| Protein Name: | Interferon gamma (P01579) |
|---|---|
| Gene Name: | IFNG |
| Description: | Interferon gamma precursor (IFN-gamma) (Immune interferon) |
| PDB ID: | 1EKU |
| Protein Family: | |
| Protein Category: | Secreted Protein |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Amphotericin B | Neurotoxicity | Amphotericin B caused a dose-dependent increase of NO generation in interferon-gamma (IFN-gamma)-stimulated rat and mouse astrocytes, as well as in IFN-gamma + tumor necrosis factor-alpha (TNF-alpha)-activated rat astrocytoma cell line C6,which might be at least partly responsible for AMB neurotoxicity. [ ADR Type 1 ] | Amphotericin B potentiates the activation of inducible nitric oxide synthase and causes nitric oxide-dependent mitochondrial dysfunction in cytokine-treated rodent |
This panel provides information on drug category
| Toxicity | Source |
|---|