| Drug Name: | sulfamethoxazole (723-46-6) |
|---|---|
| PubChem ID: | 5329 |
| SMILES: | CC1=CC(=NO1)NS(=O)(=O)C2=CC=C(C=C2)N |
| InchiKey: | JLKIGFTWXXRPMT-UHFFFAOYSA-N |
| Therapeutic Category: | Anti-Infective Agents |
| Molecular Weight (dalton) | : | 253.283 |
| LogP | : | 1.36602 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 98.22 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Agranulocytosis | Albumin (P23110) | Binding to albumin increased by the presence of chloride@suggestting that N-chlorosulfamethoxazole may be one of several reactive metabolites of sulfamethoxazole that covalently bind to neutrophil@which is responsible for agranulocytosis. [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| Agranulocytosis | Myeloperoxidase precursor (P05164) | Activation of neutrophils or monocytes leads to the formation of hydrogen peroxide and the release of myeloperoxidase (MPO)@which is responsible for agranulocytosis. [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| Lupus | Albumin (P23110) | Binding to albumin increased by the presence of chloride@suggestting that N-chlorosulfamethoxazole may be one of several reactive metabolites of sulfamethoxazole that covalently bind to neutrophil@which is responsible for drug-induced lupus [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
| Lupus | Myeloperoxidase precursor (P05164) | Activation of neutrophils or monocytes leads to the formation of hydrogen peroxide and the release of myeloperoxidase (MPO)@which is responsible for drug-induced lupus. [ ADR Type 2 ] | N-chlorination of sulfamethoxazole and dapsone by the myeloperoxidase system |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category