InAADR

Protein Information

Protein Name: Histamine H1 receptor (P35367)
Gene Name: HRH1
Description:
PDB ID: 3RZE
Protein Family: PF00001, PS00237
Protein Category: Membrane Receptors

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Aprindine Agranulocytosis Not Available Large-scale prediction and testing of drug activity on side-effect targets
Aprindine Bone Marrow Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Aprindine Extrapyramidal Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Azatadine Dry Mouth Not Available Large-scale prediction and testing of drug activity on side-effect targets
Benzquinamide Somnolence Not Available Large-scale prediction and testing of drug activity on side-effect targets
Chlorotrianisene Abdominal Pain Not Available Large-scale prediction and testing of drug activity on side-effect targets
Chlorotrianisene Rash Not Available Large-scale prediction and testing of drug activity on side-effect targets
cinnarizine Somnolence Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clemastine Constipation Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clemastine Dry Mouth Not Available Large-scale prediction and testing of drug activity on side-effect targets
Clemastine Insomnia Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Convulsion Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Dry Mouth Not Available Large-scale prediction and testing of drug activity on side-effect targets
Gabapentin Anxiety Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to anxiety [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Nausea Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to nausea [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Gabapentin Sleep Disturbances Significant adverse effects may occur through the interaction of the antidepressants with other receptors believed not to be related to the therapeutic action@ most importantly the muscarinic acetylcholine receptor (M)@ the histamine-1 (H1) receptor and the alpha-1 (alpha 1) adrenergic receptor@leading to sleep disturbances. [ ADR Type 2 ] Cell-mediated side effects of psychopharmacological treatment
Isopropamide Tachycardia Not Available Large-scale prediction and testing of drug activity on side-effect targets
Methylphenidate Dysuria Not Available Large-scale prediction and testing of drug activity on side-effect targets
Methylphenidate Euphoric Mood Not Available Large-scale prediction and testing of drug activity on side-effect targets
Methylphenidate Hyperhidrosis Not Available Large-scale prediction and testing of drug activity on side-effect targets
Methylphenidate Restlessness Not Available Large-scale prediction and testing of drug activity on side-effect targets
Methylprednisolone Depression Not Available Large-scale prediction and testing of drug activity on side-effect targets
Methylprednisolone Oedema Not Available Large-scale prediction and testing of drug activity on side-effect targets
Oxamniquine Electrocardiogram Change Not Available Large-scale prediction and testing of drug activity on side-effect targets
Pimozide Ventricular Arrhythmia Not Available Large-scale prediction and testing of drug activity on side-effect targets

This panel provides information on drug category

Toxicity Source
Agranulocytosis Large-scale prediction and testing of drug activity on side-effect targets
Akathisia Large-scale prediction and testing of drug activity on side-effect targets
Anticholinergic Syndrome Large-scale prediction and testing of drug activity on side-effect targets
Ataxia Large-scale prediction and testing of drug activity on side-effect targets
Bladder Disorder Large-scale prediction and testing of drug activity on side-effect targets
Bone Marrow Disorder Large-scale prediction and testing of drug activity on side-effect targets
Central Nervous System Stimulation Large-scale prediction and testing of drug activity on side-effect targets
Chest Discomfort Large-scale prediction and testing of drug activity on side-effect targets
Conduction Disorder Large-scale prediction and testing of drug activity on side-effect targets
Constipation Large-scale prediction and testing of drug activity on side-effect targets
Convulsion Large-scale prediction and testing of drug activity on side-effect targets
Cycloplegia Large-scale prediction and testing of drug activity on side-effect targets
Dermatitis Allergic Large-scale prediction and testing of drug activity on side-effect targets
Diabetic Eye Disease Large-scale prediction and testing of drug activity on side-effect targets
Dry Mouth Large-scale prediction and testing of drug activity on side-effect targets
Dystonia Large-scale prediction and testing of drug activity on side-effect targets
Dysuria Large-scale prediction and testing of drug activity on side-effect targets
Euphoric Mood Large-scale prediction and testing of drug activity on side-effect targets
Extrapyramidal Disorder Large-scale prediction and testing of drug activity on side-effect targets
Galactorrhoea Large-scale prediction and testing of drug activity on side-effect targets
Haemolytic Anaemia Large-scale prediction and testing of drug activity on side-effect targets
Hypercholesterolaemia Large-scale prediction and testing of drug activity on side-effect targets
Hyperthermia Large-scale prediction and testing of drug activity on side-effect targets
Hyporeflexia Large-scale prediction and testing of drug activity on side-effect targets
Increased Appetite Large-scale prediction and testing of drug activity on side-effect targets
Increased Viscosity Of Bronchial Secretion Large-scale prediction and testing of drug activity on side-effect targets
Insomnia Large-scale prediction and testing of drug activity on side-effect targets
Muscular Weakness Large-scale prediction and testing of drug activity on side-effect targets
Myopathy Large-scale prediction and testing of drug activity on side-effect targets
Nervousness Large-scale prediction and testing of drug activity on side-effect targets
Parkinsonism Large-scale prediction and testing of drug activity on side-effect targets
Photosensitivity Reaction Large-scale prediction and testing of drug activity on side-effect targets
Sedation Large-scale prediction and testing of drug activity on side-effect targets
Skin Sensitisation Large-scale prediction and testing of drug activity on side-effect targets
Somnolence Large-scale prediction and testing of drug activity on side-effect targets
Tachycardia Large-scale prediction and testing of drug activity on side-effect targets
Tardive Dyskinesia Large-scale prediction and testing of drug activity on side-effect targets
Tinnitus Large-scale prediction and testing of drug activity on side-effect targets
Tremor Large-scale prediction and testing of drug activity on side-effect targets
Urinary Retention Large-scale prediction and testing of drug activity on side-effect targets
Urinary Tract Disorder Large-scale prediction and testing of drug activity on side-effect targets
Vision Blurred Large-scale prediction and testing of drug activity on side-effect targets
Weight Increased Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database