| Drug Name: | Atorvastatin (134523-00-5) |
|---|---|
| PubChem ID: | 60823 |
| SMILES: | CC(C)C1=C(C(=C(N1CC[C@H](C[C@H](CC(=O)O)O)O)C2=CC=C(C=C2)F)C3=CC=CC=C3)C(=O)NC4=CC=CC=C4 |
| InchiKey: | XUKUURHRXDUEBC-KAYWLYCHSA-N |
| Therapeutic Category: | Anticholesteremic Agents, Antimetabolites, Enzyme Inhibitors, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Hypolipidemic Agents, Lipid Regulating Agents |
| Molecular Weight (dalton) | : | 558.65 |
| LogP | : | 6.3136 |
| Ring Count | : | 4 |
| Hydrogen Bond Acceptor Count | : | 5 |
| Hydrogen Bond Donor Count | : | 4 |
| Total Polar Surface Area | : | 111.79 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|---|---|---|---|
| Clopidogrel (113665-84-2) | Reduce The Antiplatelet Effect Of Clopidogrel | Antagonistic | Atorvastatin is metabolised by CYP3A4 and it has been suggested that these statins may competitively inhibit the activation of clopidogrel. | Lipophilic statins interfere with the inhibitory effects of clopidogrel on platelet function — a flow cytometry study |
This panel provides drug-protein interaction and their ADRs along with references
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|---|---|
| Grapefruit Juice | Acute Renal Failure | Food–drug interaction: grapefruit juice augments drug bioavailabilityFmechanism, extent and relevance |
| Grapefruit Juice | Rhabdomyolysis | Food–drug interaction: grapefruit juice augments drug bioavailabilityFmechanism, extent and relevance |
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category