| Protein Name: | G protein-activated inward rectifier potassium channel (P48549) |
|---|---|
| Gene Name: | KCNJ3 |
| Description: | G protein-activated inward rectifier potassium channel 1 (GIRK1) (Potassium channel, inwardly rectifying subfamily J member 3) (Inward rectifier K(+) channel Kir3 1) |
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This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Clonidine | Seizures | Antipsychotic drugs also inhibited the cardiac-type GIRK1/4 heteromultimeric channels@underlies the side effect of seizures. [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Clonidine | Side Effects Of Clozapine | Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes@which suggests efficacy and side effects of clozapine under clinical conditions may be partly due to activation of the delta-opioid receptor and blockade of the GIRK channel [ ADR Type 1 ] | Effects of clozapine on the delta- and kappa-opioid receptors and the G-protein-activated K+ (GIRK) channel expressed in Xenopus oocytes |
| Clonidine | Tachycardia | In oocytes co-injected with GIRK1 and GIRK2 mRNAs@ application of thioridazine immediately caused a reduction of inward currents through the basally active GIRK channels@underlies the side effect of sinus tachycardia [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Haloperidol | Seizures | In oocytes co-injected with GIRK1 and GIRK2 mRNAs@ application of thioridazine immediately caused a reduction of inward currents through the basally active GIRK channels@underlies the side effect of seizures [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Haloperidol | Sinus Tachycardia | In oocytes co-injected with GIRK1 and GIRK2 mRNAs@ application of thioridazine immediately caused a reduction of inward currents through the basally active GIRK channels@underlies the side effect of sinus tachycardia. [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Haloperidol | Tachycardia | Antipsychotic drugs also inhibited the cardiac-type GIRK1/4 heteromultimeric channels@underlies the side effect of sinus tachycardia. [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Pimozide | Seizures | Antipsychotic drugs also inhibited the cardiac-type GIRK1/4 heteromultimeric channels@underlies the side effect of seizures. [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Pimozide | Tachycardia | In oocytes co-injected with GIRK1 and GIRK2 mRNAs@ application of thioridazine immediately caused a reduction of inward currents through the basally active GIRK channels@underlies the side effect of sinus tachycardia [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Thioridazine | Seizures | Antipsychotic drugs also inhibited the cardiac-type GIRK1/4 heteromultimeric channels@underlies the side effect of seizures [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
| Thioridazine | Tachycardia | In oocytes co-injected with GIRK1 and GIRK2 mRNAs@ application of thioridazine immediately caused a reduction of inward currents through the basally active GIRK channels@underlies the side effect of sinus tachycardia [ ADR Type 1 ] | Inhibition by various antipsychotic drugs of the G-protein-activated inwardly rectifying K(+) (GIRK) channels expressed in xenopus oocytes |
This panel provides information on drug category
| Toxicity | Source |
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