| Protein Name: | Insulin receptor substrate 2 (Q9Y4H2) |
|---|---|
| Gene Name: | IRS2 |
| Description: | Insulin receptor substrate 2 (IRS-2) |
| PDB ID: | |
| Protein Family: | |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dehydrated Alcohol | Impair Liver Regeneration | Ethanol treatment caused insulin-stimulated tyrosyl phosphorylation of the insulin receptor beta-subunit@suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression@which leads to chronic ethanol toxicity impairs liver regeneration@ inhibits DNA synthesis@ and mutes cellular responses to growth factor stimulation. [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells |
| Dehydrated Alcohol | Inhibit Dna Synthesis | Ethanol treatment caused insulin-stimulated tyrosyl phosphorylation of the insulin receptor beta-subunit@suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression@which leads to chronic ethanol toxicity impairs liver regeneration@ inhibits DNA synthesis@ and mutes cellular responses to growth factor stimulation. [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells |
| Dehydrated Alcohol | Mute Cellular Responses To Growth Factor Stimulation | Ethanol treatment caused insulin-stimulated tyrosyl phosphorylation of the insulin receptor beta-subunit@suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression@which leads to chronic ethanol toxicity impairs liver regeneration@ inhibits DNA synthesis@ and mutes cellular responses to growth factor stimulation. [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells |
This panel provides information on drug category
| Toxicity | Source |
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