| Protein Name: | Troponin I (P48788) |
|---|---|
| Gene Name: | TNNI2 |
| Description: | Troponin I, fast skeletal muscle (Troponin I, fast-twitch isoform) |
| PDB ID: | 2MKP |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cyclophosphamide | Cardiotoxicity | Troponins@in particular troponin I (cTnI)@ have been found to represent a uniquely sensitive and specific marker of myocyte membrane integrity and therefore to increase in response to minimal myocardial cell damage in different settings@ including doxorubicin-induced cardiotoxicity. [ ADR Type 1 ] | Serum cardiac troponin I levels and ECG/Echo monitoring in breast cancer patients undergoing high-dose (7 g/m(2)) cyclophosphamide Bone Marrow |
| Doxorubicin | Cardiotoxicity | Troponins@in particular troponin I (cTnI)@ have been found to represent a uniquely sensitive and specific marker of myocyte membrane integrity and therefore to increase in response to minimal myocardial cell damage in different settings@ including doxorubicin-INDUCED cardiotoxicity [ ADR Type 1 ] | Serum cardiac troponin I levels and ECG/Echo monitoring in breast cancer patients undergoing high-dose (7 g/m(2)) cyclophosphamide Bone Marrow |
This panel provides information on drug category
| Toxicity | Source |
|---|