| Protein Name: | Vinculin (P18206) |
|---|---|
| Gene Name: | VCL |
| Description: | Vinculin (Metavinculin) |
| PDB ID: | 1RKC |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Estradiol | Cells To Form Multilayers | Because estradiol induces changes in both cell-matrix and cell-cell adhesions in an estrogen-responsive carcinoma cell line@the gradual loss of Vinculin from cell-matrix and cell-cell adherens junctions of the monolayer could be a potential factor in the capacity of these cells to form multilayers or nodules in postconfluent growth [ ADR Type 2 ] | 17-beta-Estradiol induced alterations of cell-matrix and intercellular adhesions in a human mammary carcinoma cell line |
| Phylloquinone | Morphological Changes | Different behavioural characteristics of actin microfilaments@ vimentin and keratin intermediate filaments and microtubules was observed@which demonstrate that cytoskeletal structures and the microfilament system in particular@represent important targets in menadione-induced morphological changes in cultured cells [ ADR Type 2 ] | Cytoskeleton as a target in menadione-induced oxidative stress in cultured mammalian cells: alterations underlying surface bleb formation |
This panel provides information on drug category
| Toxicity | Source |
|---|