InAADR

Protein Information

Protein Name: Mu-Type opioid receptor (P35372)
Gene Name: OPRM1
Description:
PDB ID:
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Cyclobenzaprine Constipation Not Available Large-scale prediction and testing of drug activity on side-effect targets
Fentanyl Development Of Tolerance Fentanyl and its analogs desensitize the cloned mu opioid receptor@indicate that desensitization of the mu receptor may be a molecular basis for the development of tolerance to fentanyl and its analogs. [ ADR Type 1 ] Fentanyl and its analogs desensitize the cloned mu opioid receptor
Interferon gamma-1b Analgesia Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice@which lead to dose-dependent analgesia. [ ADR Type 1 ] Formalin-induced pain and mu-opioid receptor density in brain and spinal cord are modulated by A1 and A2a adenosine agonists in mice
Medrysone Oedema Not Available Large-scale prediction and testing of drug activity on side-effect targets
Metaraminol Insomnia Not Available Large-scale prediction and testing of drug activity on side-effect targets
Methylphenidate Dependence Not Available Large-scale prediction and testing of drug activity on side-effect targets
Morphine Cardiac Arrhythmias Morphine and morphiceptin increase the threshold for epinephrine-induced cardiac arrhythmias in the rat through brain mu opioid receptors [ ADR Type 3 ] Morphine and morphiceptin increase the threshold for epinephrine-induced cardiac arrhythmias in the rat through brain mu opioid receptors
Morphine Constipation Role of systems pharmacology in understanding drug adverse events
Pilocarpine Seizures Changes in hippocampal circuitry after pilocarpine-induced seizures@which caused a decrease in mu- and delta-opioid receptor immunoreactive (MOR-IR and DOR-IR@ respectively) neurons in the hilus and MOR-IR neurons in the granule cell layer. [ ADR Type 5 ] Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation

This panel provides information on drug category

Toxicity Source
Biliary Colic Large-scale prediction and testing of drug activity on side-effect targets
Biliary Tract Disorder Large-scale prediction and testing of drug activity on side-effect targets
Bladder Disorder Large-scale prediction and testing of drug activity on side-effect targets
Bradycardia Large-scale prediction and testing of drug activity on side-effect targets
Cerebrovascular Disorder Large-scale prediction and testing of drug activity on side-effect targets
Coma Large-scale prediction and testing of drug activity on side-effect targets
Constipation Large-scale prediction and testing of drug activity on side-effect targets
Death Large-scale prediction and testing of drug activity on side-effect targets
Dependence Large-scale prediction and testing of drug activity on side-effect targets
Dermatitis Contact Large-scale prediction and testing of drug activity on side-effect targets
Disorientation Large-scale prediction and testing of drug activity on side-effect targets
Drug Tolerance Large-scale prediction and testing of drug activity on side-effect targets
Dry Mouth Large-scale prediction and testing of drug activity on side-effect targets
Dysphoria Large-scale prediction and testing of drug activity on side-effect targets
Dysuria Large-scale prediction and testing of drug activity on side-effect targets
Euphoric Mood Large-scale prediction and testing of drug activity on side-effect targets
Hyperhidrosis Large-scale prediction and testing of drug activity on side-effect targets
Hypothermia Large-scale prediction and testing of drug activity on side-effect targets
Injection Site Irritation Large-scale prediction and testing of drug activity on side-effect targets
Injection Site Pain Large-scale prediction and testing of drug activity on side-effect targets
Intracranial Pressure Increased Large-scale prediction and testing of drug activity on side-effect targets
Mental Disorder Large-scale prediction and testing of drug activity on side-effect targets
Miosis Large-scale prediction and testing of drug activity on side-effect targets
Mood Altered Large-scale prediction and testing of drug activity on side-effect targets
Muscle Rigidity Large-scale prediction and testing of drug activity on side-effect targets
Muscle Spasms Large-scale prediction and testing of drug activity on side-effect targets
Oliguria Large-scale prediction and testing of drug activity on side-effect targets
Orthostatic Hypotension Large-scale prediction and testing of drug activity on side-effect targets
Pruritus Large-scale prediction and testing of drug activity on side-effect targets
Respiratory Depression Large-scale prediction and testing of drug activity on side-effect targets
Respiratory Disorder Large-scale prediction and testing of drug activity on side-effect targets
Restlessness Large-scale prediction and testing of drug activity on side-effect targets
Shock Large-scale prediction and testing of drug activity on side-effect targets
Somnolence Large-scale prediction and testing of drug activity on side-effect targets
Ureteral Spasm Large-scale prediction and testing of drug activity on side-effect targets
Urticaria Large-scale prediction and testing of drug activity on side-effect targets
Withdrawal Syndrome Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database