InAADR

Drug Information

Drug Name: Glyburide (10238-21-8)
PubChem ID: 3488
SMILES: COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3
InchiKey: ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Therapeutic Category: Hypoglycemic Agents

Computed Drug Properties

Molecular Weight (dalton): 494.013
LogP: 3.6417
Ring Count: 2
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 3
Total Polar Surface Area: 113.6

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Haemolysis Glucose-6-phosphate 1-dehydrogenase (P11413) Glyburide-induced acute haemolysis in a glucose-6-phosphate dehydrogenase (G6PD) -deficient patient [ ADR Type 2 3 ] Glyburide-induced acute haemolysis in a G6PD-deficient patient with NIDDM
Obesity-Prone sulfonylurea receptors (Q09429) Glucose may affect the firing of glucose-responsive neurons by indirectly altering KATP channel function via its effects on low-affinity cell body SUR. [ ADR Type 2 ] In vivo and in vitro regulation of [3H]glyburide binding to brain sulfonylurea receptors in obesity-prone and resistant rats by glucose

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abasia MetaADEDB
Abdominal Distension ADReCS
Abdominal Pain ADReCS
Abscess MetaADEDB
Accommodation Disorder ADReCS
Acetonaemia MetaADEDB
Acid Reflux MetaADEDB
Acidosis MetaADEDB
Acidosis Lactic MetaADEDB
Actinomycosis MetaADEDB
Acute Coronary Syndrome MetaADEDB
Acute Kidney Failure MetaADEDB
Acute Myocardial Infarction MetaADEDB
Adjustment Disorder With Depressed Mood MetaADEDB
Adverse Event MetaADEDB
Adynamic Ileus MetaADEDB
Affective Disorder MetaADEDB
Afib MetaADEDB
Ageusia MetaADEDB
Agranulocytosis ADReCS
Alanine Aminotransferase Increased MetaADEDB
Alcohol Intolerance ADReCS
Alkalosis Hypochloraemic MetaADEDB
Allergic Cutaneous Angiitis SIDER
Allergic Reaction ADReCS
Allergic Skin Reaction ADReCS
Allergies MetaADEDB
Alveoloplasty MetaADEDB
Anaemia ADReCS
Anemia Hemolytic MetaADEDB
Angina MetaADEDB
Angina Unstable MetaADEDB
Angioedema ADReCS
Anorexia MetaADEDB
Anorgasmia MetaADEDB
Anti-Hbe Antibody Positive MetaADEDB
Antibiotic Level Above Therapeutic MetaADEDB
Anticonvulsant Drug Level Decreased MetaADEDB
Aortic Arteriosclerosis MetaADEDB
Aortic Stenosis MetaADEDB
Aortic Valve Calcification MetaADEDB
Apathy MetaADEDB
Aplastic Anaemia ADReCS
Apoplexy MetaADEDB
Appendicitis Perforated MetaADEDB
Application Site Erythema MetaADEDB
Application Site Scar MetaADEDB
Arrhythmias Cardiac MetaADEDB
Arterial Occlusive Disease MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arterial Restenosis MetaADEDB
Arteriosclerosis Coronary Artery MetaADEDB
Arteriosclerotic Heart Disease MetaADEDB
Arteritis MetaADEDB
Arthralgia ADReCS
Aseptic Meningitis MetaADEDB
Aspartate Aminotransferase Increase MetaADEDB
Asthenia ADReCS
Asthma MetaADEDB
Asthmatic Crisis MetaADEDB
Asystole MetaADEDB
Atelectasis MetaADEDB
Atherosclerosis MetaADEDB
Atrioventricular Block MetaADEDB
Atrioventricular Block Complete MetaADEDB
Attempted Suicide MetaADEDB
Back Ache MetaADEDB
Back Injury MetaADEDB
Bacterial Infection MetaADEDB
Bacterial Pneumonia MetaADEDB
Bacterial Vaginitis MetaADEDB
Balanitis MetaADEDB
Belching MetaADEDB
Benign Prostatic Hyperplasia MetaADEDB
Bilirubin Conjugated Increased MetaADEDB
Biopsy Bone Marrow Abnormal MetaADEDB
Bipolar Disorder MetaADEDB
Blister MetaADEDB
Blood Albumin Decreased MetaADEDB
Blood Alkaline Phosphatase Increased MetaADEDB
Blood Antidiuretic Hormone Abnormal ADReCS
Blood Antidiuretic Hormone Increased ADReCS
Blood Bilirubin Increased MetaADEDB
Blood Cholesterol MetaADEDB
Blood Creatinine MetaADEDB
Blood Creatinine Increased MetaADEDB
Blood Glucose Abnormal MetaADEDB
Blood Glucose Decreased MetaADEDB
Blood In Urine MetaADEDB
Blood Lactate Dehydrogenase Increased MetaADEDB
Blood Magnesium Decreased MetaADEDB
Blood Potassium Increased MetaADEDB
Blood Pressure Abnormal MetaADEDB
Blood Sodium MetaADEDB
Blood Triglycerides Increased MetaADEDB
Blood Urea Increased MetaADEDB
Bloody Discharge MetaADEDB
Body Temperature Increased MetaADEDB
Bone Disorder MetaADEDB
Bone Inflammation MetaADEDB
Bone Marrow Transplant MetaADEDB
Bradypnoea MetaADEDB
Bronchiectasis MetaADEDB
Bronchitis MetaADEDB
Bundle Branch Block Left MetaADEDB
Bundle Branch Block Right MetaADEDB
Calculus Ureteric MetaADEDB
Carcinoma Of The Colon MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiac Enlargement MetaADEDB
Cardiac Failure MetaADEDB
Cardiac Ischemia MetaADEDB
Cardiac Stress Test MetaADEDB
Cardio-Respiratory Arrest MetaADEDB
Cardioactive Drug Level MetaADEDB
Carotid Artery Dissection MetaADEDB
Carotid Artery Occlusion MetaADEDB
Carotid Artery Stenosis MetaADEDB
Cartilage Development Disorder MetaADEDB
Cataract MetaADEDB
Catheter Site Cellulitis MetaADEDB
Catheterisation Cardiac MetaADEDB
Cellulitis MetaADEDB
Central Nervous System Disorder SIDER
Cerebral Infarct MetaADEDB
Chest Pain MetaADEDB
Chest Tube Insertion MetaADEDB
Chill MetaADEDB
Choking Sensation MetaADEDB
Cholangiolitis MetaADEDB
Cholangitis Acute MetaADEDB
Cholecystitis Chronic MetaADEDB
Cholelithiasis MetaADEDB
Cholestasis ADReCS
Cholestasis Intrahepatic MetaADEDB
Chorioretinal Disorder MetaADEDB
Chronic Obstructive Airway Disease MetaADEDB
Clostridium Difficile Colitis MetaADEDB
Cluster Headache MetaADEDB
Colorectal Cancer MetaADEDB
Colorectal Cancer Stage Iii MetaADEDB
Coma ADReCS
Concomitant Disease Progression MetaADEDB
Condition Aggravated MetaADEDB
Confabulation MetaADEDB
Congenital Tricuspid Valve Incompetence MetaADEDB
Congestive Cardiomyopathy MetaADEDB
Conjunctivitis Infective MetaADEDB
Constipated MetaADEDB
Convulsion ADReCS
Corneal Ulcer MetaADEDB
Coronary Artery Disease MetaADEDB
Coronary Artery Occlusion MetaADEDB
Coronary Artery Restenosis MetaADEDB
Coronary Artery Stenosis MetaADEDB
Costochondritis MetaADEDB
Cough MetaADEDB
Coughing Blood MetaADEDB
Debridement MetaADEDB
Dehydration MetaADEDB
Dementia Alzheimer Type MetaADEDB
Dental Caries MetaADEDB
Depression Postoperative MetaADEDB
Dermatitis ADReCS
Dermatitis Medicamentosa MetaADEDB
Device Occlusion MetaADEDB
Diabetes MetaADEDB
Diabetes Complications MetaADEDB
Diabetes Mellitus MetaADEDB
Diabetes Mellitus Inadequate Control ADReCS
Diabetes Mellitus Insulin-Dependent MetaADEDB
Diabetes Mellitus Non-Insulin-Dependent MetaADEDB
Diabetes Mellitus Type 2 MetaADEDB
Diabetic Acidosis MetaADEDB
Diabetic Foot MetaADEDB
Diabetic Nephropathy MetaADEDB
Diabetic Neuropathy MetaADEDB
Diabetic Retinopathy MetaADEDB
Diabetic Vascular Disorder MetaADEDB
Diarrhea MetaADEDB
Diarrhoea ADReCS
Difficulty In Walking MetaADEDB
Dilatation Atrial MetaADEDB
Diplopia MetaADEDB
Disorder Of Globe MetaADEDB
Drowsiness MetaADEDB
Drug Effect Decreased MetaADEDB
Drug Hypersensitivity MetaADEDB
Drug Interaction MetaADEDB
Drug Toxicity MetaADEDB
Drug-Induced Liver Injury MetaADEDB
Duodenal Ulcer MetaADEDB
Dyspepsia ADReCS
Dysphonia MetaADEDB
Dysphoria MetaADEDB
Dyspnoea ADReCS
Dysstasia MetaADEDB
Edema Extremities MetaADEDB
Ejection Fraction Abnormal MetaADEDB
Electrocardiogram T Wave Amplitude Decreased MetaADEDB
Emesis MetaADEDB
Emotional Distress MetaADEDB
Encephalitis Allergic MetaADEDB
Encephalopathy MetaADEDB
Endocarditis MetaADEDB
Endotoxemia MetaADEDB
Enlarged Spleen MetaADEDB
Enterococcal Infection MetaADEDB
Eosinophilia MetaADEDB
Epigastric Fullness SIDER
Erectile Dysfunction MetaADEDB
Eruption SIDER
Erythema ADReCS
Erythema Induratum MetaADEDB
Erythropenia ADReCS
Exanthema MetaADEDB
Excess Potassium MetaADEDB
Excoriation MetaADEDB
Exercise Tolerance Decreased MetaADEDB
Extremity Contracture MetaADEDB
Extremity Pain MetaADEDB
Face Pain MetaADEDB
Facial Neuralgia MetaADEDB
Faecaloma MetaADEDB
Faeces Discoloured MetaADEDB
Failure To Thrive MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue MetaADEDB
Fatty Liver MetaADEDB
Feeling Cold MetaADEDB
Gall Bladder MetaADEDB
Ganglion MetaADEDB
Gastric Cancer MetaADEDB
Gastroenteritis Viral MetaADEDB
Gastrointestinal Bleed MetaADEDB
Gastrointestinal Disorder ADReCS
Gastrointestinal Pain ADReCS
Gastrointestinal Ulcer MetaADEDB
Glaucoma MetaADEDB
Glycosylated Haemoglobin Increased MetaADEDB
Goiter MetaADEDB
Granulomatous Liver Disease MetaADEDB
Haematochezia MetaADEDB
Haemolytic Anaemia ADReCS
Heart Attack MetaADEDB
Heartburn ADReCS
Hemiparesis MetaADEDB
Hepatic Enzyme MetaADEDB
Hepatic Failure ADReCS
Hepatic Function Abnormal ADReCS
Hepatic Impairment ADReCS
Hepatic Neoplasia MetaADEDB
Hepatitis ADReCS
Herpes Zoster MetaADEDB
Hoarseness MetaADEDB
Hot Flash MetaADEDB
Hyperalgesia MetaADEDB
Hyperemia MetaADEDB
Hypersensitivity ADReCS
Hypertension MetaADEDB
Hypertension Portal MetaADEDB
Hypoglycaemia Neonatal MetaADEDB
Hypoglycemia MetaADEDB
Hyponatraemia ADReCS
Hypopituitarism ADReCS
Hypotension ADReCS
Hypothyroid MetaADEDB
Ild MetaADEDB
Iliac Artery Occlusion MetaADEDB
Implantable Defibrillator Insertion MetaADEDB
Inappropriate Antidiuretic Hormone Secretion ADReCS
Incision Site Complication MetaADEDB
Incision Site Haemorrhage MetaADEDB
Infection ADReCS
Infection Upper Respiratory MetaADEDB
Injection Site Induration MetaADEDB
Injection Site Urticaria MetaADEDB
Injection Site Vesicles MetaADEDB
Injury ADReCS
Insulin-Requiring Type 2 Diabetes Mellitus MetaADEDB
International Normalised Ratio Decreased MetaADEDB
Intervertebral Disc Disorder MetaADEDB
Intervertebral Disc Operation MetaADEDB
Intestinal Operation MetaADEDB
Iron Deficiency Anaemia MetaADEDB
Ischaemic Cardiomyopathy MetaADEDB
Jaundice ADReCS
Jaundice Cholestatic ADReCS
Jaw Operation MetaADEDB
Joint Contracture MetaADEDB
Joint Effusion MetaADEDB
Kidney Diseases MetaADEDB
Klebsiella Infection MetaADEDB
Lacunar Infarction MetaADEDB
Lateral Medullary Syndrome MetaADEDB
Left Ventricular End-Diastolic Pressure Increased MetaADEDB
Lethargy MetaADEDB
Leukocytoclastic Vasculitis ADReCS
Leukopenia ADReCS
Lipase MetaADEDB
Liver Disorder ADReCS
Liver Failure MetaADEDB
Localised Infection MetaADEDB
Long Qt Syndrome MetaADEDB
Loss Of Weight MetaADEDB
Lumbar Vertebral Fracture MetaADEDB
Lung Adenocarcinoma Metastatic MetaADEDB
Lung Cancer Metastatic MetaADEDB
Lung Infiltration MetaADEDB
Lymphocyte Stimulation Test Positive MetaADEDB
Lymphoma MetaADEDB
Malignant Hypertension MetaADEDB
Malignant Neoplasm Progression MetaADEDB
Mallory-Weiss Syndrome MetaADEDB
Malnutrition ADReCS
Markedly Reduced Dietary Intake MetaADEDB
Mean Cell Haemoglobin MetaADEDB
Mean Cell Volume Increased MetaADEDB
Meningitis Bacterial MetaADEDB
Mental Status Changes MetaADEDB
Metabolic Encephalopathy MetaADEDB
Middle Ear Inflammation MetaADEDB
Miosis MetaADEDB
Monocyte Percentage Decreased MetaADEDB
Mononeuritis MetaADEDB
Mouth Pain MetaADEDB
Multiple Myeloma MetaADEDB
Multiple System Atrophy MetaADEDB
Muscle Graft MetaADEDB
Muscle Strain MetaADEDB
Musculoskeletal Chest Pain MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Disorder MetaADEDB
Myalgia ADReCS
Mycobacterium Marinum Infection MetaADEDB
Mycobacterium Tuberculosis Infection MetaADEDB
Mycosis Fungoides MetaADEDB
Myelodysplasia MetaADEDB
Myelosuppression SIDER
Myocardial Ischemia MetaADEDB
Myoclonic Epilepsy MetaADEDB
Nasal Dryness MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Necrosis MetaADEDB
Neoplasm Prostate MetaADEDB
Nephritis Interstitial MetaADEDB
Nephropathy ADReCS
Nerve Injury ADReCS
Nervous System Disorder SIDER
Neumonia MetaADEDB
Neuropathy Peripheral MetaADEDB
Neurotoxicity Syndromes MetaADEDB
Nocturia MetaADEDB
Nodule On Extremity MetaADEDB
Normochromic Normocytic Anaemia MetaADEDB
Obstructive Airways Disorder MetaADEDB
Oculomucocutaneous Syndrome MetaADEDB
Ornithine Transcarbamoylase Deficiency MetaADEDB
Osteosclerosis MetaADEDB
Pain ADReCS
Pain Of Skin MetaADEDB
Pallor MetaADEDB
Palmar-Plantar Erythrodysaesthesia Syndrome MetaADEDB
Pancreatic Pseudocyst MetaADEDB
Pancreatitis MetaADEDB
Pancytopenia ADReCS
Pericardial Effusion MetaADEDB
Periodontitis MetaADEDB
Peripheral Sensory Neuropathy MetaADEDB
Phlebitis MetaADEDB
Photosensitivity SIDER
Photosensitivity Reaction ADReCS
Pinguecula MetaADEDB
Pitting Oedema MetaADEDB
Plasmacytoma MetaADEDB
Platelet Count MetaADEDB
Pleural Effusion MetaADEDB
Polycythaemia MetaADEDB
Polyuria MetaADEDB
Poor Peripheral Circulation MetaADEDB
Porphyria ADReCS
Porphyria Cutanea Tarda SIDER
Porphyria Hepatic SIDER
Porphyria Non-Acute ADReCS
Post Herpetic Neuralgia MetaADEDB
Post Lumbar Puncture Syndrome MetaADEDB
Post Traumatic Stress Disorder MetaADEDB
Postoperative Wound Complication MetaADEDB
Prescribed Overdose MetaADEDB
Procedural Pain MetaADEDB
Prostatitis MetaADEDB
Proteinuria MetaADEDB
Protrusion Tongue MetaADEDB
Pruritus ADReCS
Psychosexual Disorder MetaADEDB
Pterygium MetaADEDB
Pulmonary Valve Incompetence MetaADEDB
Purpura ADReCS
Pyrexia ADReCS
Radicular Pain MetaADEDB
Rash ADReCS
Rash Maculo-Papular ADReCS
Rash Morbilliform ADReCS
Reaction Gastrointestinal SIDER
Red Cell Distribution Width Increased MetaADEDB
Renal Cyst MetaADEDB
Renal Impairment MetaADEDB
Reperfusion Injury MetaADEDB
Respiratory Rate Increased MetaADEDB
Retroperitoneal Haematoma MetaADEDB
Rhagades MetaADEDB
Rib Fracture MetaADEDB
Ruptured Cerebral Aneurysm MetaADEDB
Schizophrenia MetaADEDB
Schizophrenia Paranoid Type MetaADEDB
Scotoma MetaADEDB
Seizures MetaADEDB
Sensory Loss MetaADEDB
Sequestrectomy MetaADEDB
Shock ADReCS
Shock Cardiogenic MetaADEDB
Sinus Bradycardia MetaADEDB
Sinusitis MetaADEDB
Skin Disorder ADReCS
Skin Laceration MetaADEDB
Small Intestinal Obstruction MetaADEDB
Spinal Column Stenosis MetaADEDB
Spinal Disorder MetaADEDB
Staphylococcal Bacteraemia MetaADEDB
Stem Cell Transplant MetaADEDB
Stent Occlusion MetaADEDB
Stress Symptoms MetaADEDB
Stridor MetaADEDB
Superinfection Lung MetaADEDB
Supraventricular Tachycardia MetaADEDB
Surgery ADReCS
Tachycardia Ventricular MetaADEDB
Tearfulness MetaADEDB
Thrombocytopenia ADReCS
Thyroid Cancer Metastatic MetaADEDB
Tooth Extraction MetaADEDB
Tracheitis MetaADEDB
Tracheobronchitis MetaADEDB
Transaminases Increased ADReCS
Transient Ischaemic Attack MetaADEDB
Upper Gastrointestinal Bleeding MetaADEDB
Ureteritis MetaADEDB
Urticaria ADReCS
Vaginal Fistula MetaADEDB
Varicose Vein Ruptured MetaADEDB
Vascular Graft Occlusion MetaADEDB
Vascular Insufficiency MetaADEDB
Vascular Purpura ADReCS
Vasculitis ADReCS
Ventricular Dysfunction Left MetaADEDB
Ventricular Hypokinesia MetaADEDB
Viral Upper Respiratory Tract Infection MetaADEDB
Vision Blurred ADReCS
Visual Disturbance ADReCS
Visual Impairment ADReCS
Vital Functions Abnormal MetaADEDB
Vomiting ADReCS
Vulvovaginal Dryness MetaADEDB
Weakness SIDER

InAADR: Drug-Protein-ADRs database