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S-adenosylhomocysteine hydrolase [Q4Q124]
Systematic NameLmjF.36.3910 [Leishmania major]
Gene NameLMJF_36_3910
Molecular Weight47829 Da
Protein Sequence Size437
Function
Charge-3.5
Isoelectric Point5.9796 pH
DescriptionS-adenosylhomocysteine hydrolase (EC 1.16.1.8).
Subcellular LocationN.A.[Predict]
E. C. Number 1.16.1.8; 3.3.1.1
Sequence>tr|Q4Q124|Q4Q124_LEIMA S-adenosylhomocysteine hydrolase (EC 1.16.1.8) - Leishmania major
ADYKVKDISLAEWGRKAIELAENEMPGLMELRREYGPSQPLKGAKIAGCLHMTVQTAVLI
ETLKALGAELRWSSCNIFSTQDNAAAAIAKTGVPVFAWKGETDEEYEWCIAQTVKGFSGD
GLPNMILDDGGDLTNLVIDRYPELVPKIFGISEETTTGVKNLYKRLSKGNLPISAINVND
SVTKSKFDNLYGCRESLVDGIKRATDVMIAGKTCCVCGYGDVGKGCAAALRAFGARVVVT
EVDPINALQASMEGYQVALVEDVMADAHIFVTTTGNDDIITSDHFPHMRDDAIVCNIGHF
DTEIQVGWLEANAKEHVEIKPQVDRYTMENGRHIILLAKGRLVNLGCASGHPSFVMSNSF
TNQVLAQIELWSNRDNGKYPRGDKAGVFFLPKALDEKVAALHLAHVGAKLTKLTPKQAEY
INCPVNGPFKPDHYRY
DNA Sequence>LmjF36.3910 |||S-adenosylhomocysteine hydrolase|Leishmania major|chr 36|||Manual
ATGGCGGACT ACAAGGTAAA AGACATCAGC CTCGCGGAGT GGGGCCGCAA GGCGATCGAGCTCGCGGAAA ACGAGATGCC CGGTCTGATG GAGCTGCGCC GCGAGTACGG ACCCTCCCAGCCGCTGAAGG GCGCCAAGAT TGCCGGCTGC CTGCACATGA CCGTACAGAC TGCCGTGCTGATCGAGACCC TCAAGGCCCT CGGTGCGGAG CTGCGCTGGT CGTCGTGCAA CATCTTTTCCACTCAGGATA ACGCCGCTGC GGCCATTGCC AAGACTGGCG TACCGGTGTT TGCGTGGAAGGGTGAGACAG ACGAGGAGTA TGAGTGGTGC ATCGCCCAGA CAGTGAAGGG CTTCAGCGGTGACGGTCTGC CGAACATGAT CCTCGACGAC GGTGGCGACC TCACGAATCT GGTGATCGACCGCTACCCCG AGCTCGTGCC CAAGATCTTC GGTATCTCCG AGGAGACCAC GACGGGTGTGAAGAACCTGT ACAAGCGCCT GAGCAAGGGC AACCTCCCCA TCTCCGCCAT CAACGTTAACGACAGCGTGA CGAAGAGCAA GTTCGACAAC CTTTACGGCT GCCGAGAGTC CTTGGTGGACGGCATCAAGC GCGCCACGGA TGTCATGATT GCCGGCAAGA CGTGCTGCGT GTGCGGATACGGTGATGTTG GTAAGGGCTG CGCCGCCGCC CTGCGCGCCT TCGGCGCTCG CGTTGTGGTAACGGAGGTGG ACCCTATCAA TGCCCTTCAG GCCTCCATGG AGGGCTACCA GGTCGCTCTGGTCGAAGACG TCATGGCCGA TGCGCACATC TTCGTGACGA CCACCGGCAA CGATGACATCATCACCTCTG ACCACTTCCC TCACATGCGC GACGACGCCA TTGTGTGCAA CATCGGCCACTTCGACACGG AGATCCAGGT GGGATGGCTT GAGGCAAACG CCAAAGAGCA CGTGGAAATCAAGCCTCAGG TGGACCGCTA TACCATGGAG AACGGCCGTC ACATCATCCT GCTGGCTAAGGGCCGCCTGG TCAACCTCGG CTGCGCCAGC GGTCACCCGT CCTTCGTGAT GTCCAACTCCTTCACGAACC AGGTGCTGGC TCAGATCGAG CTCTGGAGCA ACCGCGACAA CGGCAAGTACCCGCGCGGTG ACAAGGCCGG CGTGTTCTTC CTGCCCAAGG CGCTCGATGA GAAGGTCGCCGCCCTCCACC TCGCCCACGT CGGCGCCAAG CTGACAAAAC TGACCCCGAA GCAGGCCGAGTACATCAACT GCCCGGTCAA CGGCCCGTTC AAGCCGGACC ACTACCGCTA CTAA
S-adenosylhomocysteine hydrolase Q4Q124]
Metabolite InformationL-serine biosynthesis; one-carbon compound metabolism
Molecular Function
Biochemical Pathway
Regulatory Pathway
KEGG PathwaysK01251
Orthologs
Homologs GI Percent Identity Evalue Score
Homo sapiensS-adenosylhomocysteine hydrolase [Homo sapiens]711e-179626
DEG Information
DEG Protein DEG Organism Percent Identity Evalue Bit Score
YER043c S-adenosyl-L-homocysteine hydrolaseSaccharomyces cerevisiae67%1e-171593
Post Translational Modification
PTM Type PTM Sub Type Score Modification Site Prosite ID
PDOC00016Cell attachment sequence382-384PS00016
PDOC00021EGF-like domain signatures and profile216-227; PS00022
PDOC00595Formate--tetrahydrofolate ligase signatures180-183; PS00722
PDOC00603S-adenosyl-L-homocysteine hydrolase signatures75-89; PS00738
PDOC00603S-adenosyl-L-homocysteine hydrolase signatures212-229; PS00739
AcylationN-myristoylation site44-49; 131-136; 193-198; 201-206; 226-231; 347-352; 408-413; PS00008
AmidationAmidation site14-17; PS00009
GlycosylationN-glycosylation site180-183; PS00001
PhosphorylationcAMP- and cGMP-dependent protein kinase phosphorylation site165-168; 203-206; PS00004
PhosphorylationCasein kinase II phosphorylation site10-13; 80-83; 103-106; 186-189; 197-200; 241-244; 275-278; 373-376; PS00006
PhosphorylationProtein kinase C phosphorylation site63-65; 114-116; 373-375; 415-417; PS00005
PhosphorylationTyrosine kinase phosphorylation site100-107; 185-192; PS00007
S-adenosylhomocysteine hydrolase [Q4Q124]
Model Information
Template PDB ID2h5lH
Percent Identity71%
Target Region1-437
Template Region2-430
Domain Information
Domains Start End
Active Site Information
Residue Active Site Number Functional Part
HIS52Sidechain
ASP130Sidechain
LYS185Sidechain
ASP189Sidechain
ASN190Sidechain
CYS194Sidechain
HIS300Sidechain
Co-Factor
Metal Description
NADBinds 1 NAD per subunit
Ligands
CAS number Name Mol. Weight Mol. Formula Smile Notation PDB Reference
2R,3R)-4-(4-AMINO-1H-IMIDAZO[4,5-C]PYRIDIN- 1-YL)-2,3-DIHYDROXYBUTANOIC ACID252.227C10 H12 N4 O4O=C(O)C(O)C(O)Cn1c2ccnc(c2nc1)N2h5l
NICOTINAMIDE-ADENINE-DINUCLEOTIDE663.425C21 H27 N7 O14 P2c1cc(c[n+](c1)C2C(C(C(O2)COP(=O)([O-])OP(=O)(O)OCC3C(C(C(O3)n4cnc5c4ncnc5N)O)O)O)O)C(=O)N2h5l
Mutational Information
Residue Feature Description
Modeled Protein Template Structure
+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/805014/Q4Q124.pdb 2.0 437 = residues | | = | +| Ramachandran plot: 95.3% core 4.5% allow 0.3% gener 0.0% = disall | | = | +| All Ramachandrans: 3 labelled residues (out of 435) = | +| Chi1-chi2 plots: 1 labelled residues (out of 252) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | *| Residue properties: Max.deviation: 3.1 Bad contacts: = 9 | *| Bond len/angle: 8.2 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.09 Covalent: -0.10 Overall: = 0.02 | | = | | M/c bond lengths: 99.3% within limits 0.7% highlighted = | *| M/c bond angles: 94.3% within limits 5.7% highlighted 1 off = graph | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further.
Overlapped Structure Procheck Summary
LeishBase: Leishmania Structural Database
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