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Mitochondrial ATP-dependent zinc metallopeptidase, putative [Q4Q1E9]
Systematic NameLmjF.36.2710 [Leishmania major]
Gene NameLMJF_36_2710
Molecular Weight62188 Da
Protein Sequence Size571
Function
Charge-6.5
Isoelectric Point5.4 pH
DescriptionMitochondrial ATP-dependent zinc metallopeptidase, putative (Metallo-peptidase, clan ma(E), family m41).
Subcellular Locationmembrane; Mitochondrion[Predict]
E. C. Number N.A.
Sequence>tr|Q4Q1E9|Q4Q1E9_LEIMA Mitochondrial ATP-dependent zinc metallopeptidase, putative (Metallo- peptidase, clan ma(E), family m41) - Leishmania major.
SYGQPQQQPLPSDLGTKERPIVVVSAPQKASWATRFWMFLLFGIALSCFISLVEEFNDRF
QEGQPANKSGFARSGISGLFGSVDVKPVNLDNLEVTFDSIRGCDEAKKELEEIVEFLKDP
EKFYNLGGRLPKGALLTGPPGCGKTMLAKAIAKEAGVSFFYATGSEFDEMFVGVGARRVR
ELFAAAKANSPALIFIDEVDALGGRRSRSDHSTSRMTLNQLLAEMDGFDSDEAVIVLAAT
NTPETLDKALTRPGRLDTTITVDPPDMKGRAEVAQVYLDKIKTDSTVNAMDIARGTTGFT
GAELSNLVNLAAIRAAVLNKAKVTSEEIEYAKDRVMMGAESKKIVPEEERRVTAFHEGGH
ALSAILLKDEGADPVHKATIVPRGNGIMGLVQQQPDRDKYSQSKRQCLARLKVCVAGRVG
EEILLGPDDITTGAGSDFQQATNMARHMVRQFGFSDAMGFVDYGTPDTAEGAYISDETKL
KIEKEVHRLVEQAYIETKELLLSHRAELENIANNLLKYETLSGKDLEKIIKGEAIPERPP
RLSQAAESKAAPPRGGNSDQANGRRTVPIS
DNA Sequence>LmjF36.2710 |||mitochondrial ATP-dependent zinc metallopeptidase, putative|Leishmania major|chr 36|||Manual
ATGTCGTATG GGCAGCCACA ACAGCAGCCA CTCCCAAGTG ATCTGGGGAC CAAGGAAAGACCGATTGTGG TCGTGTCAGC ACCGCAGAAG GCTTCCTGGG CCACCCGCTT CTGGATGTTCTTGCTCTTCG GGATTGCTCT TAGCTGCTTC ATCAGCCTGG TCGAGGAGTT CAACGATCGCTTTCAGGAGG GCCAGCCCGC AAACAAGTCA GGATTTGCGC GCTCTGGCAT ATCTGGCCTGTTCGGCTCTG TCGACGTGAA GCCGGTGAAT CTGGACAACT TGGAGGTCAC ATTTGACAGCATCCGCGGAT GCGATGAGGC GAAAAAAGAG CTGGAGGAGA TTGTTGAGTT TCTAAAGGACCCCGAGAAGT TCTACAATTT GGGTGGGCGG CTGCCAAAAG GAGCGCTGCT CACCGGTCCGCCAGGGTGCG GGAAAACCAT GCTGGCAAAG GCGATTGCCA AAGAGGCTGG CGTGAGCTTTTTCTACGCCA CCGGAAGCGA GTTCGATGAG ATGTTTGTTG GCGTTGGCGC CCGCCGCGTTCGCGAACTTT TCGCGGCCGC AAAGGCCAAC TCACCAGCTT TGATTTTCAT CGACGAGGTAGACGCATTAG GCGGTCGCCG CTCTCGTTCT GACCACAGCA CCTCTCGCAT GACGTTGAACCAGCTCCTGG CAGAGATGGA CGGCTTCGAC TCCGATGAGG CCGTTATTGT CCTCGCCGCCACGAACACCC CTGAAACGCT GGACAAGGCA CTCACGCGCC CCGGTCGCCT GGACACCACCATCACCGTTG ACCCTCCGGA TATGAAAGGG CGCGCGGAGG TAGCTCAGGT GTACCTTGACAAAATCAAGA CAGACAGCAC GGTCAATGCA ATGGATATCG CACGCGGAAC AACTGGTTTCACAGGTGCCG AGCTTAGCAA CTTGGTGAAT CTGGCAGCCA TCAGGGCCGC GGTGCTGAACAAGGCGAAAG TGACCAGCGA AGAGATAGAG TACGCTAAGG ACCGCGTCAT GATGGGTGCCGAGAGCAAGA AGATTGTGCC GGAGGAGGAG CGTCGCGTGA CTGCGTTCCA CGAGGGCGGCCACGCTTTGA GCGCTATCTT GCTGAAGGAT GAGGGTGCCG ATCCTGTCCA CAAGGCAACCATTGTTCCCC GCGGCAACGG CATTATGGGA CTCGTCCAGC AACAGCCGGA CAGGGATAAGTACAGTCAAA GCAAGCGCCA GTGCCTGGCT CGCCTGAAGG TGTGTGTGGC GGGACGAGTCGGCGAAGAGA TTCTTTTAGG CCCTGACGAT ATTACCACCG GCGCAGGCTC CGATTTTCAGCAGGCCACCA ACATGGCCCG CCACATGGTG CGACAGTTCG GGTTCAGCGA CGCTATGGGCTTCGTAGACT ATGGTACACC CGACACCGCC GAAGGCGCCT ACATTTCAGA TGAGACGAAGCTCAAGATCG AAAAAGAGGT ACATCGCCTC GTTGAGCAGG CCTACATCGA GACCAAGGAGCTTCTTCTGA GCCACCGCGC CGAGTTGGAG AATATCGCCA ACAACCTGCT CAAGTATGAAACGCTCAGTG GCAAGGATCT TGAGAAGATT ATAAAGGGCG AGGCTATCCC AGAGCGTCCTCCGCGCCTGT CACAGGCTGC AGAGAGCAAG GCCGCGCCGC CACGAGGCGG GAACAGCGACCAGGCAAACG GTCGGAGAAC TGTTCCAATC TCATAG
Mitochondrial ATP-dependent zinc metallopeptidase, putative Q4Q1E9]
Metabolite Informationcell cycle; protein catabolism; proteolysis
Molecular Function
Biochemical Pathway
Regulatory Pathway
KEGG PathwaysK03798
Orthologs
Homologs GI Percent Identity Evalue Score
Homo sapiensYME1-like 1 isoform 1 [Homo sapiens]501e-126451
DEG Information
DEG Protein DEG Organism Percent Identity Evalue Bit Score
hflB ATP-dependent zinc-metallo proteaseSalmonella typhimurium42%1e-110394
Post Translational Modification
PTM Type PTM Sub Type Score Modification Site Prosite ID
PDOC00572AAA-protein family signature235-253; PS00674
PDOC00017ATP/GTP-binding site motif A (P-loop)139-146; PS00017
PDOC00595Formate--tetrahydrofolate ligase signatures68-71; PS00722
AcylationN-myristoylation site44-49; 64-69; 79-84; 103-108; 134-139; 142-147; 204-209; 302-307; 465-470; 472-477; PS00008
AmidationAmidation site204-207; 563-566; PS00009
GlycosylationN-glycosylation site68-71; PS00001
PhosphorylationcAMP- and cGMP-dependent protein kinase phosphorylation site351-354; PS00004
PhosphorylationCasein kinase II phosphorylation site52-55; 164-167; 166-169; 208-211; 301-304; 325-328; 523-526; PS00006
PhosphorylationProtein kinase C phosphorylation site100-102; 214-216; 342-344; 404-406; 504-506; 523-525; PS00005
PhosphorylationTyrosine kinase phosphorylation site119-125; 323-331; 489-495; PS00007
Mitochondrial ATP-dependent zinc metallopeptidase, putative [Q4Q1E9]
Model Information
Template PDB ID2dhrF
Percent Identity45%
Target Region93-541
Template Region150-443
Domain Information
Domains Start End
Active Site Information
Residue Active Site Number Functional Part
Co-Factor
Metal Description
Ligands
CAS number Name Mol. Weight Mol. Formula Smile Notation PDB Reference
58-64-0ADENOSINE-5'-DIPHOSPHATE427.201C10 H15 N5 O10 P2O=P(O)(O)OP(=O)(O)OCC3OC(n2cnc1c(ncnc12)N)C(O)C3O2dhr
Mutational Information
Residue Feature Description
Modeled Protein Template Structure
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/800610/Q4Q1E9.pdb 2.0 448 = residues | | = | *| Ramachandran plot: 88.0% core 9.7% allow 1.8% gener 0.5% = disall | | = | *| All Ramachandrans: 22 labelled residues (out of 446) = | +| Chi1-chi2 plots: 1 labelled residues (out of 263) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 4.0 Bad contacts: = 12 | *| Bond len/angle: 5.8 Morris et al class: 1 = 1 3 | +| 2 cis-peptides = | | G-factors Dihedrals: -0.04 Covalent: -0.18 Overall: = -0.08 | | = | | M/c bond lengths: 99.4% within limits 0.6% highlighted = | | M/c bond angles: 94.0% within limits 6.0% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further.
Overlapped Structure Procheck Summary
LeishBase: Leishmania Structural Database
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