| Drug Name: | Itraconazole (84625-61-6) |
|---|---|
| PubChem ID: | 45039617 |
| SMILES: | [2H]C([2H])([2H])C([2H])([2H])C(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl |
| InchiKey: | VHVPQPYKVGDNFY-VXTATNQMSA-N |
| Therapeutic Category: | 14-alpha Demethylase Inhibitors, Anti-Infective Agents, Antifungal Agents, Cytochrome P-450 CYP3A Inhibitors, Cytochrome P-450 Enzyme Inhibitors, Enzyme Inhibitors, Hormone Antagonists, Hormones |
| Molecular Weight (dalton) | : | 710.677 |
| LogP | : | 5.5773 |
| Ring Count | : | 5 |
| Hydrogen Bond Acceptor Count | : | 12 |
| Hydrogen Bond Donor Count | : | 0 |
| Total Polar Surface Area | : | 104.7 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Terfenadine (50679-08-8) | Torsade De Pointes | Synergistic | itraconazole reduce the metabolism of terfenadine by inhibition of the cytochrome P450 isoenzyme CYP3A | Torsades de pointes after terfenadine-itraconazole interaction |
| Vincristine (57-22-7) | Neurotoxicity | Synergistic | Not understood | Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL |
| Vincristine (57-22-7) | Paraesthesia | Synergistic | Not understood | Aggravation of vincristine-induced neurotoxicity by itraconazole in the treatment of adult ALL |
| Cabergoline (81409-90-7) | Hyperkinesia | Synergistic | Cabergoline is an ergot derivative that is metabolised by the cytochrome P450 isoenzyme CYP3A4,Itraconazole is a potent inhibitor of this isoenzyme | Cabergoline plasma concentration is increased during concomitant treatment with itraconazole |
| Rifabutin (72559-06-9) | Uveitis | Synergistic | Rifabutin increases the metabolism of itraconazole probably, at least in part, by inducing their metabolism by the cytochrome P450 CYP3A subfamily | Rifabutin prophylaxis and uveitis |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category