| Drug Name: | Astemizole (68844-77-9) |
|---|---|
| PubChem ID: | 2247 |
| SMILES: | COC1=CC=C(C=C1)CCN2CCC(CC2)NC3=NC4=CC=CC=C4N3CC5=CC=C(C=C5)F |
| InchiKey: | GXDALQBWZGODGZ-UHFFFAOYSA-N |
| Therapeutic Category: |
| Molecular Weight (dalton) | : | 458.581 |
| LogP | : | 5.3513 |
| Ring Count | : | 4 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 42.32 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Ketoconazole (65277-42-1) | Torsade De Pointes | Synergistic | In vitro studies have shown that ketoconazole inhibits the metabolism of astemizole. | Combined use of astemizole and ketoconazole resulting in torsade de pointes |
| Quinine (130-95-0) | Arrhythmia | Synergistic | Uncertain | Quinine may trigger torsades de pointes during astemizole therapy |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Arrhythmias | Potassium voltage-gated channel subfamily H member 2 (Q12809) | Keynote review: in vitro safety pharmacology profiling: an essential tool for successful drug development |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category