InAADR

Drug Information

Drug Name: Glutamine (56-85-9)
PubChem ID: 5961
SMILES: C(CC(=O)N)[C@@H](C(=O)O)N
InchiKey: ZDXPYRJPNDTMRX-VKHMYHEASA-N
Therapeutic Category:

Computed Drug Properties

Molecular Weight (dalton): 146.146
LogP: -1.3362
Ring Count: 0
Hydrogen Bond Acceptor Count: 3
Hydrogen Bond Donor Count: 3
Total Polar Surface Area: 106.41

This panel provides information on interacting drugs and their ADRs along with references

Interacting drug Toxicity Interaction Type Mechanism Reference

This panel provides drug-protein interaction and their ADRs along with references

Toxicity Interacting Protein Mechanism Reference
Apoptosis Glucosamine--fructose-6-phosphate aminotransferase (Q06210) Increased flux through the hexosamine biosynthetic pathway with glutamine:fructose-6-phosphate-amidotransferase (GFAT) as rate-limiting enzyme has been linked to the enhanced bioactivity of the prosclerotic cytokine transforming growth factor beta1 (TGF-beta1) in fibrotic complications@ particularly in diabetic kidney disease. [ ADR Type ] Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts
Apoptosis Latent transforming growth factor beta-binding protein isoform 1L (Q14766) 1 8-fold stimulation of TGF-beta1 mRNA and a 1 9-fold increased protein expression@indicating a GFAT-dependent induction of TGF-beta1 synthesis [ ADR Type 1 ] Overexpression of glutamine:fructose-6-phosphate-amidotransferase induces transforming growth factor-beta1 synthesis in NIH-3T3 fibroblasts
Arrest Cellular Proliferation Epidermal growth factor receptor precursor (P00533) GFAT gene underGOes a late transcriptional response to EGF,which arrest cellular proliferation [ ADR Type 3 ] Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose
Arrest Cellular Proliferation Glucosamine--fructose-6-phosphate aminotransferase (Q06210) GFAT gene underGOes a late transcriptional response to EGF@which arrest cellular proliferation [ ADR Type 3 ] Regulation of glutamine:fructose-6-phosphate amidotransferase gene transcription by epidermal growth factor and glucose

This panel provides drug-food interactions and their ADRs along with references

Food Toxicity Reference

This panel provides information on metabolites and their ADRs along with references

Metabolite Toxicity Place of Metabolism Mechanism Reference

This panel provides information on drug category

Toxicity Source
Abdominal Adhesions MetaADEDB
Abdominal Discomfort MetaADEDB
Abdominal Distension ADReCS
Abdominal Pain ADReCS
Abdominal Pain MetaADEDB
Abscess Drainage MetaADEDB
Accident MetaADEDB
Accommodation Disorder MetaADEDB
Aching Joints MetaADEDB
Acidosis MetaADEDB
Activities Of Daily Living Impaired MetaADEDB
Acute Kidney Failure MetaADEDB
Adenopathy MetaADEDB
Adrenal Neoplasm MetaADEDB
Afib MetaADEDB
Allergic Reaction ADReCS
Allergic Rhinitis MetaADEDB
Allergies MetaADEDB
Alveolar Osteitis MetaADEDB
Alveolitis MetaADEDB
Amentia MetaADEDB
Anaemia MetaADEDB
Anaesthesia MetaADEDB
Anger MetaADEDB
Angiopathy ADReCS
Anhidrosis MetaADEDB
Anorectal Discomfort ADReCS
Anorexia MetaADEDB
Anxiety MetaADEDB
Apathy MetaADEDB
Arterial Pressure Nos Decreased MetaADEDB
Arthralgia ADReCS
Aspergillosis MetaADEDB
Aspiration Pneumonia MetaADEDB
Asthenia ADReCS
Atelectasis MetaADEDB
Attention Deficit/Hyperactivity Disorder MetaADEDB
Aura MetaADEDB
Autism Spectrum Disorder MetaADEDB
B-Cell Lymphoma MetaADEDB
Back Ache MetaADEDB
Back Pain ADReCS
Bacterial Disease Carrier MetaADEDB
Bacterial Infection ADReCS
Bacterial Test Positive MetaADEDB
Bacterial Toxaemia MetaADEDB
Balance Disorder MetaADEDB
Benign Pancreatic Neoplasm MetaADEDB
Bile Duct Obstruction MetaADEDB
Biliary Cirrhosis MetaADEDB
Biopsy Bone MetaADEDB
Biopsy Bone Marrow MetaADEDB
Biopsy Lymph Gland MetaADEDB
Bipolar Disorder MetaADEDB
Bladder Disorder MetaADEDB
Bladder Inflammation MetaADEDB
Bladder Retention MetaADEDB
Blindness Unilateral MetaADEDB
Blood Calcium MetaADEDB
Blood Calcium Increased MetaADEDB
Blood Cholesterol MetaADEDB
Blood In Urine MetaADEDB
Blood Sodium MetaADEDB
Blood Sodium Increased MetaADEDB
Blurred Vision MetaADEDB
Body Temperature Increased ADReCS
Bone Debridement MetaADEDB
Bone Density Decreased MetaADEDB
Bone Development Abnormal MetaADEDB
Bone Disorder MetaADEDB
Bone Fragmentation MetaADEDB
Bone Pain MetaADEDB
Bone Trimming MetaADEDB
Bradypnoea MetaADEDB
Brain Oedema MetaADEDB
Breast Pain ADReCS
Breast Pain Female ADReCS
Bronchitis MetaADEDB
Bruxism MetaADEDB
Bulging MetaADEDB
Bundle Branch Block Left MetaADEDB
Burn Oesophageal MetaADEDB
Calculus Of Kidney MetaADEDB
Candidiasis ADReCS
Capillary Leak Syndrome MetaADEDB
Carcinoma Of The Colon MetaADEDB
Cardiac Decompensation MetaADEDB
Cardiogenic Shock MetaADEDB
Cardiomyopathy MetaADEDB
Cartilage Development Disorder MetaADEDB
Catheter Placement MetaADEDB
Central Venous Catheter Removal MetaADEDB
Central Venous Catheterisation MetaADEDB
Cerebral Haemorrhage MetaADEDB
Cerebral Ischaemia MetaADEDB
Cerumen Impaction MetaADEDB
Chest Pain ADReCS
Chills ADReCS
Choking Sensation MetaADEDB
Cholangiolitis MetaADEDB
Cholecystitis MetaADEDB
Chronic Sinusitis MetaADEDB
Claustrophobia MetaADEDB
Clostridial Infection MetaADEDB
Clotting MetaADEDB
Colonoscopy MetaADEDB
Computerised Tomogram MetaADEDB
Condition Aggravated MetaADEDB
Congenital Cystic Kidney Disease MetaADEDB
Conjunctival Deposit MetaADEDB
Constipated MetaADEDB
Constipation ADReCS
Convulsion MetaADEDB
Convulsions Grand Mal MetaADEDB
Cough MetaADEDB
Cranial Nerve Disorder MetaADEDB
Crohn Disease ADReCS
Cyst MetaADEDB
Deafness Neurosensory MetaADEDB
Deglutition Disorder MetaADEDB
Dehydration ADReCS
Demyelination MetaADEDB
Dental Care MetaADEDB
Dental Fistula MetaADEDB
Depression ADReCS
Dermatitis ADReCS
Device Failure MetaADEDB
Device Related Infection MetaADEDB
Diarrhea MetaADEDB
Discomfort ADReCS
Disease Progression MetaADEDB
Disorder Lung MetaADEDB
Disorder Peripheral Vascular MetaADEDB
Dizziness ADReCS
Drowsiness MetaADEDB
Drug Toxicity MetaADEDB
Drug Withdrawal Headache MetaADEDB
Dry Mouth ADReCS
Dysgeusia MetaADEDB
Dyspnea Exertional MetaADEDB
Dysthymic Disorder MetaADEDB
Dysuria MetaADEDB
Ear Ache MetaADEDB
Ear Disorder ADReCS
Ear Infection MetaADEDB
Early Morning Awakening MetaADEDB
Eclampsia MetaADEDB
Economic Problem MetaADEDB
Eczema MetaADEDB
Emesis MetaADEDB
Emotional Disorder MetaADEDB
Endometrial Cancer MetaADEDB
Enlarged Liver MetaADEDB
Enlarged Spleen MetaADEDB
Enlargement Abdomen MetaADEDB
Enterocolitis MetaADEDB
Eruption MetaADEDB
Erythema MetaADEDB
Eustachian Tube Disorder MetaADEDB
Excessive Granulation Tissue MetaADEDB
Extrasystoles Ventricular MetaADEDB
Face Oedema ADReCS
Faecal Impaction MetaADEDB
Fat Tissue Increased MetaADEDB
Fatigue ADReCS
Fatty Liver MetaADEDB
Feeling Abnormal ADReCS
Fistula ADReCS
Flank Pain MetaADEDB
Flatulence ADReCS
Fluid Intake Reduced MetaADEDB
Formication MetaADEDB
Fungal Infection ADReCS
Fungal Sepsis MetaADEDB
Gangrene MetaADEDB
Gastric Ulcer ADReCS
Gastroenteritis MetaADEDB
Gastrointestinal Fistula ADReCS
Gastrointestinal Mucosal Exfoliation MetaADEDB
Gastrointestinal Oedema MetaADEDB
Gastrointestinal Pain ADReCS
Gingival Infection MetaADEDB
Haemorrhage Rectum MetaADEDB
Haemorrhoids ADReCS
Hair Growth Abnormal MetaADEDB
Headache ADReCS
Heart Transplant MetaADEDB
Hematoma Subdural MetaADEDB
Hepatic Function Abnormal ADReCS
High Blood Pressure MetaADEDB
Hyperbaric Oxygen Therapy MetaADEDB
Hyperhidrosis ADReCS
Hypersensitivity ADReCS
Hypertonia MetaADEDB
Hypoaesthesia MetaADEDB
Hypoaesthesia Oral MetaADEDB
Hypoalbuminaemia MetaADEDB
Hypoxia MetaADEDB
Ill-Defined Disorder ADReCS
Impaired Healing MetaADEDB
Impulse-Control Disorder MetaADEDB
Infection ADReCS
Infection Upper Respiratory MetaADEDB
Infection Urinary Tract MetaADEDB
Infertility MetaADEDB
Influenza ADReCS
Influenza Like Illness MetaADEDB
Injection Site Irritation MetaADEDB
Injection Site Pain ADReCS
Injection Site Reaction ADReCS
Insomnia ADReCS
Intention Tremor MetaADEDB
Intracardiac Thrombus MetaADEDB
Irregular Menstrual Cycle MetaADEDB
Jaw Disorder MetaADEDB
Jaw Operation MetaADEDB
Kidney Failure MetaADEDB
Knee Arthroplasty MetaADEDB
Laryngitis ADReCS
Left Ventricular Hypertrophy MetaADEDB
Leg Amputation MetaADEDB
Lethargy MetaADEDB
Leucopenia MetaADEDB
Leukopenia Neonatal MetaADEDB
Local Swelling MetaADEDB
Loose Tooth MetaADEDB
Lung Cancer Metastatic MetaADEDB
Lung Edema MetaADEDB
Lung Neoplasm MetaADEDB
Lymphadenopathy Mediastinal MetaADEDB
Lymphedema MetaADEDB
Lymphoma MetaADEDB
Macroglossia MetaADEDB
Malaise ADReCS
Malnourished MetaADEDB
Mandibular Prosthesis User MetaADEDB
Mass Excision MetaADEDB
Mediastinitis MetaADEDB
Medical Device Complication MetaADEDB
Medical Device Removal MetaADEDB
Mental Disorder MetaADEDB
Metastases To Central Nervous System MetaADEDB
Metastases To Eye MetaADEDB
Metastases To Lung MetaADEDB
Metastases To Spine MetaADEDB
Metastases To Stomach MetaADEDB
Mouth Bleeding MetaADEDB
Mucosal Erosion MetaADEDB
Multi-Organ Failure MetaADEDB
Multiple Injuries MetaADEDB
Musculoskeletal Discomfort ADReCS
Musculoskeletal Disorder MetaADEDB
Musculoskeletal Pain MetaADEDB
Myalgia ADReCS
Nail Discolouration MetaADEDB
Nail Disorder ADReCS
Nasal Congestion MetaADEDB
Nasal Mucosal Disorder MetaADEDB
Nasopharyngitis MetaADEDB
Nausea ADReCS
Near Syncope MetaADEDB
Nephrolithiasis ADReCS
Nephropathy Toxic MetaADEDB
Nephrotic Syndrome MetaADEDB
Nervous System Disorder MetaADEDB
Neumonia MetaADEDB
Neurogenic Bladder MetaADEDB
Neuropathy Peripheral ADReCS
Nodule MetaADEDB
Oedema ADReCS
Oedema Peripheral ADReCS
Oral Discomfort MetaADEDB
Oral Infection MetaADEDB
Oral Mucosa Erosion MetaADEDB
Orthopnea MetaADEDB
Osteoarthritis MetaADEDB
Osteomyelitis MetaADEDB
Osteomyelitis Chronic MetaADEDB
Oxygen Saturation Decreased MetaADEDB
Pain ADReCS
Pallor MetaADEDB
Palpitation MetaADEDB
Pancreatectomy MetaADEDB
Pancreatic Cyst MetaADEDB
Pancreatitis ADReCS
Pericardial Effusion MetaADEDB
Petechia MetaADEDB
Pharyngeal Inflammation MetaADEDB
Pharyngitis ADReCS
Pharyngoesophageal Diverticulum MetaADEDB
Pleural Effusion MetaADEDB
Pneumonia Aspergillus MetaADEDB
Pneumonia Due To Streptococcus Group B MetaADEDB
Pneumonia Streptococcal SIDER
Pollakiuria MetaADEDB
Polycystic Ovaries MetaADEDB
Post Procedural Nausea MetaADEDB
Postoperative Wound Infection MetaADEDB
Proctalgia ADReCS
Productive Cough MetaADEDB
Prosthesis Implantation MetaADEDB
Protein-Losing Gastroenteropathy MetaADEDB
Pruritus ADReCS
Psychoses MetaADEDB
Pulmonary Arrest MetaADEDB
Pulmonary Congestion MetaADEDB
Purulence MetaADEDB
Pyelonephritis ADReCS
Pyrexia ADReCS
Rash ADReCS
Rectal Tenesmus ADReCS
Reflux Esophagitis MetaADEDB
Renal Atrophy MetaADEDB
Renal Cancer MetaADEDB
Residual Urine MetaADEDB
Respiratory Disorder ADReCS
Respiratory Failure MetaADEDB
Respiratory Rate Increased MetaADEDB
Respiratory Tract Congestion MetaADEDB
Rhinitis ADReCS
Rigors MetaADEDB
Sensitivity Of Teeth MetaADEDB
Sensory Loss ADReCS
Sepsis ADReCS
Sequestrectomy MetaADEDB
Short-Bowel Syndrome MetaADEDB
Sinus Disorder MetaADEDB
Sinusitis MetaADEDB
Sinusitis Fungal MetaADEDB
Skin Disorder ADReCS
Sleep Apnea MetaADEDB
Splenectomy MetaADEDB
Subarachnoid Haemorrhage MetaADEDB
Subdural Haemorrhage MetaADEDB
Supraventricular Tachycardia MetaADEDB
Sweating MetaADEDB
Sweating Increased MetaADEDB
Temperature Intolerance MetaADEDB
Therapeutic Embolisation MetaADEDB
Thirst ADReCS
Tongue Paralysis MetaADEDB
Tooth Disease MetaADEDB
Tooth Extraction MetaADEDB
Tooth Resorption MetaADEDB
Transfusion MetaADEDB
Treatment Noncompliance MetaADEDB
Tuberculin Test Positive MetaADEDB
Tumour Lysis Syndrome MetaADEDB
Tumour Necrosis MetaADEDB
Ulcer ADReCS
Urinary Tract Disorder MetaADEDB
Uterine Cancer MetaADEDB
Vaginal Infection ADReCS
Vena Cava Injury MetaADEDB
Viral Infection ADReCS
Viral Pharyngitis MetaADEDB
Vomiting ADReCS
Wheelchair User MetaADEDB
Wheeze MetaADEDB
Wound Dehiscence MetaADEDB
Wound Infection MetaADEDB
Xerosis MetaADEDB

InAADR: Drug-Protein-ADRs database