| Drug Name: | Folic Acid (59-30-3) |
|---|---|
| PubChem ID: | 6037 |
| SMILES: | C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=O)N=C(N3)N |
| InchiKey: | OVBPIULPVIDEAO-LBPRGKRZSA-N |
| Therapeutic Category: | Growth Substances, Hematinics, Hematologic Agents, Micronutrients, Vitamin B Complex, Vitamins |
| Molecular Weight (dalton) | : | 441.404 |
| LogP | : | -0.0448 |
| Ring Count | : | 3 |
| Hydrogen Bond Acceptor Count | : | 9 |
| Hydrogen Bond Donor Count | : | 6 |
| Total Polar Surface Area | : | 213.28 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Capecitabine (154361-50-9) | Diarrhoea | Synergistic | concurrent use of folic acid enhanced capecitabine toxicity | Lethal toxicity of capecitabine due to abusive folic acid prescription? |
| Capecitabine (154361-50-9) | Hand-And-Foot Syndrome | Synergistic | concurrent use of folic acid enhanced capecitabine toxicity | Lethal toxicity of capecitabine due to abusive folic acid prescription? |
| Capecitabine (154361-50-9) | Vomiting | Synergistic | concurrent use of folic acid enhanced capecitabine toxicity | Lethal toxicity of capecitabine due to abusive folic acid prescription? |
| Fluorouracil (51-21-8) | Anorexia | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates |
| Fluorouracil (51-21-8) | Bloody Diarrhoea | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates |
| Fluorouracil (51-21-8) | Mouth Ulceration | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates |
| Fluorouracil (51-21-8) | Vaginal Bleeding | Synergistic | folic acid increases fluorouracil inhibition of thymidine formation which is important for DNA synthesis, and thereby increases fluorouracil toxicity. | Interaction of 5-fluorouracil with folates |
| Phenytoin (57-41-0) | Seizure Control Is Partially Or Totally Lost | Antagonistic | Patients taking antiepileptics may have subnormal serum folic acid levels. Frequencies of 27 to 76% have been reported for phenobarbital, primidone, and phenytoin alone or in various ombinations.8 One possible explanation is that this is due to the enzyme-inducing characteristics of these antiepileptics, which makes excessive demands on folate for the synthesis of the enzymes concerned with drug metabolism | Folic acid deficiency in patients receiving anticonvulsant drugs |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
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This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category