| Centrin, putative [Q4Q2W1] | |
|---|---|
| Systematic Name | LmjF.34.2390 [Leishmania major] |
| Gene Name | LMJF_34_2390 |
| Molecular Weight | 20784 Da |
| Protein Sequence Size | 181 |
| Function | |
| Charge | -15.5 |
| Isoelectric Point | 4.2028 pH |
| Description | Centrin, putative. |
| Subcellular Location | centrosome[Predict] |
| E. C. Number | N.A. |
| Sequence | >tr|Q4Q2W1|Q4Q2W1_LEIMA Centrin, putative - Leishmania major. NITSRTSGPLRTTAPAASAPSAAARRRFQLTEEQRQEIREAFELFDSDKNGLIDVHEMKV SMRALGFDAKREEVLQLMQDCAARDQNNQPLMDLPGFTDIMTDKFAQRDPRQEMVKAFQL FDENNTGKISLRSLRRVARELGENMSDEELQAMIDEFDVDQDGEINLEEFLAIMLEEDDY |
| DNA Sequence | >LmjF34.2390 |||centrin, putative|Leishmania major|chr 34|||Manual ATGAACATCA CTAGTCGCAC ATCGGGGCCT CTGCGCACCA CTGCGCCGGC GGCATCAGCGCCGTCCGCGG CAGCGCGCCG TCGCTTTCAG CTTACGGAGG AGCAGCGCCA GGAGATCCGAGAGGCATTTG AGCTGTTCGA CTCGGATAAG AACGGACTCA TCGATGTGCA TGAGATGAAGGTGAGCATGC GGGCGCTTGG CTTTGATGCA AAGCGGGAGG AGGTGCTGCA GCTCATGCAGGACTGCGCTG CCAGGGACCA GAACAATCAG CCGCTGATGG ACTTACCGGG CTTCACAGATATCATGACGG ACAAGTTTGC GCAACGCGAT CCTCGGCAGG AGATGGTGAA GGCGTTTCAGCTGTTTGACG AGAACAATAC CGGCAAAATC TCCCTTCGCT CGCTGCGTCG TGTGGCGCGGGAACTGGGCG AGAACATGAG CGACGAAGAG CTGCAGGCGA TGATTGACGA GTTTGACGTTGACCAAGATG GCGAGATCAA CCTAGAAGAG TTTCTTGCCA TTATGCTAGA GGAGGACGACTACTAG |
| Centrin, putative Q4Q2W1] | |
|---|---|
| Metabolite Information | biological process unknown |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | centrin 3 [Homo sapiens] | 59 | 3e-45 | 177 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| YOR257w spindle pole body component, centrin | Saccharomyces cerevisiae | 53% | 7e-40 | 157 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00018 | EF-hand calcium-binding domain signature and profile | 47-59; 159-171; | PS00018 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 2-5; 125-128; 145-148; | PS00722 | |
| Glycosylation | N-glycosylation site | 2-5; 125-128; 145-148; | PS00001 | |
| Phosphorylation | Casein kinase II phosphorylation site | 147-150; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 4-6; 48-50; 62-64; 103-105; 127-129; 131-133; 134-136; | PS00005 | |
| Centrin, putative [Q4Q2W1] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2ggmB | |
| Percent Identity | 52% | |
| Target Region | 31-181 | |
| Template Region | 25-144 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 17787-72-3 | CALCIUM ION | 40.078 | Ca | [Ca+2] | 2ggm |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/3046628/Q4Q2W1.pdb 2.0 151 = residues | | = | +| Ramachandran plot: 91.4% core 6.4% allow 2.1% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 149) = | +| Chi1-chi2 plots: 1 labelled residues (out of 116) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 2.7 Bad contacts: = 6 | *| Bond len/angle: 5.9 Morris et al class: 1 = 1 2 | +| 1 cis-peptides = | | G-factors Dihedrals: 0.23 Covalent: -0.14 Overall: = 0.10 | | = | | M/c bond lengths: 98.9% within limits 1.1% highlighted = | | M/c bond angles: 93.0% within limits 7.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |