunit, gamma isoform [Homo sapiens] | 62 | 1e-111 | 397 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YER133w serthr phosphoprotein phosphatase 1, catalytic chain | Saccharomyces cerevisiae | 62% | 1e-112 | 400 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00115 | Serine/threonine specific protein phosphatases signature | 125-130; | PS00125 | |
| Acylation | N-myristoylation site | 127-132; | PS00008 | |
| Phosphorylation | Casein kinase II phosphorylation site | 15-18; 288-291; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 22-24; 28-30; 170-172; 223-225; | PS00005 | |
| Serine/threonine-protein phosphatase PP1, putative [Q4Q3C7] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2o8gB | |
| Percent Identity | 62% | |
| Target Region | 1-304 | |
| Template Region | 6-295 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| ASP | 99 | Sidechain |
| ARG | 100 | Sidechain |
| ASN | 128 | Sidechain |
| HIS | 129 | Sidechain |
| ARG | 225 | Sidechain |
| HIS | 252 | Sidechain |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 16397-91-4 | MANGANESE (II) ION | 54.938 | Mn | [Mn+2] | 2o8g |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/2680687/Q4Q3C7.pdb 2.0 304 = residues | | = | *| Ramachandran plot: 90.4% core 8.1% allow 0.7% gener 0.7% = disall | | = | +| All Ramachandrans: 6 labelled residues (out of 302) = | | Chi1-chi2 plots: 0 labelled residues (out of 191) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 2 | *| Bond len/angle: 6.3 Morris et al class: 1 = 1 2 | +| 3 cis-peptides = | | G-factors Dihedrals: 0.05 Covalent: -0.09 Overall: = 0.00 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 94.6% within limits 5.4% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |