InAADR

Protein Information

Protein Name: Glucocorticoid receptor (P04150)
Gene Name: NR3C1
Description:
PDB ID: 1M2Z
Protein Family: PF02155, PS00031
Protein Category: Transcription Factor

This panel provides drug-protein interaction and their ADRs along with references

Interacting Drugs Toxicity Mechanism Reference
Cyclobenzaprine Bladder Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Urinary Retention Not Available Large-scale prediction and testing of drug activity on side-effect targets
Cyclobenzaprine Vision Blurred Not Available Large-scale prediction and testing of drug activity on side-effect targets
Diperodon Death Not Available Large-scale prediction and testing of drug activity on side-effect targets
Diperodon Respiratory Disorder Not Available Large-scale prediction and testing of drug activity on side-effect targets
Diperodon Restlessness Not Available Large-scale prediction and testing of drug activity on side-effect targets
Diperodon Somnolence Not Available Large-scale prediction and testing of drug activity on side-effect targets
Estradiol Glucocorticoid Resistance Estradiol inhibits glucocorticoid receptor expression and induces glucocorticoid resistance in MCF-7 human breast cancer cells. [ ADR Type 1 ] Estradiol inhibits glucocorticoid receptor expression and induces glucocorticoid resistance in MCF-7 human breast cancer cells
glucocorticoid Cleft Palate Susceptibility to glucocorticoid- and phenytoin-induced cleft palate and glucocorticoid receptor levels in mice are influenced by the H-2 histocompatibility complex on chromosome 17 [ ADR Type 3 ] H-2 influences phenytoin binding and inhibition of prostaglandin synthesis
Methylprednisolone Liver Toxicity Dose dependence and tolerance effects of TAT mRNA/TAT induction by MPL involving multiple-step signal transduction controlled by the steroid regimen,which may lead to liver toxicity [ ADR Type 1 ] Dose-dependence and repeated-dose studies for receptor/gene-mediated pharmacodynamics of methylprednisolone on glucocorticoid receptor down-regulation and tyrosine aminotransferase induction in rat liver

This panel provides information on drug category

Toxicity Source
Acne Large-scale prediction and testing of drug activity on side-effect targets
Adrenal Disorder Large-scale prediction and testing of drug activity on side-effect targets
Adrenal Insufficiency Large-scale prediction and testing of drug activity on side-effect targets
Adrenal Suppression Large-scale prediction and testing of drug activity on side-effect targets
Amenorrhoea Large-scale prediction and testing of drug activity on side-effect targets
Bone Disorder Large-scale prediction and testing of drug activity on side-effect targets
Calcium Metabolism Disorder Large-scale prediction and testing of drug activity on side-effect targets
Cataract Large-scale prediction and testing of drug activity on side-effect targets
Cushingoid Large-scale prediction and testing of drug activity on side-effect targets
Depression Large-scale prediction and testing of drug activity on side-effect targets
Dysphonia Large-scale prediction and testing of drug activity on side-effect targets
Embolism Arterial Large-scale prediction and testing of drug activity on side-effect targets
Endocrine Disorder Large-scale prediction and testing of drug activity on side-effect targets
Epidural Lipomatosis Large-scale prediction and testing of drug activity on side-effect targets
Epistaxis Large-scale prediction and testing of drug activity on side-effect targets
Euphoric Mood Large-scale prediction and testing of drug activity on side-effect targets
Fluid Retention Large-scale prediction and testing of drug activity on side-effect targets
Foot And Mouth Disease Large-scale prediction and testing of drug activity on side-effect targets
Fracture Large-scale prediction and testing of drug activity on side-effect targets
Fungal Infection Large-scale prediction and testing of drug activity on side-effect targets
Glaucoma Large-scale prediction and testing of drug activity on side-effect targets
Growth Retardation Large-scale prediction and testing of drug activity on side-effect targets
Hyperglycaemia Large-scale prediction and testing of drug activity on side-effect targets
Hypertension Large-scale prediction and testing of drug activity on side-effect targets
Hypertrichosis Large-scale prediction and testing of drug activity on side-effect targets
Hypokalaemia Large-scale prediction and testing of drug activity on side-effect targets
Impaired Healing Large-scale prediction and testing of drug activity on side-effect targets
Increased Appetite Large-scale prediction and testing of drug activity on side-effect targets
Intracranial Pressure Increased Large-scale prediction and testing of drug activity on side-effect targets
Menstrual Disorder Large-scale prediction and testing of drug activity on side-effect targets
Muscular Weakness Large-scale prediction and testing of drug activity on side-effect targets
Nitrogen Balance Negative Large-scale prediction and testing of drug activity on side-effect targets
Oedema Large-scale prediction and testing of drug activity on side-effect targets
Oral Candidiasis Large-scale prediction and testing of drug activity on side-effect targets
Osteonecrosis Large-scale prediction and testing of drug activity on side-effect targets
Osteoporosis Large-scale prediction and testing of drug activity on side-effect targets
Pancreatic Disorder Large-scale prediction and testing of drug activity on side-effect targets
Pancreatitis Acute Large-scale prediction and testing of drug activity on side-effect targets
Peptic Ulcer Large-scale prediction and testing of drug activity on side-effect targets
Phosphorus Metabolism Disorder Large-scale prediction and testing of drug activity on side-effect targets
Sepsis Large-scale prediction and testing of drug activity on side-effect targets
Skin Atrophy Large-scale prediction and testing of drug activity on side-effect targets
Skin Striae Large-scale prediction and testing of drug activity on side-effect targets
Superinfection Large-scale prediction and testing of drug activity on side-effect targets
Telangiectasia Large-scale prediction and testing of drug activity on side-effect targets

InAADR: Drug-Protein-ADRs database