| Protein Name: | Acetylcholinesterase precursor (P22303) |
|---|---|
| Gene Name: | ACHE |
| Description: | |
| PDB ID: | 1B41 |
| Protein Family: | PF08674, PS00122 |
| Protein Category: | Enzyme |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Indomethacin | Enhance Contractility Of The Small Intestine | Treatment of the rat with indomethacin decreased responsiveness of enteric neurons with the progression of lesions owing to diminution of acetylcholinesterase activity [ ADR Type 3 ] | Indomethacin-induced lesion modifies contractile activity in rat small intestines Scand |
| Physostigmine | Nausea | The incidence of nausea at cognitively effective dosages ranges from 1% with eptastigmine 60 mg/day to 53% with physostigmine 30 mg/day@Differences in tolerability profile may be due to the extent of peripheral acetylcholinesterase inhibition needed to reach clinical efficacy [ ADR Type 1 ] | Pharmacodynamic-tolerability relationships of cholinesterase inhibitors for Alzheimer's disease |
This panel provides information on drug category