| Drug Name: | Pyrimethamine (58-14-0) |
|---|---|
| PubChem ID: | 4993 |
| SMILES: | CCC1=C(C(=NC(=N1)N)N)C2=CC=C(C=C2)Cl |
| InchiKey: | WKSAUQYGYAYLPV-UHFFFAOYSA-N |
| Therapeutic Category: | Anti-Infective Agents, Antimalarials, Antiparasitic Agents, Antiprotozoal Agents, Enzyme Inhibitors, Folic Acid Antagonists |
| Molecular Weight (dalton) | : | 248.717 |
| LogP | : | 2.5238 |
| Ring Count | : | 2 |
| Hydrogen Bond Acceptor Count | : | 4 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 77.82 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Sulfisoxazole (127-69-5) | Megaloblastic Anaemia | Antagonistic | Uncertain | Mechanism of pyrimethamine-induced megaloblastosis in human bone marrow |
| Zidovudine (30516-87-1) | Myelosuppression | Synergistic | Uncertain | Synergistic bone marrow toxicity of pyrimethamine and zidovudine in murine in vivo and in vitro models: mechanism of toxicity |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
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This panel provides information on drug category