| Protein Name: | Tumor necrosis factor receptor superfamily member 10B (O14763) |
|---|---|
| Gene Name: | TNFRSF10B |
| Description: | Tumor necrosis factor receptor superfamily member 10B precursor (Death receptor 5) (TNF-related apoptosis-inducing ligand receptor 2) (TRAIL receptor 2) (TRAIL-R2) (CD262 antigen) |
| PDB ID: | 1D0G |
| Protein Family: | |
| Protein Category: |
This panel provides drug-protein interaction and their ADRs along with references
| Interacting Drugs | Toxicity | Mechanism | Reference |
|---|---|---|---|
| Cisplatin | Tumor Response | Eleven (32%) and 14 (41%) advanced non-small-cell lung cancer (NSCLC) cases were found positive for DR5 and Bcl-2, respectively,The response rate was significantly higher in patients with DR5 expression.Therefore,Death receptor 5 and Bcl-2 protein expression is as predictors of tumor response. [ ADR Type 2 ] | Death receptor 5 and Bcl-2 protein expression as predictors of tumor response to gemcitabine and cisplatin in patients with advanced non-small-cell lung cancer |
| Gemcitabine | Tumor Response | Eleven (32%) and 14 (41%) advanced non-small-cell lung cancer (NSCLC) cases were found positive for DR5 and Bcl-2, respectively,The response rate was significantly higher in patients with DR5 expression,therefore,Death receptor 5 and Bcl-2 protein expression is as predictors of tumor response. [ ADR Type 2 ] | Death receptor 5 and Bcl-2 protein expression as predictors of tumor response to gemcitabine and cisplatin in patients with advanced non-small-cell lung cancer |
This panel provides information on drug category
| Toxicity | Source |
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