| Drug Name: | Melphalan (148-82-3) |
|---|---|
| PubChem ID: | 460612 |
| SMILES: | C1=CC(=CC=C1C[C@@H](C(=O)O)N)N(CCCl)CCCl |
| InchiKey: | SGDBTWWWUNNDEQ-LBPRGKRZSA-N |
| Therapeutic Category: | Alkylating Agents, Antineoplastic Agents, Immunologic Factors, Immunosuppressive Agents, Myeloablative Agonists, Noxae |
| Molecular Weight (dalton) | : | 305.205 |
| LogP | : | 1.925 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 2 |
| Total Polar Surface Area | : | 66.56 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Interferon alfa (74899-72-2) | Cell-Mediated Cytotoxicity | Antagonistic | Not understood | Natural interferon-alpha in combination with melphalan/prednisone versus melphalan/prednisone in the treatment of multiple myeloma stages II and III: a randomized study from the Myeloma Group of Central Sweden |
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Expose P815 Tumor Cells To Oxidative Stress | IkappaB kinase complex-associated protein (O95163) | Exposure of P815 tumor cells to a cell-permeable peptide that selectively inhibits NF-kappaB activation by blocking the activation of the IkappaB-kinase complex was found to inhibit the L-PAM-induced B7-1 mRNA accumulation,which exposes P815 tumor cells to oxidative stress [ ADR Type 2 ] | Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells |
| Expose P815 Tumor Cells To Oxidative Stress | NF-kappaB (Q96RU7) | L-PAM leads to activation of B7-1 gene expression by activating NF-kappaB via a pathway that involves reactive oxygen species@ because NF-kappaB activation is essential for the L-PAM-induced B7-1 gene expression [ ADR Type 2 ] | Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells |
| Expose P815 Tumor Cells To Oxidative Stress | T-lymphocyte activation antigen CD80 (P33681) | Exposure of P815 tumor cells to melphalan (L-phenylalanine mustard; L-PAM) leads to up-regulation of B7-1 surface expression@which exposes P815 tumor cells to oxidative stress [ ADR Type 2 ] | Mechanism of melphalan-induced B7-1 gene expression in P815 tumor cells |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
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This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category