| Protein Name: | Insulin receptor substrate 1 (P35568) |
|---|---|
| Gene Name: | IRS1 |
| Description: | Insulin receptor substrate 1 (IRS-1) |
| PDB ID: | 1IRS |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Dehydrated Alcohol | Impair Liver Regeneration | Ethanol treatment caused 30 to 50% reductions in the levels of tyrosyl phosphorylation of IRS-1@suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression@which leads to Chronic ethanol toxicity impairs liver regeneration@ inhibits DNA synthesis@ and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells |
| Dehydrated Alcohol | Inhibit Dna Synthesis | Ethanol treatment caused 30 to 50% reductions in the levels of tyrosyl phosphorylation of IRS-1@suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression@which leads to Chronic ethanol toxicity impairs liver regeneration@ inhibits DNA synthesis@ and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells |
| Dehydrated Alcohol | Mute Cellular Responses To Growth Factor Stimulation | Ethanol treatment caused 30 to 50% reductions in the levels of tyrosyl phosphorylation of IRS-1@suggesting that ethanol treatment substantially inhibits IRS-1 and MAP kinase signaling and growth-associated gene expression@which leads to Chronic ethanol toxicity impairs liver regeneration@ inhibits DNA synthesis@ and mutes cellular responses to growth factor stimulation [ ADR Type 1 ] | Ethanol inhibition of insulin signaling in hepatocellular carcinoma cells |
This panel provides information on drug category
| Toxicity | Source |
|---|