| Phosphoribosylpyrophosphate synthetase, putative [Q4Q0M2] | |
|---|---|
| Systematic Name | LmjF.36.5390 [Leishmania major] |
| Gene Name | LMJF_36_5390 |
| Molecular Weight | 39310 Da |
| Protein Sequence Size | 358 |
| Function | |
| Charge | -4.5 |
| Isoelectric Point | 5.8 pH |
| Description | Phosphoribosylpyrophosphate synthetase, putative (EC 2.7.6.1). |
| Subcellular Location | N.A.[Predict] |
| E. C. Number | 2.7.6.1 |
| Sequence | >tr|Q4Q0M2|Q4Q0M2_LEIMA Phosphoribosylpyrophosphate synthetase, putative (EC 2.7.6.1) - Leishmania major ESCNSRNGSLRVVHGNANPKLAEDVCRYLNIPVTASRVGSFANGETIVKILESIRGDDIF VIQPTCSNSAGTNVNQAVMELLLIIHTLKLSSARRVIAVIPHYGYARQDRKHTGRVPISA SAVARMVTEMGVNGVVTMDLHCGQIQGFFHGCPVADLSPSSEFAEYVKQKNFTPNNLVVV APDAGAVNRARRMCDRIGASRIVTILKRRVVANQVDSMQLVGEVDECVCIIVDDMIDTAG TLCKAAEVLKEYGAKEVHAYATHGIFTDPACERLTQCDALVEVVVTDSIPQEESCQKCKK IKVISIAKLLADAIYRMHSEESLETVGQPEHFMPKHEDDLQVLESLVEEDEWSRCNE |
| DNA Sequence | >LmjF36.5390 |||phosphoribosylpyrophosphate synthetase, putative|Leishmania major|chr 36|||Manual ATGGAATCGT GCAACAGCCG CAACGGCTCC CTCCGCGTAG TGCACGGCAA CGCAAACCCGAAGCTCGCCG AGGACGTGTG CCGCTACCTC AACATCCCCG TCACCGCCAG CCGCGTCGGAAGCTTTGCTA ACGGGGAGAC AATTGTGAAG ATCCTCGAGT CGATCCGCGG CGATGACATCTTCGTCATTC AGCCGACCTG CAGCAACAGC GCCGGCACGA ACGTGAATCA GGCGGTGATGGAGCTGCTGC TAATCATTCA CACCCTGAAG CTGTCGTCGG CGCGCCGCGT GATTGCCGTGATTCCGCACT ACGGATACGC TCGCCAGGAC CGCAAGCACA CGGGCCGCGT GCCCATCAGCGCGTCCGCCG TGGCGCGGAT GGTGACGGAG ATGGGCGTCA ACGGCGTCGT GACAATGGACCTGCACTGCG GCCAGATTCA AGGCTTCTTC CACGGGTGCC CGGTGGCGGA CCTCAGCCCCAGCTCTGAGT TTGCCGAGTA CGTCAAACAA AAGAACTTCA CTCCGAACAA CTTGGTGGTTGTGGCACCAG ACGCCGGAGC GGTGAACCGG GCACGCCGCA TGTGTGACCG CATCGGCGCCAGTCGCATCG TCACGATTCT AAAGCGCCGC GTCGTGGCCA ACCAGGTCGA CTCAATGCAGCTGGTCGGCG AGGTCGATGA GTGTGTGTGC ATCATTGTGG ATGACATGAT CGACACGGCCGGCACGCTGT GCAAGGCGGC AGAGGTGCTG AAGGAGTACG GTGCGAAAGA AGTGCACGCCTATGCAACGC ACGGCATCTT CACCGACCCC GCGTGTGAGC GCCTCACGCA GTGCGATGCGTTGGTCGAGG TGGTGGTCAC GGATAGCATT CCACAAGAGG AGTCCTGCCA GAAGTGCAAGAAAATTAAGG TCATTTCCAT CGCAAAGCTT CTGGCCGATG CCATTTACCG CATGCACTCGGAGGAGAGTC TCGAGACGGT GGGGCAGCCG GAGCACTTCA TGCCGAAGCA TGAAGATGACCTGCAGGTAC TCGAGTCCCT TGTAGAGGAG GATGAGTGGT CACGTTGTAA CGAGTAA |
| Phosphoribosylpyrophosphate synthetase, putative Q4Q0M2] | |
|---|---|
| Metabolite Information | nucleoside metabolism; nucleotide biosynthesis; purine ribonucleotide biosynthesis |
| Molecular Function | |
| Biochemical Pathway | |
| Regulatory Pathway | |
| KEGG Pathways | K00948 |
| Orthologs | ||||
| Homologs | GI | Percent Identity | Evalue | Score |
| Homo sapiens | phosphoribosyl pyrophosphate synthetase 1 [Homo sapiens] | 40 | 5e-62 | 235 |
| DEG Information | ||||
| DEG Protein | DEG Organism | Percent Identity | Evalue | Bit Score |
| HP0742 phosphoribosylpyrophosphate synthetase (prsA) | Helicobacter pylori | 44% | 3e-69 | 256 |
| Post Translational Modification | ||||
| PTM Type | PTM Sub Type | Score | Modification Site | Prosite ID |
| PDOC00016 | Cell attachment sequence | 56-58 | PS00016 | |
| PDOC00595 | Formate--tetrahydrofolate ligase signatures | 8-11; | PS00722 | |
| PDOC00096 | Purine/pyrimidine phosphoribosyl transferases signature | 230-242; | PS00103 | |
| Acylation | N-myristoylation site | 40-45; 72-77; 144-149; 152-157; | PS00008 | |
| Glycosylation | N-glycosylation site | 8-11; | PS00001 | |
| Phosphorylation | cAMP- and cGMP-dependent protein kinase phosphorylation site | 111-114; | PS00004 | |
| Phosphorylation | Casein kinase II phosphorylation site | 276-279; 346-349; | PS00006 | |
| Phosphorylation | Protein kinase C phosphorylation site | 10-12; 54-56; 88-90; 93-95; 114-116; | PS00005 | |
| Phosphorylation | Tyrosine kinase phosphorylation site | 21-29; 309-316; | PS00007 | |
| Phosphoribosylpyrophosphate synthetase, putative [Q4Q0M2] | ||
|---|---|---|
| Model Information | ||
| Template PDB ID | 2h08B | |
| Percent Identity | 40% | |
| Target Region | 10-329 | |
| Template Region | 3-305 | |
| Domain Information | ||
|---|---|---|
| Domains | Start | End |
| Active Site Information | ||
|---|---|---|
| Residue | Active Site Number | Functional Part |
| Co-Factor | |
|---|---|
| Metal | Description |
| Ligands | |||||
|---|---|---|---|---|---|
| CAS number | Name | Mol. Weight | Mol. Formula | Smile Notation | PDB Reference |
| 14808-79-8 | SULFATE ION | 96.063 | O4 S | [O-]S([O-])(=O)=O | 2h08 |
| Mutational Information | ||
|---|---|---|
| Residue | Feature | Description |
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| Modeled Protein | Template Structure |
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+----------<<< P R O C H E C K S U M = M A R Y >>>----------+ | = | | /var/www/html/Services/SAVES_3/jobs/1545072/Q4Q0M2.pdb 2.0 320 = residues | | = | +| Ramachandran plot: 91.7% core 8.0% allow 0.3% gener 0.0% = disall | | = | +| All Ramachandrans: 7 labelled residues (out of 318) = | +| Chi1-chi2 plots: 2 labelled residues (out of 171) = | | = | | Main-chain params: 6 better 0 inside 0 worse = | | Side-chain params: 5 better 0 inside 0 worse = | | = | +| Residue properties: Max.deviation: 3.4 Bad contacts: = 3 | +| Bond len/angle: 4.7 Morris et al class: 1 = 1 2 | | = | | G-factors Dihedrals: 0.09 Covalent: -0.14 Overall: = 0.00 | | = | | M/c bond lengths: 99.2% within limits 0.8% highlighted = | | M/c bond angles: 93.8% within limits 6.2% highlighted = | | Planar groups: 100.0% within limits 0.0% highlighted = | | = | = +------------------------------------------------------------------------= ----+ + May be worth investigating further. * Worth investigating further. |