| Protein Name: | SDH (Part of complex II) (P56221) |
|---|---|
| Gene Name: | SDH1 |
| Description: | |
| PDB ID: | |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Didanosine | Cytotoxicity | Increase lactate production and decrease activities of COX (complex IV) and SDH (part of complex II)@are the most potent inhibitors of mitochondrial function@thus AZT@ ddI and ddC all exert Cytotoxicity on human muscle cells and induce functional alterations of mitochondria possibly due to mechanisms other than the sole mtDNA depletion [ ADR Type 1 ] | Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells |
| Zidovudine | Cytotoxicity | Increase lactate production and decrease activities of COX (complex IV) and SDH (part of complex II)@are the most potent inhibitors of mitochondrial function@thus AZT@ ddI and ddC all exert Cytotoxicity on human muscle cells and induce functional alterations of mitochondria possibly due to mechanisms other than the sole mtDNA depletion. [ ADR Type 1 ] | Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells |
This panel provides information on drug category
| Toxicity | Source |
|---|---|
| Cytotoxicity | Cellular and mitochondrial toxicity of zidovudine (AZT), didanosine (ddI) and zalcitabine (ddC) on cultured human muscle cells |