| Drug Name: | Flutamide (13311-84-7) |
|---|---|
| PubChem ID: | 3397 |
| SMILES: | CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F |
| InchiKey: | MKXKFYHWDHIYRV-UHFFFAOYSA-N |
| Therapeutic Category: | Androgen Antagonists, Antineoplastic Agents, Hormone Antagonists, Hormones |
| Molecular Weight (dalton) | : | 276.214 |
| LogP | : | 3.2081 |
| Ring Count | : | 1 |
| Hydrogen Bond Acceptor Count | : | 3 |
| Hydrogen Bond Donor Count | : | 1 |
| Total Polar Surface Area | : | 72.24 |
This panel provides information on interacting drugs and their ADRs along with references
| Interacting drug | Toxicity | Interaction Type | Mechanism | Reference |
|---|
This panel provides drug-protein interaction and their ADRs along with references
| Toxicity | Interacting Protein | Mechanism | Reference |
|---|---|---|---|
| Hepatotoxicity | CYP1A (P04798) | Flutamide is toxic to rat hepatocytes as a result of the cytochrome P450 (3A and also 1A)-mediated formation of electrophilic metabolites@ whose damaging effects are further aggravated by the inhibitory effect of flutamide on mitochondrial respiration and ATP formation | |
| Hepatotoxicity | Cytochrome P450 3A4 (P08684) | Flutamide is toxic to rat hepatocytes as a result of the cytochrome P450 (3A and also 1A)-mediated formation of electrophilic metabolites@ whose damaging effects are further aggravated by the inhibitory effect of flutamide on mitochondrial respiration and ATP formation |
This panel provides drug-food interactions and their ADRs along with references
| Food | Toxicity | Reference |
|---|
This panel provides information on metabolites and their ADRs along with references
| Metabolite | Toxicity | Place of Metabolism | Mechanism | Reference |
|---|
This panel provides information on drug category