| Protein Name: | BCL oncogene (P24385) |
|---|---|
| Gene Name: | CCND1 |
| Description: | G1/S-specific cyclin-D1 (PRAD1 oncogene) (BCL-1 oncogene) |
| PDB ID: | 2W96 |
| Protein Family: | |
| Protein Category: | Cytosolic Protein | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Indomethacin | Arrests Endothelial Cell Proliferation | Indomethacin significantly inhibited basal and bFGF-stimulated endothelial cell proliferation@which is correlated significantly with reduced cyclin D1 and increased p21 protein expression@suggestting that indomethacin arrests endothelial cell proliferation essential for angiogenesis by modulating cell cycle protein levels [ ADR Type 2 ] | Indomethacin inhibits endothelial cell proliferation by suppressing cell cycle proteins and PRB phosphorylation: a key to its antiangiogenic action? |
| Mitoxantrone | Apoptosis | Intracellularly@ mitoxantrone-induced programmed cell death (PCD) was associated with a marked induction of c-jun and significant repression of c-myc and BCL-2 oncogenes [ ADR Type 3 ] | High-dose mitoxantrone induces programmed cell death or apoptosis in human myeloid leukemia cells |
This panel provides information on drug category
| Toxicity | Source |
|---|